Laurel Marsh

ORCID: 0000-0003-0994-2646
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About
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Research Areas
  • Intracranial Aneurysms: Treatment and Complications
  • Vascular Malformations Diagnosis and Treatment
  • Cerebrovascular and Carotid Artery Diseases
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Cardiovascular Health and Disease Prevention
  • Aortic aneurysm repair treatments
  • Bone fractures and treatments
  • Advanced MRI Techniques and Applications
  • Aerospace Engineering and Energy Systems
  • Biomimetic flight and propulsion mechanisms
  • Acute Ischemic Stroke Management
  • Advanced Aircraft Design and Technologies
  • Angiogenesis and VEGF in Cancer
  • Knee injuries and reconstruction techniques
  • Aerospace and Aviation Technology
  • Robotic Path Planning Algorithms
  • Spinal Hematomas and Complications
  • Case Reports on Hematomas
  • Total Knee Arthroplasty Outcomes
  • Aerospace Engineering and Control Systems
  • Cerebrospinal fluid and hydrocephalus
  • Artificial Intelligence in Healthcare and Education
  • Cardiovascular Function and Risk Factors
  • Reconstructive Surgery and Microvascular Techniques

George Mason University
2024-2025

University of Tulsa
2025

University of Oklahoma
2025

University Hospital Magdeburg
2022-2024

University of Washington
2019-2023

Seattle University
2023

Cheltenham General Hospital
2007

To determine the top 100 cited authors and 20 articles in Journal of Orthopaedic Trauma (JOT) compare its impact factor to orthopaedic non-orthopaedic surgery literature. Review. The Web Science database was used that originated JOT from 1995 present. total number citations for each article author first, last, any position publications JOT, location training current place work were gathered. Each author's as first tallied authors. Citation Reports searched (IF) multiple journals 1997 2023....

10.1097/bot.0000000000002964 article EN Journal of Orthopaedic Trauma 2025-01-29

BACKGROUND The utilizationof patches in carotid endarterectomy (CEA) for artery stenosis remains controversial, with conflicting evidence regarding postoperative outcomes. This report accentuates this discourse two selected representative cases divergent OBSERVATIONS Computational fluid dynamics analyses of pre- and post-CEA hemodynamics revealed distinct hemodynamic profiles between the patients. In nonpatched internal (ICA), vessel retained a cylindrical shape, exhibiting swirling blood...

10.3171/case24840 article EN Journal of Neurosurgery Case Lessons 2025-04-07

ABSTRACT Currently, it is unclear why some patients experience restenosis after carotid endarterectomy (CEA) and whether the closing procedure linked to greater rates of restenosis. Here, morphology hemodynamics are compared for bulb two post‐CEA. One was closed with a patch which later suffered restenosis, while other patient's treated using primary closure did not. Contrast‐enhanced magnetic resonance angiography (CE‐MRA) segmented provide domain computational fluid dynamics (CFD)....

10.1002/cnm.70048 article EN cc-by-nc International Journal for Numerical Methods in Biomedical Engineering 2025-05-01

Abstract Background Computational fluid dynamics (CFD) simulations are a powerful tool for studying cerebral aneurysms, capable of evaluating hemodynamics in way that is infeasible with imaging alone. However, the difficulty incorporating patient‐specific information and inherent obstacles vivo validation have limited clinical usefulness CFD aneurysms. In this work we investigate effect using standardized blood viscosity values aneurysms when compared to same derived from hematocrit...

10.1002/mp.16926 article EN Medical Physics 2023-12-27

Minimally-invasive therapies are well-established treatment methods for saccular intracranial aneurysms (SIAs). Knowledge concerning fusiform IAs (FIAs) is low, due to their wide and alternating lumen infrequent occurrence. However, FIAs carry risks like ischemia thus require further in-depth investigation. Six patient-specific IAs, comprising three position-identical SIAs, with the showing a non-typical FIA shape, were compared, respectively. For each model, healthy counterpart treated...

10.3390/jcm13020551 article EN Journal of Clinical Medicine 2024-01-18

Due to their effect on aneurysm hemodynamics, flow diverters (FD) have become a routine endovascular therapy for intracranial aneurysms. Since over- and undersizing affect the device’s hemodynamic abilities, selecting correct device diameter accurately simulating FD placement can improve patient-specific outcomes. The purpose of this study was validate accuracy virtual diverter deployments in novel Derivo® 2 device. We retrospectively analyzed blood flows ten placements which 3D DSA datasets...

10.3390/fluids9030055 article EN cc-by Fluids 2024-02-23

ABSTRACT The mechanisms leading to aneurysm occlusion after treatment with flow‐diverting devices are not fully understood. Flow modification induces thrombus formation within the cavity, but fibrin can simultaneously accumulate and cover device scaffold, further flow modification. However, interplay relative importance of these processes clearly A computational model accumulation diversion cerebral aneurysms has been developed under guidance in vitro experiments observations. is based on...

