Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients explore divergent patterns across different stages AMD. Methods: Thirty-eight were prospectively enrolled stratified by disease severity: eAMD, iAMD, nAMD, aAMD. Comprehensive ophthalmological...

Purpose – Quantitative instruments to assess patient safety culture have been developed recently and a few review articles published. Measuring enables healthcare managers staff improve behaviours outcomes for patients staff. The study aims determine the AHRQ Hospital Survey on Patient Safety Culture (HSPSC) Portuguese version's validity reliability. Design/methodology/approach A missing-value analysis item was performed identify problematic items. Reliability analysis, inter-item...

The growing digitization of healthcare institutions and its increasing dependence on Internet infrastructure has boosted the concerns related to data privacy confidentiality. These have been challenged with specific issues, namely sensitivity data, specificity networked equipment, heterogeneity professionals (nurses, doctors, administrative staff other) IT skills they have. In this paper we present results obtained a study made evaluating their awareness level information security, by...

Introducción El desarrollo de esta propuesta se basa en la necesidad incorporar un modelo atención con alta evidencia científica y excelente experiencia otros países. Además ser una alternativa inexistente red asistencial pública actualmente, es estrategia alineada los objetivos nacionales e internacionales establecer el personalizada integral del parto, para positiva. Objetivos Demostrar factibilidad económica implementación Centro Nacimiento dentro Hospital Barros Luco Trudeau (HBLT),...

Este estudo investigou o impacto do modelo educacional inserido no espaço tecnológico, com foco nas vantagens, benefícios e riscos ambiente digital para a educação. O objetivo geral foi analisar as implicações uso das tecnologias educacionais metodologias ativas processo de ensino-aprendizagem. A pesquisa conduzida forma bibliográfica, base em uma revisão literatura relevante sobre ferramentas digitais aplicadas à educação, os desafios digital. Durante desenvolvimento, observou-se que...

Abstract Introduction The positive impact of cardiac rehabilitation in terms improvement functional capacity, quality life, and prognosis is well established. However, not all patients respond adequately to the programs. Purpose objective this work determine rate predictors non-response a program capacity. Additionally, it aims evaluate on prognosis. Methods Prospective observational single-center study including enrolled phase II CR between 2016 2024. Clinical, imaging, laboratory CPET data...

Digital exposure to the Internet among younger generations, notwithstanding their digital abilities, has increased and raised alarm regarding need intensify education on cybersecurity in schools. Understanding of human factor its influence children, namely attitudes behaviors online, is pivotal reinforce awareness towards cyberattacks, promote citizenship. This paper aims present an integrated cyberawareness strategy composed three major steps: (1) Cybersecurity attitude behavior assessment,...

DNA methylation is involved in Diabetic Retinopathy progression showing a metabolic memory mechanism. However, the association of methyltransferase with diabetic macular edema still unknown. We aimed to describe differences gene expression patients different responses.A total 27 patients, aged 59-90 years, were prospectively enrolled this cross-sectional study. The participants classified into control group (CG, n = 11), responders (rDME, 9) and non-responder (nrDME, 7) after anti-vascular...

A common task in analyzing microarray data is to determine which genes are differentially expressed across two (or more) kind of tissue samples or submitted under experimental conditions. Several statistical methods have been proposed accomplish this goal, generally based on measures distance between classes. It well known that biological heterogeneous because factors such as molecular subtypes genetic background often unknown the experimenter. For instance, experiments involve...

The use of technology has proven to be a powerful tool in the fight against COVID-19 and its variants concern (Gamma, Beta, Alpha, Delta, Omicron). urgency responding this worldwide pandemic accelerated development monitoring systems contact tracing applications. Without technology’s contribution, adverse effects on humanity economically, socially, psychologically would even more devastating. This study aimed translate, adapt, validate Unified Theory Acceptance Use Technology (UTAUT) model...

To identify the prevalence of major and minor electrocardiographic abnormalities their association with main risk factors for cardiovascular disease in a population province Bengo, northern Angola.A cross-sectional community-based study was conducted representative random sample stratified by sex age selected. In total, 2379 black individuals were included final analysis. A standard 12-lead ECG recorded from all participants, analyzed processed University Glasgow software coding Minnesota...

