A5069088998- Down syndrome and intellectual disability research
- Functional Brain Connectivity Studies
- Education Systems and Policy
- Forest Insect Ecology and Management
- Fire effects on ecosystems
- Immunodeficiency and Autoimmune Disorders
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant and fungal interactions
- Schizophrenia research and treatment
- Entomological Studies and Ecology
- Teacher Education and Leadership Studies
- Diabetes Management and Research
- Neural and Behavioral Psychology Studies
- Library Science and Administration
- Medical Coding and Health Information
- Media, Gender, and Advertising
- Advanced Combinatorial Mathematics
- Attention Deficit Hyperactivity Disorder
- COVID-19 and Mental Health
- Hepatitis B Virus Studies
- Finite Group Theory Research
- Seedling growth and survival studies
- Teaching and Learning Programming
Colorado State University
2023-2024
Duke Medical Center
2013-2023
University of Alberta
2022
Diabetes Canada
2022
Duke University Hospital
2005-2021
Birkbeck, University of London
2021
University of Wisconsin–Madison
2020
University of Hartford
2019
University of Auckland
2019
RTC North (United Kingdom)
2018
Abstract Research to guide clinicians in the management of devastating regression which can affect adolescents and young adults with Down syndrome is limited. A multi‐site, international, longitudinal cohort individuals a clinical diagnosis Unexplained Regression (URDS) was collated through seven clinics. Tiered medical evaluation, 28‐item core symptom list, interim are described naturalistically. Improvement—defined by percentage baseline function on Parent‐reported Functional Score,...
Turner syndrome is a genetic disorder that results from an abnormal or missing X chromosome in females and typically associated with impairments visuospatial, but not verbal, information processing. These visuospatial processing may be exacerbated increased task demands, such as those engaged during working memory (WM). While previous studies have examined spatial WM function syndrome, none directly compared the neural correlates of verbal processes across encoding, maintenance retrieval...
Down syndrome disintegrative disorder ( DSDD ) is an increasingly identified condition characterized by cognitive decline, autistic characteristics, insomnia, catatonia, and psychosis in adolescents young adults with syndrome. Previously we reported a higher rate of autoimmune thyroid disease these patients compared unaffected individuals We therefore hypothesized may some cases be immune‐mediated. Here report four treated immunotherapy. Families were interviewed retrospectively for symptoms...
With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer's disease (AD). The LIFE-DSR study (NCT04149197) longitudinal natural history recruiting 270 adults DS over age 25. designed to characterize trajectories change in DS-associated AD (DS-AD). current reports its cross-sectional analysis first 90 subjects enrolled. Plasma biomarkers phosphorylated tau protein (p-tau), neurofilament light...
The pathogenesis of delayed-onset tissue nodules (DTNs) due to hyaluronic acid (HA) injections is uncertain.To formulate a rational theory for DTN development and their avoidance treatment.A multidisciplinary multicountry consensus panel was established, with 20 questions posed sought. Consensus set at 75% agreement.Consensus reached in 16 regarding the DTNs, forming basis classification treatment guide.The group believes that filler, pathogens, inflammation are all involved DTNs most likely...
Individuals with Down syndrome (DS) are at increased risk for being overweight/obese, but the associated cardiometabolic (CR) is not clear. Cross-sectional anthropometric and clinical laboratory data from a multi-site, international cohort of individuals DS were analyzed to determine by reporting observed distributions biomarkers in overweight/obese throughout lifespan. Descriptive statistics regression analyses age categories determined distributive percentiles tested adiposity as predictor...
Individuals with Down syndrome (DS) have decreased cholinergic function and an uneven profile of cognitive abilities, more pronounced deficits in learning, memory, expressive language. Cholinesterase inhibitors may improve adults adolescents DS, but studies children DS been limited. This study aimed to: (i) investigate the safety efficacy rivastigmine treatment; (ii) build upon our open‐label a double‐blind, placebo‐controlled clinical trial; (iii) specific domains that respond to treatment....
Down syndrome disintegrative disorder (DSDD) is a condition of unknown etiology characterized by acute cognitive decline, catatonia, insomnia, and autistic features in individuals with syndrome. A prior report four patients DSDD suggested potential autoimmune based on the presence autoantibodies successful treatment immunotherapy that included intravenous immunoglobulin (IVIG). Herein, we present case an 8-year old girl who developed decline to dementia-like state, features. In contrast...
Although emotionally salient stimuli influence higher order information processing, the relative vulnerability of specific stages cognitive processing to modulation by emotional input remains elusive. To test temporal dynamics interference during executive function, we recorded event-related potentials (ERPs) while participants performed an effortful anticipation task with aversive and neutral distracters. Participants were presented a modified delayed Stroop that dissociated easier or more...
Abstract In the western United States, mountain pine beetles (MPBs) have caused tree mortality across 7% of forested area over past three decades, leading to concerns increased fire activity in MPB-affected landscapes. While behavior modeling suggests MPB-associated changes fuels may influence behavior, retrospective studies generally found negligible or weak effects pre-fire MPB outbreak on activity. This apparent disagreement arise from differences weather, fuels, scale and highlights need...
Abstract Objective Eating disorders develop as a result of genetic and environmental factors. Given that they are multifactorial conditions with component, fall within the scope practice for counseling, but people these rarely referred. The purpose this study was to explore perceptions causes eating disorders, recurrence risk, interest in counseling testing among individuals disorders. Method An online survey comprising both multiple choice free form text questions, vignettes about ED100K...
Reforestation activities such as tree planting are an important tool to offset carbon emissions, restore forest ecosystem integrity, and maintain essential services. Major financial investments recent policy changes expected accelerate rates of throughout burned landscapes in the United States (US), but impacts have not been broadly examined. We quantified outcomes (1987-2022) post-fire plantings western US using remotely sensed estimates cover change in-situ survival records (69,745...
Individuals with 22q11.2 deletion syndrome (22q11.2DS) have an increased chance of developing a psychiatric disorder. While parents children affected by 22q11.2DS typically receive counseling about risk for non-psychiatric health concerns, genetic counselors may be reluctant to discuss risk. Further education necessary encourage discussion these families. The goal this project was develop recommendations provide information families 22q11.2DS. were developed synthesizing resources in the...