A5101967406- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- S100 Proteins and Annexins
- MRI in cancer diagnosis
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Alzheimer's disease research and treatments
- Cytokine Signaling Pathways and Interactions
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Parathyroid Disorders and Treatments
- RNA modifications and cancer
- Protein Kinase Regulation and GTPase Signaling
- Brain Tumor Detection and Classification
- Lanthanide and Transition Metal Complexes
- Cancer-related cognitive impairment studies
- Cellular transport and secretion
- RNA regulation and disease
- Radiomics and Machine Learning in Medical Imaging
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Atherosclerosis and Cardiovascular Diseases
- Computational Drug Discovery Methods
Brigham and Women's Hospital
2014-2025
Harvard University
2014-2025
Society of Nuclear Medicine and Molecular Imaging
2018-2024
Center for Systems Biology
2015
Icahn School of Medicine at Mount Sinai
2015
Massachusetts General Hospital
2015
Imaging Center
2015
Amsterdam UMC Location University of Amsterdam
2015
Copenhagen University Hospital
2015
University of Copenhagen
2015
(18)F-florbetapir is a promising imaging biomarker for cardiac light chain amyloidosis (AL) and transthyretin (ATTR). Our aim, using human autopsy myocardial specimens, was to test the hypothesis that binds specifically AL ATTR amyloid deposits.We studied sections from 30 subjects with autopsy-documented (n=10), nonamyloid controls (n=10) cold florbetapir compound digital autoradiography. Total nonspecific binding of determined maximum signal intensity values. Specific calculated by...
Alzheimer's disease (AD) is the most common cause of dementia. Neuroinflammation appears to play an important role in AD pathogenesis. Ligands 18 kDa translocator protein (TSPO), a marker for activated microglia, have been used as positron emission tomography (PET) tracers reflect neuroinflammation humans and mouse models. Here, we novel TSPO-targeted PET tracer F-GE180 (flutriciclamide) investigate differences between young old WT APP/PS1dE9 transgenic (Tg) mice. In vivo scans revealed...
Local plaque macrophage proliferation and monocyte production in hematopoietic organs promote progression of atherosclerosis. Therefore, noninvasive imaging could serve as a biomarker monitor therapeutic intervention.
Abstract Space travel will expose people to high-energy, heavy particle radiation, and the cognitive deficits induced by this exposure are not well understood. To investigate short-term effects of space we irradiated 4-month-old Alzheimer’s disease (AD)-like transgenic (Tg) mice wildtype (WT) littermates with a single, whole-body dose 10 or 50 cGy 56 Fe ions (1 GeV/u) at Brookhaven National Laboratory. At ~1.5 months post irradiation, behavioural testing showed sex-, genotype-,...
<h3>Objective</h3> To determine the value of [F-18]PBR06-PET for assessment microglial activation in cerebral gray matter patients with MS. <h3>Methods</h3> Twelve MS (7 relapsing-remitting and 5 secondary progressive [SP]) healthy controls (HCs) had standardized uptake (SUV) PET maps coregistered to 3T MRI segmented into cortical subcortical regions. SUV ratios (SUVRs) were global brain normalized. Voxel-by-voxel analysis was performed using statistical parametric mapping (SPM). Normalized...
Purpose of the Report 18 F-PBR06-PET targeting 18-kDa translocator protein can detect abnormal microglial activation (MA) in multiple sclerosis (MS). The objectives this study are to develop individualized mapping MA using F-PBR06, determine effect disease-modifying treatment (DMT) efficacy on reducing MA, and its clinical, radiological, serological correlates MS patients. Patients Methods Thirty scans were performed 22 patients (mean age, 46 ± 13 years; 16 females) 8 healthy controls (HCs)....
Abstract Glioblastoma (GBM) is the most common and deadliest form of brain tumor remains amongst difficult cancers to treat. Brevican (Bcan), a central nervous system (CNS)‐specific extracellular matrix protein, upregulated in high‐grade glioma cells, including GBM. A Bcan isoform lacking glycosylation, dg‐Bcan, found only GBM tissues. Here, dg‐Bcan explored as molecular target for In this study, d ‐peptide library screened identify small 8‐amino acid dg‐ B can‐ T argeting P eptide (BTP)...
Background and Purpose 18 F-PBR06 11 C-PBR28 are second-generation PET radioligands targeting the 18-kd translocator protein to assess microglial activation. We directly compared for detecting brain binding in multiple sclerosis (MS). Methods Six patients with MS (4 women; mean age ± SD, 32.1 4.9 [range, 23.5–37.4 years]; Expanded Disability Status Scale score 2.3 1.2 1.0–4.0]) underwent both ligands, along 3-T MRI. MRI was coregistered summed 60- 90-minute images. SUV ratios (SUVRs),...
The goal of our study is to assess the role microglial activation in MS-associated fatigue (MSAF) using [F-18]PBR06-PET.Fatigue severity was measured Modified Fatigue Impact Scale (MFIS) 12 subjects with MS (7 relapsing-remitting and 5 secondary progressive) 10 healthy control participants who underwent [F-18]PBR06-PET. MFIS provides a total score as well physical, cognitive, psychosocial subscale scores. Standardized Uptake Value (SUV) 60-90 minute frame PET maps were coregistered 3T MRI....
Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle cause physiological and behavioral impairments in rodents may pose risks human spaceflight. There is evidence that 56Fe irradiation, significant component space radiation, be more harmful males than females worsen Alzheimer's disease pathology genetically vulnerable models. Yet, research on the long-term, sex- genotype-specific effects irradiation lacking. Here, we irradiated...
Voxel-Wise Analysis of Fluoroethyltyrosine PET and MRI in the Assessment Recurrent Glioblastoma During Antiangiogenic TherapyElizabeth George1, Marie F. Kijewski1, Shipra Dubey1, Anthony P. Belanger1, David A. Reardon2, Patrick Y. Wen2, Santosh Kesari3, Laura Horky1, Mi-Ae Park1 Raymond Huang1Audio Available | Share
A 69-year-old woman with progressive short-term memory deficits was diagnosed Alzheimer disease (MMSE 26/30, CDR 0.5) and underwent PET using 18 F-PBR06, a second-generation 18-kDa translocator protein ligand, targeting brain microglia astrocytes. SUV voxel-by-voxel binding potential maps (using simplified reference tissue method cerebellar pseudo-reference region) were generated. Images showed evidence of increased glial activation in biparietal cortices (including bilateral precuneus...
Determine the effect of ofatumumab on microglial activation using [F-18]PBR06 PET targeting 18kilodalton-translocator protein (TSPO) in RMS patients.
Introduction Cortical grey (CoGM) and white matter (WM) microglial activation (MA) is involved in the pathogenesis of multiple sclerosis (MS). [F-18]PBR06 positron emission tomography (PET) targeting 18kilodalton-translocator protein (TSPO) can detect abnormal MA MS. Aims Objectives The goal this study to determine effect disease modifying treatment (DMT) efficacy on modulating extent clinical radiological correlates MS patients. Methods Thirty PET scans were performed 22 patients (13 RR, 9...
May 6, 2019April 9, 2019Free AccessMicroglial Activation in the Deep Grey Matter is Associated with Regional Atrophy and Physical Disability Multiple Sclerosis (S12.003)Tarun Singhal, Steven Cicero, Renxin Chu, Shipra Dubey, Kelsey O’Connor, Shahamat Tauhid, Marie Kijewski, Howard L. Weiner, Rohit BakshiAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.S12.003 Letters to Editor