A5017246180- Advanced Fiber Laser Technologies
- Laser-Matter Interactions and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Fluorescence Microscopy Techniques
- Photonic Crystal and Fiber Optics
- Photoreceptor and optogenetics research
- Spectroscopy and Laser Applications
- Spectroscopy and Quantum Chemical Studies
- Neuroscience and Neural Engineering
- Optical Coherence Tomography Applications
- Spectroscopy and Chemometric Analyses
- Terahertz technology and applications
- Nonlinear Optical Materials Studies
- Laser-Plasma Interactions and Diagnostics
- Photonic and Optical Devices
- Receptor Mechanisms and Signaling
- Solid State Laser Technologies
- Photoacoustic and Ultrasonic Imaging
- Advanced Fiber Optic Sensors
- Quantum optics and atomic interactions
- Ion Channels and Receptors
- Porphyrin and Phthalocyanine Chemistry
- Circadian rhythm and melatonin
- Semiconductor Lasers and Optical Devices
- Laser-induced spectroscopy and plasma
Lomonosov Moscow State University
2016-2025
Center for Theoretical Problems of Physicochemical Pharmacology
2025
Russian Quantum Center
2015-2024
Moscow State University
2023-2024
Institute of Bioorganic Chemistry
2024
Kazan State Technical University named after A. N. Tupolev
2018-2021
International University in Moscow
2013
Kurchatov Institute
2013
Texas A&M University
2013
Institute of Normal Physiology named after P.K. Anokhin
2013
High-harmonic generation (HHG) has recently been extended to solids, enabling all-optical reconstruction of electron band structure. However, material absorption above-the-bandgap interband harmonics used for this purpose in earlier work limits the applicability promising technique. Here, sub-100-fs mid-infrared pulses tunable within range wavelengths from 5.0 6.7 μm are study HHG ZnSe. Below-the-bandgap high-order generated by such driver fall transparency a solid material, thus removing...
When coupled to characteristic, fingerprint vibrational and rotational motions of molecules, an electromagnetic field with appropriate frequency waveform offers a highly sensitive, informative probe, enabling chemically specific studies on broad class systems in physics, chemistry, biology, geosciences medicine. The frequencies these signature molecular modes, however, lie region where accurate spectroscopic measurements are extremely difficult because the lack efficient detectors...
Abstract Thermogenetics is a promising innovative neurostimulation technique, which enables robust activation of neurons using thermosensitive transient receptor potential (TRP) cation channels. Broader application this approach in neuroscience is, however, hindered by limited variety suitable ion channels, and low spatial temporal resolution neuronal when TRP channels are activated ambient temperature variations or chemical agonists. Here, we demonstrate rapid, reproducible repeated snake...
We perform a proof-of-principle demonstration of chemically specific standoff gas sensing, in which coherent stimulated Raman signal is detected the direction anticollinear to two-color laser excitation beam traversing target volume. The proposed geometry intrinsically free space as it does not involve back-scattering (reflection) or beams at behind target. A carrying an intense mid-IR femtosecond (fs) pulse and parametrically generated picosecond (ps) UV Stokes fired forward direction. fs...
Strongly coupled nonlinear spatiotemporal dynamics of ultrashort mid-infrared pulses undergoing self-focusing simultaneously with soliton self-compression in an anomalously dispersive, highly solid semiconductor is shown to enable the generation multioctave supercontinua spectra spanning entire range and compressible subcycle pulse widths. With 7.9 μm, 150 fs, 2 μJ, 1 kHz used as a driver, 1.2 cycle supercontinuum radiation spectrum wavelengths from 3 18 μm were generated 5 mm GaAs plate....
We demonstrate a robust, all-solid-state approach for the generation of microjoule subcycle pulses in midinfrared through cascade carefully optimized parametric-amplification, difference-frequency-generation, spectral-broadening, and chirp-compensation stages. This method waveform becomes possible due to an unusual, ionization-assisted solid-state pulse self-compression dynamics, where highly efficient spectral broadening is enabled by ultrabroadband four-wave parametric amplification phase...
By combining tunable broadband pulse generation with the technique of nonlinear spectral compression we demonstrate a prototype scheme for highly selective detection air molecules by backward stimulated Raman scattering. The experimental results allow to extrapolate laser parameters required standoff sensing based on recently demonstrated atmospheric lasing.
A physical scenario whereby freely propagating mid-infrared pulses can be compressed to pulse widths close the field cycle is identified. Generation of tunable few-cycle in wavelength range from 4.2 6.8 μm demonstrated at a 1-kHz repetition rate through self-focusing-assisted spectral broadening normally dispersive, highly nonlinear semiconductor material, followed by compression regime anomalous dispersion, where dispersion-induced phase shift finely tuned adjusting overall thickness...
Optically detected electron spin resonance in fiber-coupled nitrogen-vacancy (NV) centers of diamond is used to demonstrate a fiber-optic quantum thermometry individual thermogenetically activated neurons. Laser-induced temperature variations read out from single neurons with the NV-diamond fiber sensor are shown strongly correlate fluorescence calcium-ion sensors, serving as online indicators inward Ca2+ current across cell membrane expressing transient receptor potential (TRP) cation...
We demonstrate an accurate quantitative characterization of absolute two- and three-photon absorption (2PA 3PA) action cross sections a genetically encodable fluorescent marker Sypher3s. Both 2PA 3PA this are found to be remarkably high, enabling high-brightness, cell-specific fluorescence brain imaging. Brain imaging experiments on sliced samples rat's cortical areas presented these modalities. The section Sypher3s is shown highly sensitive the level pH, pH measurements via ratiometric...
