A5026125789- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Water Treatment and Disinfection
- Legionella and Acanthamoeba research
- Synthesis and Biological Evaluation
- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Groundwater and Isotope Geochemistry
- Cerebrospinal fluid and hydrocephalus
- Antimicrobial Resistance in Staphylococcus
- Fecal contamination and water quality
- Water Quality and Pollution Assessment
- Vibrio bacteria research studies
- Wastewater Treatment and Reuse
Centers for Disease Control and Prevention
2020-2023
Environmental Protection Agency
2018-2022
National Center for Emerging and Zoonotic Infectious Diseases
2020
Abstract Background The COVID-19 pandemic has resulted in unprecedented healthcare challenges, and been linked to secondary infections. Candidemia, a fungal healthcare-associated infection, described patients hospitalized with severe COVID-19. However, studies of candidemia coinfection have limited sample size geographic scope. We assessed differences without diagnosis. Methods conducted case-level analysis using population-based surveillance data collected through the Centers for Disease...
Olorofim is a novel antifungal drug that belongs to the orotomide class which inhibits fungal dihydroorotate dehydrogenase (DHODH), thus halting pyrimidine biosynthesis and ultimately DNA synthesis, cell growth division. It being developed at time when many invasive infections exhibit resistance or have limited treatment options. The goal of this study was evaluate in vitro effectiveness olorofim against large collection recently isolated, clinically relevant American mold isolates. In...
Scedosporium spp. and Lomentospora prolificans are an emerging group of fungi refractory to current antifungal treatments. These species largely affect immunocompromised individuals but can also be lung colonizers in cystic fibrosis patients. Although apiospermum is thought the predominant species, has been expanded a complex. The distribution within S. complex other closely related United States unknown. Here, we used β-tubulin ITS sequences identify 37 isolates level. as well 13 L. were...
The spread of antibiotic resistance genes (ARGs) in the aquatic environment is an emerging concern interest protecting public health. Stemming environmental dissemination ARGs will require a better understanding sources and drivers water environment. In this study, we used direct measurement sewage-associated molecular markers, class 1 integron gene, standard quality parameters, watershed characteristics to evaluate urban impacted by gradient human activities. Quantitative polymerase chain...
Coliphages can indicate contamination of recreational waters and previous studies show that sunlight is important in altering densities coliphages, other indicator microorganisms, pathogens aquatic environments. Here, we report on laboratory light-induced inactivation two coliphage groups—male-specific (F+) somatic coliphage—under various conditions phosphate-buffered water (PBW). Strains isolated from wastewater treatment facilities strains (MS2 phiX174 coliphages) were evaluated....
Candida auris is a multidrug-resistant yeast that causes severe invasive infections among patients in health care facilities. C. was first reported 2009 after being isolated from the ear canal of patient Japan and decade since has become an emerging global pathogen concern, with increasing prevalence (1–2). Multidrug resistance, high mortality rates, persistence environment, transmission between are many challenges posed by this (2–6). Patients colonized can remain asymptomatic for months at...
Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing 24 collected from 18 patients in U.S. healthcare facilities California. Single-nucleotide polymorphism (SNP) differences between patient ranged 187 to 70 829 SNPs. For five with multiple isolates, calculated within-host diversities. Three had a diversity that 4 10 SNPs and two 2...