A5020541738- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Medicinal Plants and Neuroprotection
- Prenatal Screening and Diagnostics
- Fish Ecology and Management Studies
- Autism Spectrum Disorder Research
- Cholinesterase and Neurodegenerative Diseases
- Telomeres, Telomerase, and Senescence
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Infant Nutrition and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- Forensic and Genetic Research
- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
Bulgarian Academy of Sciences
2009-2024
Institute of Plant Physiology and Genetics
2020-2024
The potential of Marrubium vulgare to alleviate scopolamine (Sco)-induced deficits in spatial working memory has drawn considerable scientific interest. This effect is partly attributed its potent antioxidant and acetylcholinesterase inhibitory (AChEI) activities. study examined the effects M. extract, standardized marrubiin content, on recognition healthy Sco-treated rats. Male Wistar rats (200–250 g) were divided into four groups. extract was orally administered for 21 days Sco (2 mg/kg)...
Alzheimer's disease (AD) is a complex neurodegenerative with multifactorial etiology, unsatisfactory treatment, and necessity for broad-spectrum active substances cure. The mucus from Helix aspersa snail mixture of bioactive molecules antimicrobial, anti-inflammatory, antioxidant, anti-apoptotic effects. So far there are no data concerning the capacity extract (SE) to affect disorders.The effects SE on learning memory deficits in type dementia (ATD) induced by scopolamine (Sco) male Wistar...
Abstract Background and objectives. Though numerous studies have shown that the dysregulation of epigenetic control is involved in disease manifestation, limited data available on transcriptional activity DNA methylation related genes alcohol drug addiction. With regard to this, this study we analyzed expression levels methylation, including DNMT1, DNMT3a, MeCP2, MBD1, MBD2, MBD3 MBD4, blood samples dependent persons comparison healthy abstainers. Methods. The included 51 participants: 16...
FMR1 gene (fragile X mental retardation 1) represents a genetic and epigenetic factor in number of human diseases. Though the role substance use disorders (SUDs) is not well studied, investigations indicate that SUDs FMR1-accociated may share common underlying mechanisms. We examined relative mRNA levels their sex-distribution leukocytes from patients with alcohol drug dependence compared to healthy controls. The study included 44 participants, 16 (mean age 43, 10 males 6 females), 17 41, 12...
The effect of transforming growth factor α (TGFα) on the expression imprinted genes Igf2, H19 and Pegl/Mest in diploid parthenogenetic mouse embryos (PE) from hybrids (CBA x C57BL/6)F1 posimplantational period embryonal development has been studied. PE were treated with TGFα vitro at morula stage after to blastocyst transplanted uterus pseudopregnant females. At day 10 begining pregnancy explanted for culturing 48 hours. Peg1/Mest was studied by methods RT-PCR u whole mount situ RNA-RNA...
Abstract Background and objectives. Though glyceraldehyde-3-phosphate dehydrogenase (Gapdh) is one of the most commonly used housekeeping genes for comparison gene expression data, studies have revealed that Gapdh not constant at different developmental stages, modulated by many factors including ethanol. In view this, in present study, we investigated effect ethanol on stability levels model systems. Methods. Evaluation was determined with three alcohol-exposed control mouse blastocysts,...