We present brain imaging experiments on rat cortical areas, demonstrating that, when combined with a suitable high-brightness, cell-specific genetically encoded fluorescent marker, three-photon-excited fluorescence (3PEF), enables subcellular-resolution, 3D that is fully compatible and readily integrable other nonlinear-optical modalities, including two-photon-fluorescence harmonic-generation microscopy. With laser excitation provided by sub-100-fs, 1.25-µm pulses, 3PEF from astrocytes their...
Polarization maps of high-order harmonics are shown to enable a full vectorial characterization petahertz electron currents generated in crystalline solid by an ultrashort laser driver. As powerful resource this methodology, analysis energy-momentum dispersion landscapes, defined the band structure, can help identify, as our shows, special directions within Brillouin zone that provide preferable basis for polarization-sensitive high-harmonic mapping anisotropic photocurrents solids.
An extended-cavity Cr:forsterite laser is integrated with a photonic-crystal fiber soliton frequency shifter and periodically poled lithium niobate spectrum compressor for simultaneous harmonic-generation coherent Raman brain imaging. Adapting the beam focusing geometry to tissue morphology shown enable complementarity enhancement in imaging by second- third-harmonic generation, as well scattering, facilitating quantitative image analysis.
We identify the conditions for coherent Raman scattering to enable generation of phase-matched, highly directional, nearly-backward-propagating light beams. Our analysis indicates a unique possibility standoff detection trace gases using their rotational and vibrational spectroscopic signals. demonstrate spatial selectivity transitions variability possible Umklappscattering implementation schemes laser sources.
The influence of the carrier-envelope phase (CEP) a pump pulse on multioctave supercontinuum (SC) generation in gas-filled anti-resonant hollow-core fiber (AR HCF) by soliton self-compression (SSC) has been explored. We have shown an octave-wide third harmonic (THG) visible-to-near-infrared range during compression down to sub-cycle duration. CEP multi-cycle provides control interference between (TH) and SC that indicates coherent synthesis with duration about 0.4 optical cycles peak power...
A short-pulse, frequency-tunable idler-wave output of a two-stage optical parametric amplifier is compressed in gas-filled antiresonance-guiding hollow-core photonic-crystal fiber to yield ultrashort field waveforms near-to-mid-infrared (near-IR/mid-IR) radiation with pulse energy up 28 μJ, peak power 4 GW, and width smoothly tunable, via gas-pressure adjustment inside the hollow fiber, all way down single cycle at ≤6.6 fs. With active carrier–envelope phase (CEP) stabilization extended its...
Abstract Cardiac arrhythmias are common disorders that can be fatal. Modern methods of treating bradyarrhythmias include the implantation pacemakers and cardioverters – defibrillators. However, implantable devices cause various complications including infectious ones, related to electrodes installed inside heart. Less invasive heart rhythm modulation could beneficial for some cohorts patients. We present an alternative approach pacing based on thermogenetics. used adeno-associated viruses...
Zero-phonon-line (ZPL) emission of nitrogen vacancies (NVs) is coupled to the guided modes solid- and hollow-core nanodiamond-doped photonic-crystal fibers (PCFs). Both types PCFs are tailored toward enhancing ZPL coupling fiber modes. In solid-core PCFs, this involves evanescent field waveguide supported by an ultrasmall core. NV spectrum matched with transmission band fiber, controlled photonic bands cladding.
A mode-locked chromium forsterite laser with output power in excess of 0.7 W, a central wavelength 1.25 μm, pulse repetition rate 29 MHz, and an pulse-width-tunable from 40 to 200 fs is demonstrated. The dynamics behind the buildup ultrashort light pulses this shown involve spectral temporal breathing due interplay gain, Kerr nonlinearity, dispersion effects. μm delivered by developed source suggests powerful tool for nonlinear-optical bio-imaging offers advantageous front end extreme-power...
Cross-correlation frequency-resolved optical gating (XFROG) based on four-wave mixing (FWM) in a gas medium is shown to enable dispersion-free characterization of few-cycle mid-infrared (mid-IR) pulses tunable within spectral range more than two octaves. The FWM XFROG technique used measure spectra and pulse shapes, as well retrieve the phase output difference-frequency generation (DFG) from 3 11 μm. With Ti:sapphire laser reference, this process maps entire tunability DFG source, spanning...
Coherent anti-Stokes Raman scattering (CARS) is used to measure the amplitude, dephasing lifetime, and parameters of optical nonlinearities phonons in a synthetic diamond film. A compact CARS apparatus demonstrated this work relies on use an unamplified 70 fs 340 mW Cr:forsterite laser output photonic-crystal fibers optimized for generation wavelength-tunable Stokes field spectral compression probe pulse.
Coherent cancellation of third-harmonic generation (THG) in a tightly focused laser beam is shown to enable label-free imaging individual neurons representative brain tissues. The intrinsic coherence buildup and combined with the nonlinear nature process enhances locality dark signal THG, translating into remarkable sharpness dark-field THG images. Unique advantages this technique for high-contrast subcellular-resolution neuroimaging are demonstrated by comparing images hippocampus...
Large-core hollow photonic-crystal fibers (PCFs) are shown to enable a fiber-format air-guided delivery of ultrashort infrared laser pulses for neurosurgery and nonlinear-optical imaging. With an appropriate dispersion precompensation, anomalously dispersive 15-μm-core PCF compresses 510-fs, 1070-nm light pulse width about 110 fs, providing peak power in excess 5 MW. The compressed output is employed induce local photodisruption corpus callosum tissues mouse brain used generate the third...