A5000433793- Hedgehog Signaling Pathway Studies
- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Cellular transport and secretion
- Plant Reproductive Biology
- DNA Repair Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Animal Behavior and Reproduction
- Plant and animal studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant and Biological Electrophysiology Studies
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- RNA Interference and Gene Delivery
- Congenital Ear and Nasal Anomalies
- Genetics and Neurodevelopmental Disorders
- Insect and Pesticide Research
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
Centro de Biología Molecular Severo Ochoa
2012-2025
Universidad Autónoma de Madrid
2012-2025
Consejo Superior de Investigaciones Científicas
2011-2025
University of Exeter
2014-2016
Instituto Cajal
2004-2011
Universidad de Guadalajara
2004-2011
During Drosophila epithelial development, dynamic signalling filopodia (cytonemes) establish direct contacts between distant cells to facilitate the formation of Hedgehog gradient. However, not much is known about how cytonemes are regulated. In this study, we show that cytoneme dynamics and in epithelia depend on Epidermal Growth Factor pathway its downstream effector Ras1. We describe EGFR/Ras1 required maintain wing disc epithelium basal plasma membrane levels Interference (Ihog), a...
The extent of female multiple mating (polyandry) can strongly impact on the intensity sexual selection, conflict, and evolution cooperation sociality. More subtly, polyandry may protect populations against intragenomic conflicts that result from invasion deleterious selfish genetic elements (SGEs). SGEs commonly impair sperm production, so are likely to be unsuccessful in competition, potentially reducing their transmission polyandrous populations. Here, we test this prediction nature. We...
Drosophila telomeres are sequence-independent structures maintained by transposition to chromosome ends of three specialized retroelements rather than telomerase activity. Fly protected the terminin complex that includes HOAP, HipHop, Moi and Ver proteins. These fast evolving, non-conserved proteins localize function exclusively at telomeres, protecting them from fusion events. We have previously suggested is functional analogue shelterin, multi-protein protects human telomeres. Here, we use...
Abstract The steroid hormone 20-hydroxyecdysone (20E) regulates gene transcription through the heterodimeric nuclear receptor composed of ecdysone (EcR) and Ultraspiracle (USP). EcR encodes three protein isoforms—A, B1, B2—with variant N-terminal domains that mediate tissue developmental stage-specific responses to 20E. Ariadne-1a is a conserved member RING finger family ubiquitin ligases first identified in Drosophila melanogaster. Loss-of-function mutations at key cysteines either two...