Egor A. Nikiforov

ORCID: 0000-0003-1021-1664
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Research Areas
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Solid-state spectroscopy and crystallography
  • Advanced NMR Techniques and Applications
  • Inorganic Fluorides and Related Compounds
  • Fluorine in Organic Chemistry
  • NMR spectroscopy and applications
  • Synthesis and Catalytic Reactions
  • Luminescence and Fluorescent Materials
  • Catalytic C–H Functionalization Methods
  • DNA and Nucleic Acid Chemistry
  • Molecular Spectroscopy and Structure
  • Chemical and Physical Studies
  • Methane Hydrates and Related Phenomena
  • Atomic and Subatomic Physics Research
  • Synthesis and Biological Evaluation
  • Thermodynamic properties of mixtures
  • Radical Photochemical Reactions
  • Engineering Technology and Methodologies
  • Laser Design and Applications
  • Pulsed Power Technology Applications
  • Process Optimization and Integration
  • Synthesis and Reactions of Organic Compounds
  • Recycling and utilization of industrial and municipal waste in materials production
  • Magnetic and Electromagnetic Effects

Ural Federal University
2019-2025

Kazan Federal University
2012

Pedagogical University
2001

N.D. Zelinsky Institute of Organic Chemistry
1974

Abstract The C–H functionalization strategy was first applied to the Cu-mediated radical arylation reactions of triazolotriazines with aromatic diazonium salts. A series C(3)-modified triazolo[5,1-c][1,2,4]triazines were obtained in yields up 80% under mild conditions. nature reaction mechanism established by TEMPO trap experiments. developed method is characterized its versatile application opportunities, particularly it allows C(3)-arylated azoloazine-derived compounds various...

10.1055/s-0043-1773510 article EN Synthesis 2025-01-08

The synthesis of inhibitors for oxidative stress-associated destructive processes based on 2H-imidazole-derived phenolic compounds affording the bifunctional in good-to-excellent yields was reported. In particular, a series organic molecules 5-aryl-2H-imidazole family various architectures bearing both electron-donating and electron-withdrawing substituents aryl fragment along with different arrangements hydroxy groups polyphenol moiety, namely derivatives phloroglucinol, pyrogallol,...

10.3390/molecules26216534 article EN cc-by Molecules 2021-10-29

The strategy of the nucleophilic substitution hydrogen (SNH) was first applied for metal-free C-H/C-H coupling reactions 4H-imidazole 3-oxides with indoles. As a result, series novel bifunctional azaheterocyclic derivatives were obtained in yields up to 95%. In silico experiments on molecular docking performed evaluate binding possibility synthesized small molecules selected biotargets (BACE1, BChE, CK1δ, AChE) associated pathogenesis neurodegenerative diseases. To assess cytotoxicity...

10.3390/pr11030846 article EN Processes 2023-03-12

A synthetic strategy based on reactions of cyclic imine oxides, namely 2H-imidazole 1-oxides, with thiophenols mediated by acetyl chloride was successfully applied as a convenient tool to obtain series novel azaheterocyclic molecules, including water-soluble hydrochloride forms. Optimized reaction conditions found herein for the nucleophilic substitution hydrogen (SNH) in non-aromatic substrates via “addition-elimination” (SNH AE) scheme enabled 15 arylthiolated 2H-imidazoles be prepared...

10.3390/chemistry5030100 article EN cc-by Chemistry 2023-06-24

The methodology of nucleophilic substitution hydrogen (SNH) was successfully applied as a convenient synthetic tool to afford azaheterocyclic derivatives phenols various architectures. A series 26 novel imidazole-linked polyphenolic compounds were first prepared in 72-95% yields through the direct metal-free C-H/C-H coupling polyphenols with 2H-imidazole 1-oxides. Comprehensive studies on reaction condition optimization, scope, and limitations enabled development straightforward method...

10.1021/acs.joc.1c01796 article EN The Journal of Organic Chemistry 2021-09-14

Abstract A convenient method for the synthesis of new highly in non-polar solvents soluble photoactive pentafluorophenyl-substituted and extended alkoxyphenyl-substituted 2,2′-bipyridines is reported. The synthetic strategy preparation such ligands involves a sequence several structural transformations, as O-alkylation, nucleophilic substitution hydrogen (SN H) 1,2,4-triazine precursors via ‘addition–elimination’ scheme, subsequent conversion obtained 1,2,4-triazines into by means...

10.1055/a-1500-1343 article EN Synthesis 2021-05-05

Abstract A four-stage method for the synthesis of 2H-imidazole-derived push-pull fluorophores was developed. The synthesized compounds are characterized by absorption in range 250–400 nm, emission up to 617 and quantum yields 99%. Compounds bearing a tetraphenylethylene fragment demonstrated AIE effect solution with water fraction fw >90% significant increase intensity 20 times 22%. ICT states these were confirmed calculating excited state dipole moments (>23D). reported synthetic...

10.1055/s-0042-1751561 article EN Synthesis 2024-02-22

Ակնարկը նվիրված է արդի օրգանական քիմիայի զարգացման կարևորագույն ուղղություններից մեկին՝ մոլեկուլային համակարգերի նպատակաուղղված նախագծմանը և ստեղծմանը։ Նմանատիպ համակարգերը անհրաժեշտ են ազահետերոցիկլային միացությունների հիման վրա նոր դեղերի, ինչպես նաև էլեկտրոնիկայում կիրառվող «խելացի» նյութերի ստեղծման համար։ C-H ֆունկցիոնալացման եղանակը, որը որպես սինթեզի ինքնուրույն ուղղություն առաջարկվել մշակվել Ուրալյան դպրոցի քիմիկոսների կողմից, հնարավորություն ընձեռում խուսափելու հալոգենների կամ այլ...

10.54503/0515-9628-2024.77.1-86 article RU Chemical Journal of Armenia 2024-04-23

Разработка новых фармакологических веществ для коррекции эндотелиальной дисфункции (ЭД) является перспективным направлением в фармакологии. В данном исследовании оценены острая токсичность, эндотелио- и кардиопротекторные свойства оригинальных малых молекул — 5-(пиррол-2-ил)- 5-морфолинозамещенных производных 2H-имидазола. Фармакологическую активность исследовали на модели L-NAME (N-Nitroarginine Methyl Ester) индуцированной ЭД, соединений оценивали мышах путем проведения нагрузочных проб in...

10.30906/0869-2092-2024-87-10-31-37 article RU Экспериментальная и клиническая фармакология 2024-11-05

10.1007/bf00751968 article EN Journal of Structural Chemistry 1969-01-01
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