A5105669923- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- Surfactants and Colloidal Systems
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Colorectal and Anal Carcinomas
- Spectroscopy and Chemometric Analyses
- Sarcoma Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Tuberculosis Research and Epidemiology
- Advanced Drug Delivery Systems
- Ginseng Biological Effects and Applications
- Hippo pathway signaling and YAP/TAZ
- Heavy Metals in Plants
- Chromatography in Natural Products
- Catalysis for Biomass Conversion
- Carbon dioxide utilization in catalysis
- Neutropenia and Cancer Infections
- Cancer Diagnosis and Treatment
- Plant Pathogens and Fungal Diseases
- Heavy metals in environment
- Dye analysis and toxicity
- Metal-Organic Frameworks: Synthesis and Applications
- Mesoporous Materials and Catalysis
- Dendrimers and Hyperbranched Polymers
Sichuan University
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking Union Medical College Hospital
2025
West China Hospital of Sichuan University
2025
Anhui Agricultural University
2024
Guizhou University
2023
Puer University
2019
Yunnan University
2019
State Key Laboratory of Pollution Control and Resource Reuse
2017
Nanjing University
2017
Cancer‑associated fibroblasts (CAFs), key components of the tumor stroma, can regulate tumorigenesis by altering microenvironment in variety ways to promote angiogenesis, recruit inflammatory immune cells and remodel extracellular matrix. Using a murine xenograft model colon carcinoma, present study observed that oxaliplatin increased accumulation CAFs stimulated production cytokines associated with CAFs. When was combined small‑molecule dipeptidyl peptidase inhibitor PT‑100, which inhibits...
We have found that not only block copolymers but also ionomers can self-assemble in a selective solvent to form surfactant-free nanoparticles. The self-assembly be induced by chemical reaction, polymer−polymer complexation, and microphase inversion addition the temperature. A recently developed microwave method for preparation of uniform polymeric nanoparticles is reviewed. Our results revealed given dispersion, particle surface area occupied per stabilizer (surfactant, polymer chains, ionic...
ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTNovel Surfactant-Free Stable Colloidal Nanoparticles Made of Randomly Carboxylated Polystyrene IonomersMei Li, Ming Jiang, Lei Zhu, and Chi WuView Author Information Department Macromolecular Science, Fudan University, Shanghai 200433, China, Chemistry, The Chinese University Hong Kong, KongCite this: Macromolecules 1997, 30, 7, 2201–2203Publication Date (Web):April 1997Publication History Received4 October...
Objectives: Population with Latent tuberculosis infection (LTBI) is the principal source of active (ATB) cases. The identification reliable diagnostic biomarkers critical for prevention and control progression from LTBI to ATB. aim this study screen that can distinguish ATB patients by using a comprehensive bioinformatics analysis strategy. Methods: transcriptomic datasets were obtained GEO database. Hub genes signal pathways differentiating latent TB, identified strategy comprising Weighted...
Abstract 5′‐Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncoprotein, the regulatory effects of which have not been well characterized. This study aimed to investigate expression profile and functional regulation NT5DC2 its potential interplay with TEAD4 in leiomyosarcoma (LMS). Bioinformatic analysis was conducted using data from The Cancer Genome Atlas (TCGA) Genotype‐Tissue Expression (GTEx) program. LMS cell lines SK‐LMS‐1 SK‐UT‐1 were used for both vitro vivo analysis. Results...
Summary Numerous herbivore‐induced plant volatiles (HIPVs) play important roles in defense. In tea plants ( Camellia sinensis ), (Z)‐3‐hexenyl acetate (3‐HAC) has been characterized as associated with resistance to herbivores. To date, how biosynthesize and regulate 3‐HAC resist herbivores remain unclear. Based on transcriptomes assembled from Ectropis obliqua‐ fed leaves, a cDNA encoding BAHD acyltransferase, namely CsCHAT1 , was highly induced leaves E. obliqua . Enzymatic assays showed...
11572 Background: In patients with advanced soft tissue sarcoma (STS) who have achieved disease control after anthracycline-based chemotherapy, maintenance therapy is being explored. This study evaluated the efficacy and safety of toripalimab (a monoclonal antibody against programmed cell death-1 receptor) combined anlotinib multitargeted tyrosine kinase inhibitor) as a treatment. Methods: Patients STS at least four cycles first-line chemotherapy were enrolled in this single-arm, phase 2...
Abstract Background This study aims to assess the tolerability and safety of DQTM tablet, which contains a complex mixture Salvia miltiorrhiza salvianolic acids Panax notoginseng saponins. Methods A double-blind, randomized, placebo-controlled phase I dose escalation was conducted in 84 healthy volunteers. In single ascending study, active ingredients were administered various doses (90, 270, 540, 1080, 1800, 2880, 4320 or 5760 mg) 60 subjects cohorts 1–8. multiple at 360, 720 2160 mg twice...
Tin triflate (Sn(OTf)2) shows good catalytic performance toward the conversion of glucose into α-hydroxyesters (AHEs). Here, we report mechanisms for β-d-glucopyranose AHEs in methanol solution with Sn(OTf)2 at PBE0/6-311++G(d,p), def2-TZVP theoretical level, combining ESI-MS verification. From alcoholysis solution, active species involves both [Sn(CH3O)(CH3OH)]+ and [Sn(OTf)(CH3OH)2]+ Lewis acids, together [CH3OH2]+ Bro̷nsted acid. There are six vital kinds reaction stages, i.e.,...
11561 Background: Both the microtubule-dynamics inhibitor eribulin and multi-targeted tyrosine kinase anlotinib exhibit single-agent anti-tumor activity in previously treated soft tissue sarcoma (STS). This study aimed to evaluate efficacy safety of combination treatment patients with advanced STS. Methods: In this multi-center phase II (ERAS), who relapsed/progressed after anthracycline chemotherapy or were not candidates for such included. Patients received (1.1 mg/m² intravenously on days...
Abstract Focal adhesion kinase (FAK) is a non-receptor tyrosine that integrates signals from integrins and growth factor receptors. FAK has been reported to play role in the regulation of cell survival, growth, spreading, migration invasion. Overexpression mRNA and/or protein documented many human tumors, including cancers breast, colon, thyroid, prostate. regulated activated by phosphorylation on multiple residues. More significantly, there evidence phosphorylated increased malignant...
In a solution of sorbitol (SBT) and Ga(OTf)3 compounds, the coordination to [Ga(OTf)n]3-n (n = 0-3) has been investigated, using both ESI-MS spectra density functional theory (DFT) calculations at M06/6-311++g(d,p), aug-cc-pvtz level polarized continuum model (PCM-SMD). solution, most stable conformer includes three intramolecular H-bonds, i.e., O2H⋯O4, O4H⋯O6, O5H⋯O3. Through spectra, in tetrahydrofuran SBT five main species are observed, [Ga(SBT)]3+, [Ga(OTf)]2+, [Ga(SBT)2]3+,...
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