A5060071592- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- Ion Channels and Receptors
- RNA Research and Splicing
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Plant and animal studies
- Venomous Animal Envenomation and Studies
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Antimicrobial Peptides and Activities
- Animal Behavior and Reproduction
- Animal and Plant Science Education
- Dermatology and Skin Diseases
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
Johns Hopkins University
2014-2021
Lieber Institute for Brain Development
2014-2021
Johns Hopkins Medicine
2021
Czech Academy of Sciences, Institute of Physiology
2018
Valparaiso University
2008
Itch (pruritis) and pain represent two distinct sensory modalities; yet both have evolved to alert us potentially harmful external stimuli. Compared with pain, our understanding of itch is still nascent. Here, we report a new clinical case debilitating altered perception resulting from the heterozygous de novo p.L811P gain-of-function mutation in NaV1.9, voltage-gated sodium (NaV) channel subtype that relays information periphery spine. To investigate role NaV1.9 itch, developed mouse line...
Here, we report the discovery of a novel anticonvulsant drug with molecular organization based on unique scaffold rufinamide, an anti-epileptic compound used in clinical setting to treat severe epilepsy disorders such as Lennox-Gastaut syndrome. Although accumulating evidence supports working mechanism through voltage-gated sodium (Nav) channels, found that clinically relevant rufinamide concentration inhibits human (h)Nav1.1 activation, distinct among anticonvulsants and feature worth...
Significance In this study, we report the identification of first potent GABA A receptor-targeting toxins, to our knowledge, in snake venom, which provides a conceptual example for discovering novel ligands study receptor family, both functionally and structurally. Moreover, successful synthetic recombinant production these toxins [micrurotoxin1 (MmTX1) MmTX2] will be valuable further enhance their subtype selectivity or potency. broader context, may provide tools evoke seizures assays...
Better understanding of the progression neural stem cells (NSCs) in developing cerebral cortex is important for modeling neurogenesis and defining pathogenesis neuropsychiatric disorders. Here, we use RNA sequencing, cell imaging, lineage tracing mouse human vitro NSCs monkey brain sections to model generation cortical neuronal fates. We show that conserved signaling mechanisms regulate acute transition from proliferative committed glutamatergic excitatory neurons. As telencephalic develop...
SUMMARY Better understanding the progression of neural stem cells (NSCs) in developing cerebral cortex is important for modeling neurogenesis and defining pathogenesis neuropsychiatric disorders. Here we used RNA-sequencing, cell imaging lineage tracing mouse human vitro NSCs to model generation cortical neuronal fates. We show that conserved signaling mechanisms regulate acute transition from proliferative committed glutamatergic excitatory neurons. As telencephalic developed pluripotency ,...