A5081175430- Radiopharmaceutical Chemistry and Applications
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- Telomeres, Telomerase, and Senescence
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- vaccines and immunoinformatics approaches
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
- Chemical Synthesis and Analysis
- Neuroendocrine Tumor Research Advances
- Advanced Biosensing Techniques and Applications
- SARS-CoV-2 detection and testing
- Circular RNAs in diseases
- Antimicrobial Peptides and Activities
- Polyomavirus and related diseases
- Cancer Research and Treatments
- Ferrocene Chemistry and Applications
- Muscle Physiology and Disorders
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2016-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Inbios (Italy)
2011-2012
University of Naples Federico II
2007-2009
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi
2007
Abstract Background Early diagnosis of hepatocellular carcinoma (HCC) is essential towards the improvement prognosis and patient survival. Circulating markers such as α-fetoprotein (AFP) micro-RNAs represent useful tools but still have limitations. Identifying new can be fundamental to improve both prognosis. In this approach, we harness potential metabolomics lipidomics uncover signatures HCC. Methods A combined untargeted plasma profiling 102 HCV-positive patients was performed by HILIC...
Inflammation of intestinal tissue in patients affected by celiac disease (CD) originates from the adaptive and innate immune responses elicited undigested gliadin fragments through molecular mechanisms not yet completely described. Undigested A-gliadin peptide P31-43 is central to CD pathogenesis, entering enterocytes vesicular compartments endocytosis inducing an response mucosa. This study focused on reasons why does behave as immunogenic agent. Once obtained NMR analysis,...
Formylation of amino groups is a critical reaction involved in several biological processes including post-translational modification histones. The addition formyl group (CHO) to the N-terminal end peptide chain generates biologically active molecules. N-formyl-peptides can be produced by different methods. We performed N-formylation two chemotactic hexapetides, Met1-Leu2-Lys3-Leu4-Ile5-Val6 and Met1-Met2-Tyr3-Ala4-Leu5-Phe6, carrying out directly on peptidyl-resin following pre-activation...
Abstract The development of suitable radioligands for targeting CCK‐2 receptor expressing tumors, such as medullary thyroid carcinoma, is great clinical interest. In the search best CCK‐2R binding peptides, we have synthesized, evaluated and compared CCK8 peptide (Asp‐Tyr‐Met‐Gly‐Trp‐Met‐Asp‐PheNH 2 ) two gastrin analogs commonly referred to MG0 ( D Glu‐Glu(5)‐Ala‐Tyr‐Gly‐Trp‐Met‐Asp‐PheNH MG11 Glu(1)‐Ala‐Tyr‐Gly‐Trp‐Met‐Asp‐PheNH ). N‐terminal portion three sequences was derivatized by...
Abstract The radiolabeling of the natural octapeptide CCK8, derivatized with a cysteine residue (Cys‐Gly‐CCK8), by using metal fragment [ 99m Tc(N)(PNP3)] 2+ (PNP3 = N , ‐bis(dimethoxypropylphosphinoethyl)methoxyethylamine) is reported. Tc(N)(NS‐Cys‐Gly‐CCK8)(PNP3)] + complex was obtained according to two methods (one‐step or two‐step procedure) that gave desired compound in high yield. stable aqueous solution and phosphate buffer. In vitro challenge experiments an excess glutathione...
Abstract Background The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has unpredictable manifestations of disease (COVID-19) and variable clinical course some patients being asymptomatic whereas others experiencing distress, or even death. We aimed to evaluate the immunoglobulin G (IgG) response towards linear peptides on a peptide array containing sequences from SARS-CoV-2, Middle East syndrome-related (MERS) common-cold coronaviruses 229E, OC43, NL63 HKU1...
Both SARS-CoV-2 mRNA-based vaccines [BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)] have shown high efficacy, with very modest side effects in limiting transmission of preventing the severe COVID-19 disease, characterized by a worrying occupation intensive care units (ICU), frequency intubation ultimately mortality rate. At INT, Naples, only BNT162b2/Pfizer vaccine has been administered to cancer patients healthcare professionals aged 16 over. In present study, antibody response levels...
The leader peptide of a recombinant manganese superoxide dismutase (rMnSOD-Lp) acts as molecular carrier. Clonogenic tests on normal (MRC-5) and endometrial adenocarcinoma cells (HTB-112) were carried out in the presence rMnSOD-Lp, cisplatin alone (CC) or conjugated to rMnSOD-Lp (rMnSOD-Lp-CC). platinum delivered into was measured by atomic spectrophotometric absorbance. treatments tumor finally evaluated LM TM microscopy. Tumor cell death case 0.5 μM its own minimal, while rMnSOD-Lp-CC, no...
Human oncoviruses are able to subvert telomerase function in cancer cells through multiple strategies. The activity of the catalytic subunit (TERT) is commonly enhanced virus-related cancers. Viral oncoproteins, such as high-risk human papillomavirus (HPV) E6, Epstein-Barr virus (EBV) LMP1, Kaposi sarcoma-associated herpesvirus (HHV-8) LANA, hepatitis B (HBV) HBVx, C (HCV) core protein and T-cell leukemia virus-1 (HTLV-1) tax protein, interact with regulatory elements infected contribute...