- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Solid-state spectroscopy and crystallography
- Advanced NMR Techniques and Applications
- Inorganic Fluorides and Related Compounds
- Fluorine in Organic Chemistry
- NMR spectroscopy and applications
- Synthesis and Catalytic Reactions
- Luminescence and Fluorescent Materials
- Catalytic C–H Functionalization Methods
- DNA and Nucleic Acid Chemistry
- Molecular Spectroscopy and Structure
- Chemical and Physical Studies
- Methane Hydrates and Related Phenomena
- Atomic and Subatomic Physics Research
- Synthesis and Biological Evaluation
- Thermodynamic properties of mixtures
- Radical Photochemical Reactions
- Engineering Technology and Methodologies
- Laser Design and Applications
- Pulsed Power Technology Applications
- Process Optimization and Integration
- Synthesis and Reactions of Organic Compounds
- Recycling and utilization of industrial and municipal waste in materials production
- Magnetic and Electromagnetic Effects
Ural Federal University
2019-2025
Kazan Federal University
2012
Pedagogical University
2001
N.D. Zelinsky Institute of Organic Chemistry
1974
Abstract The C–H functionalization strategy was first applied to the Cu-mediated radical arylation reactions of triazolotriazines with aromatic diazonium salts. A series C(3)-modified triazolo[5,1-c][1,2,4]triazines were obtained in yields up 80% under mild conditions. nature reaction mechanism established by TEMPO trap experiments. developed method is characterized its versatile application opportunities, particularly it allows C(3)-arylated azoloazine-derived compounds various...
The synthesis of inhibitors for oxidative stress-associated destructive processes based on 2H-imidazole-derived phenolic compounds affording the bifunctional in good-to-excellent yields was reported. In particular, a series organic molecules 5-aryl-2H-imidazole family various architectures bearing both electron-donating and electron-withdrawing substituents aryl fragment along with different arrangements hydroxy groups polyphenol moiety, namely derivatives phloroglucinol, pyrogallol,...
The strategy of the nucleophilic substitution hydrogen (SNH) was first applied for metal-free C-H/C-H coupling reactions 4H-imidazole 3-oxides with indoles. As a result, series novel bifunctional azaheterocyclic derivatives were obtained in yields up to 95%. In silico experiments on molecular docking performed evaluate binding possibility synthesized small molecules selected biotargets (BACE1, BChE, CK1δ, AChE) associated pathogenesis neurodegenerative diseases. To assess cytotoxicity...
A synthetic strategy based on reactions of cyclic imine oxides, namely 2H-imidazole 1-oxides, with thiophenols mediated by acetyl chloride was successfully applied as a convenient tool to obtain series novel azaheterocyclic molecules, including water-soluble hydrochloride forms. Optimized reaction conditions found herein for the nucleophilic substitution hydrogen (SNH) in non-aromatic substrates via “addition-elimination” (SNH AE) scheme enabled 15 arylthiolated 2H-imidazoles be prepared...
The methodology of nucleophilic substitution hydrogen (SNH) was successfully applied as a convenient synthetic tool to afford azaheterocyclic derivatives phenols various architectures. A series 26 novel imidazole-linked polyphenolic compounds were first prepared in 72-95% yields through the direct metal-free C-H/C-H coupling polyphenols with 2H-imidazole 1-oxides. Comprehensive studies on reaction condition optimization, scope, and limitations enabled development straightforward method...
Abstract A convenient method for the synthesis of new highly in non-polar solvents soluble photoactive pentafluorophenyl-substituted and extended alkoxyphenyl-substituted 2,2′-bipyridines is reported. The synthetic strategy preparation such ligands involves a sequence several structural transformations, as O-alkylation, nucleophilic substitution hydrogen (SN H) 1,2,4-triazine precursors via ‘addition–elimination’ scheme, subsequent conversion obtained 1,2,4-triazines into by means...
Abstract A four-stage method for the synthesis of 2H-imidazole-derived push-pull fluorophores was developed. The synthesized compounds are characterized by absorption in range 250–400 nm, emission up to 617 and quantum yields 99%. Compounds bearing a tetraphenylethylene fragment demonstrated AIE effect solution with water fraction fw >90% significant increase intensity 20 times 22%. ICT states these were confirmed calculating excited state dipole moments (>23D). reported synthetic...
Ակնարկը նվիրված է արդի օրգանական քիմիայի զարգացման կարևորագույն ուղղություններից մեկին՝ մոլեկուլային համակարգերի նպատակաուղղված նախագծմանը և ստեղծմանը։ Նմանատիպ համակարգերը անհրաժեշտ են ազահետերոցիկլային միացությունների հիման վրա նոր դեղերի, ինչպես նաև էլեկտրոնիկայում կիրառվող «խելացի» նյութերի ստեղծման համար։ C-H ֆունկցիոնալացման եղանակը, որը որպես սինթեզի ինքնուրույն ուղղություն առաջարկվել մշակվել Ուրալյան դպրոցի քիմիկոսների կողմից, հնարավորություն ընձեռում խուսափելու հալոգենների կամ այլ...
Разработка новых фармакологических веществ для коррекции эндотелиальной дисфункции (ЭД) является перспективным направлением в фармакологии. В данном исследовании оценены острая токсичность, эндотелио- и кардиопротекторные свойства оригинальных малых молекул — 5-(пиррол-2-ил)- 5-морфолинозамещенных производных 2H-имидазола. Фармакологическую активность исследовали на модели L-NAME (N-Nitroarginine Methyl Ester) индуцированной ЭД, соединений оценивали мышах путем проведения нагрузочных проб in...