10.1002/cnm.3883 article EN cc-by International Journal for Numerical Methods in Biomedical Engineering 2024-11-05

As frequency of endovascular treatments for intracranial aneurysms increases, there is a growing need to understand the mechanisms coil embolization failure. Computational fluid dynamics (CFD) modeling often simplifies coils as homogeneous porous medium (PM), and focuses on vascular wall endothelium, not considering biomechanical environment platelets. These assumptions limit accuracy computations treatment predictions. We present rigorous analysis using X-ray microtomographic imaging...

10.1115/1.4050375 article EN Journal of Biomechanical Engineering 2021-03-05

Numerous studies assess intracranial aneurysm rupture risk based on morphological and hemodynamic parameter analysis in addition to clinical information such as localization, age, sex. However, aneurysms mostly occur with a saccular shape located either lateral the parent artery or at bifurcation. In contrast, fusiform (FIAs), i.e., non-saccular, dilated form, approximately 3–13% of all cases therefore have not yet been thoroughly studied. To improve understanding FIA hemodynamics, this...

10.3389/fneur.2021.771694 article EN cc-by Frontiers in Neurology 2022-01-24

Abstract Hemodynamic factors have long been associated with clinical outcomes in the treatment of cerebral aneurysms. Computational studies aneurysm hemodynamics provided valuable estimates mechanical environment experienced by endothelium both parent vessel and aneurysmal dome walls correlated them disease state. These computational-clinical recently response endothelial cells (EC) using either idealized or patient-specific models. Here, we present a robust workflow for generating...

10.1115/1.4054981 article EN Journal of Biomechanical Engineering 2022-07-15

Successful occlusion of cerebral aneurysms using coil embolization is contingent upon stable thrombus formation, and the quality depends biomechanical environment. The goal this study was to investigate how alters mechanical micro-environment within aneurysm dome. Inertialess particles were injected in three-dimensional, computational simulations flow inside patient patient-specific boundary conditions. Coil simulated as a homogenous porous medium known permeability inertial constant....

10.1115/1.4055857 article EN Journal of Biomechanical Engineering 2022-10-04

10.1080/01443610701359951 article EN Journal of Obstetrics and Gynaecology 2007-01-01

As the number of cerebral aneurysms treated with flow diverters continues to increase, it is important understand what factors influence not only thrombus formation within aneurysm cavity but also fibrin accumulation across device and its associated disruption blockage inflow stream. Both processes contribute eventual occlusion or continued patency incomplete which may require future re-treatment. To investigate on placed neck aneurysms, a previously developed computational model that...

10.1002/cnm.3904 article EN cc-by-nc-nd International Journal for Numerical Methods in Biomedical Engineering 2024-12-26

Abstract This paper studies the effect of rotor blade aerodynamics and grouping on accuracy open-loop simulations with respect to generated trajectories energy consumption for multi-rotor drones. To examine these effects an 18-rotor high performance drone carrying a 30 kg payload is used. The aerodynamic model simulation results examined by comparing roll, pitch, yaw, vertical motion produced when using element theory lumped model. show 20% difference between maximum roll pitch angle...

10.1115/detc2020-22481 article EN 2020-08-17

ABSTRACT Cerebral aneurysms are a serious clinical challenge, with ∼half resulting in death or disability. Treatment via endovascular coiling significantly reduces the chances of rupture, but technique has failure rates between 25-40%. This presents pressing need to develop method for determining optimal coil deployment strategies. Quantification aneurysm hemodynamics through computational fluid dynamics (CFD) potential improve understanding mechanics and treatment outcomes, accurately...

10.1101/2023.02.27.23286512 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2023-03-01

<h3>Background</h3> Aneurysm coil packing density has been studied as a surrogate for treatment outcome, but clinical results are conflicting. Previous work applying computational fluid dynamics simulations to embolization of cerebral aneurysms found that increases residence time (RT) and lowers cumulative shear (shear history; SH) blood components within the aneurysm dome, suggesting promotes clot formation via low stress-mediated pathway associated with stagnation flow.<sup>1</sup> The...

10.1136/jnis-2023-snis.71 article EN 2023-07-01

<h3>Background</h3> Successful treatment of cerebral aneurysms with flow diverting stents (FDS) depends upon altering biomechanical forces to precipitate stable thrombus formation. Computational fluid dynamics (CFD) simulations can model such for outcome prediction, and particle tracking methods simulate the behavior components blood as platelets. Previous work using a porous medium (PM) stent surface demonstrated changes in metrics following treatment.(1) However, fidelity PM representation...

10.1136/jnis-2023-snis.88 article EN 2023-07-01
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