Reports of essential fatty acid deficiency (EFAD) in patients receiving parenteral nutrition (PN) and a composite lipid (mixed oil intravenous emulsion [MO ILE]) are predominantly when managed by restriction. The objective this study was to determine the prevalence EFAD with intestinal failure (IF) who PN dependent without restriction.We retrospectively evaluated patients, ages 0-17 years, followed our rehabilitation program between November 2020 June 2021 dependency index (PNDI) >80% on MO...

Cybersecurity has a major impact on the healthcare sector, mainly due to sensitive data and vital medical devices that, when an attack occurs, may compromise life, safety, well-being of patients. However, those institutions fail implementing correct system protection policies providing adequate programs for cybersecurity training raising awareness. Healthcare professionals develop their academic courses focusing best care patients, studying guidelines, treatment protocols, diagnostic...

Sickle cell anemia (SCA) is an inherited hematological disorder and a serious global health problem, especially in Sub-Saharan Africa. Although hydroxyurea (HU) the leading treatment for patients with SCA, its effects on gut microbiome have not yet been explored. In this context, aim of study was to investigate association by characterizing Angolan SCA pediatric population before after 6 months HU treatment. A total 66 stool samples were obtained sequenced 16S rRNA gene (V3-V4 regions)....

Sickle cell anemia (SCA) is an inherited disease affecting the hemoglobin that particularly common in sub-Saharan Africa. Although monogenic, phenotypes are markedly heterogeneous terms of severity and life span. Hydroxyurea still most treatment for these patients, response to highly variable seems be trait. Therefore, identifying variants might predict hydroxyurea important patients who will have a poorer or non-response treatment, ones more prone suffer from severe side effects. In present...

Uma experiência com a Global Trigger Tool no estudo dos eventos adversos num serviço de medicinaAn experience with the for study of adverse events in medical ward Una experiencia con la en el estudio un servicio

Studies on the electrocardiogram findings in African pregnant women are limited. There is no information available literature electrocardiographic parameters of Angolan women.The aim this study was to describe with normal pregnancies Bengo Province, Angola.This a community-based cross-sectional design conducted between September 2013 and March 2014 Bengo. The involved 114 black women, compared paired control group comprising 120 non-pregnant aged 15 42 years. A 12-lead rhythm strip were...

Gut microbiota is intrinsically associated with the immune system and can promote or suppress infectious diseases, especially viral infections. This study aims to characterize compare profile of infected patients SARS-CoV-2 (milder severe symptoms), non-infected people, recovered patients. a national, transversal, observational, multicenter, case-control that analyzed COVID-19 mild symptoms at home, hospital, in intensive care unit, already recovered, healthy volunteers cohabiting DNA was...

Metabolic myopathies are a diverse group of rare genetic disorders associated with recurrent episodes rhabdomyolysis, induced by triggers such as fever or exercise. In these disorders, the energetic metabolism is compromised resulting in damage muscle cells. The diagnosis can be challenging but essential for correct treatment. Carnitine palmitoytransferase II (CPT-II) deficiency most common long-chain fatty acid oxidation defect, adulthood form requiring additional external triggers. authors...

Studies on the normal electrocardiogram limits in African populations are limited, especially sub-Saharan Africa. There is no literature describing ECG Angolans. The aim of this study to establish for adult Angolans, without established heart disease, stratified by gender and age. A cross-sectional was performed, involving 2179 participants from a population northern Angola, aged between 15 74 years. 12‑lead rhythm strip were recorded all analysed processed University Glasgow software...

Benefits of regular physical exercise were demonstrated as preventive and coadjuvant nonpharmacological anticancer therapy. However, the role in modulating prostate cancer behavior has yet to be established.Prostate tumors induced C57BL/6 male mice (n = 28) by subcutaneous inoculation a suspension murine androgen-independent RM1 cells (1.5 × 105 cells/500 μL phosphate-buffered saline) dorsal region. Mice randomly allocated into 2 study groups: sedentary tumor-induced 14) exercised 14)....

Introducing distance learning within higher education institutions (HEIs) is a key societal issue, especially in the health sector, due to its vivo nature. Public policies play an important role these digital environments. This study aims identify determinants influencing national public that foster transformation Health HEIs Portugal. A prospective survey, using structural analysis of Godet’s method, conducted, and data are gathered from different sector stakeholders. Despite efforts...