A5045433952- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Cancer Genomics and Diagnostics
- Selenium in Biological Systems
- Medical and Biological Ozone Research
- Nicotinic Acetylcholine Receptors Study
- Systemic Lupus Erythematosus Research
- Colorectal and Anal Carcinomas
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
- Cerebrovascular and genetic disorders
- Anesthesia and Neurotoxicity Research
- Genetic factors in colorectal cancer
- interferon and immune responses
- Cardiac Ischemia and Reperfusion
- Advanced Nanomaterials in Catalysis
- Acute Ischemic Stroke Management
University of Manchester
2020-2025
Manchester Academic Health Science Centre
2022-2024
National Health Service
2023
St Mary's Hospital
2020
Lynch syndrome (LS) predisposes to endometrial cancer (EC), colorectal cancer, and other cancers through inherited pathogenic variants affecting mismatch-repair (MMR) genes. Diagnosing LS in women with EC can reduce subsequent mortality colonoscopic surveillance aspirin chemoprevention; it also enables cascade testing of relatives. A growing consensus supports screening EC; however, the expected proportion test positives, optimal strategy is uncertain. Previous studies from insurance-based...
Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID the second most prevalent cause of elderly, after Alzheimer's disease (AD), with frequent cooccurrence AD. While multiple factors are involved pathogenesis AD VCID, APOE4 increases risk for both diseases. A major apolipoprotein E (apoE) receptor, low-density lipoprotein receptor-related protein 1 (LRP1), abundantly expressed...
The deficit in cerebral blood flow (CBF) seen patients with hypertension-induced vascular dementia is increasingly viewed as a therapeutic target for disease-modifying therapy. Progress limited, however, due to uncertainty surrounding the mechanisms through which elevated pressure reduces CBF. To investigate this, we used BPH/2 mouse, polygenic model of hypertension. At 8 mo age, hypertensive mice exhibited reduced CBF and cognitive impairment, mimicking human presentation dementia. Small...
ABSTRACT Background SARS‐CoV2 infections increase the risk of ischemic stroke (IS), potentially through a thromboinflammatory cascade driven by an imbalance in ratio Von Willebrand Factor (VWF) and disintegrin metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13), leading to formation ultra‐large VWF (UL‐VWF). However, infection's contribution any VWF/ADAMTS13 axis subsequent response post‐stroke remain poorly understood. Methods We performed detailed profile plasma...
Aicardi-Goutières syndrome (AGS1-9) is a genetically determined encephalopathy that falls under the type I interferonopathy disease class, characterized by excessive interferon (IFN-I) activity, coupled with upregulation of IFN-stimulated genes (ISGs), which can be explained vital role these proteins play in self-non-self-discrimination. To date, few mouse models fully replicate vast clinical phenotypes observed AGS patients. Therefore, we investigated use zebrafish as an alternative species...