A5101498244- Sirtuins and Resveratrol in Medicine
- Cancer-related Molecular Pathways
- Healthcare and Venom Research
- Cell death mechanisms and regulation
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- RNA Research and Splicing
- Plant Pathogens and Fungal Diseases
- Ferroptosis and cancer prognosis
- Plant Parasitism and Resistance
- Drug Transport and Resistance Mechanisms
- Horticultural and Viticultural Research
- Virus-based gene therapy research
- Glutathione Transferases and Polymorphisms
- Neurogenetic and Muscular Disorders Research
- Kruppel-like factors research
- Silymarin and Mushroom Poisoning
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Streptococcal Infections and Treatments
- Persona Design and Applications
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
Jiangxi Provincial Children's Hospital
2023
First Affiliated Hospital of Jiangxi Medical College
2023
Nanchang University
2012-2023
First Affiliated Hospital of Jinan University
2021-2023
Nanjing Agricultural University
2020
Nanjing University of Chinese Medicine
2017
Abstract Metformin (Met) exhibits anticancer ability in various cancer cell lines. This report aims to explore the exact molecular mechanism of Met-induced apoptosis HCT116 cells, a human colorectal line. reactive oxygen species (ROS) increase and ROS-dependent death accompanied by plasma membrane blistering, mitochondrial swelling, loss potential, release cytochrome c. Western blotting analysis showed that Met upregulated Bak expression but downregulated Bax expression. Most importantly,...
Clinically, neuropathic pain is a severe side effect of oxaliplatin chemotherapy, which usually leads to dose reduction or cessation treatment. Due the unawareness detailed mechanisms oxaliplatin-induced pain, it difficult develop an effective therapy and limits its clinical use.The aim present study was identify role sirtuin 1 (SIRT1) in epigenetic regulation expression voltage-gated sodium channels 1.7 (Nav1.7) dorsal root ganglion (DRG) during pain.Controlled animal study.University...
Background. Early diagnosis of pediatric sepsis is difficult, so it necessary to find a reliable auxiliary diagnostic method. The purpose the study was assess role RDW in sepsis. Methods. We did case control reviewing inpatients (≥28 days, < 18 years old) who were diagnosed with between April 2020 and November 2022. According sepsis-3 Pediatric Sequential Organ Failure Assessment (pSOFA) scoring standards, 66 septic intensive care unit (PICU) included group non-septic PICU...
To analyze variants of SMN gene in a Chinese pedigree affected with Spinal muscular atrophy (SMA).A diagnosed at the Nanchang First Hospital January 2020 was selected as study subject. Peripheral blood samples were collected for extraction DNA. All exons detected by multiple ligation-dependent probe amplification (MLPA). Potential also Whole exome sequencing (WES), and result verified Sanger sequencing. cDNA extracted from fresh sample used template to verify location variant on genes.The...