A5024832935- Membrane Separation Technologies
- interferon and immune responses
- Cell death mechanisms and regulation
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Membrane Separation and Gas Transport
- Membrane-based Ion Separation Techniques
- Ubiquitin and proteasome pathways
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Covalent Organic Framework Applications
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Graphene and Nanomaterials Applications
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Organ Transplantation Techniques and Outcomes
- Electrochemical sensors and biosensors
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
Shandong University
2016-2025
Chongqing Normal University
2025
Qilu Hospital of Shandong University
2024
Ocean University of China
2005-2023
Shandong Provincial Hospital
2013-2022
Shandong First Medical University
2002-2022
Qingdao University of Science and Technology
2022
Harvard University
2011-2012
Beth Israel Deaconess Medical Center
2011-2012
Institute of Immunology
2007
The NLRP3 inflammasome has a fundamental role in host defence against microbial pathogens and its deregulation may cause diverse inflammatory diseases. protein expression is rate-limiting step for activation, thus must be tightly controlled to maintain immune homeostasis avoid detrimental effects. However, how regulated remains largely unknown. In this study, we identify E3 ubiquitin ligase TRIM31 as feedback suppressor of inflammasome. directly binds NLRP3, promotes K48-linked...
Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as potential approach for tumor treatment. However, emerging evidence indicates that hepatocellular carcinoma (HCC) cells are generally resistant to ferroptosis the underlying molecular mechanism poorly understood. Here, our study confirms S100 calcium binding protein P (S100P), which significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ferroptosis....
Extracellular adenosine triphosphate (ATP) is known to boost immune responses in the tumor microenvironment but might also contribute directly cancer cell death. CD39/ENTPD1 dominant ectonucleotidase expressed by endothelial cells and regulatory T catalyzes sequential hydrolysis of ATP AMP that further degraded CD73/ecto-5'-nucleotidase. We have previously shown deletion Cd39 results decreased growth transplanted tumors mice, as a result both defective angiogenesis heightened innate...
GO-interlayered OSN membrane with ultrasmooth, ultrathin, high cross-linking degree skin layer excellent solvent resistance.
// Xiaomin Ma 1 , Pengbo Guo Yumin Qiu Kun Mu 2 Lihui Zhu Wei Zhao Tao Li 3 Han Department of Immunology, Shandong University School Medicine, Jinan 250012, China Pathology, Gastroenterology, Provincial Hospital Affiliated with University, 250021, Correspondence to: Han, email: hanlihui@sdu.edu.cn Keywords: absent in melanoma 2, inflammasome, hepatocellular carcinoma, mammalian target rapamycin, tumor progression Received: January 06, 2016 Accepted: April 19, Published: May 04, ABSTRACT...
Resistance to anoikis and Epithelial-mesenchymal transition (EMT) are two processes critically involved in cancer metastasis. In this study, we demonstrated that after anchorage deprival, hepatocellular carcinoma (HCC) cells not only resisted anoikis, but also exhibited EMT process. Microarray expression profiling revealed of miR-424-5p was significantly decreased anoikis-resistant HCC cells. Ectopic overexpression sufficient reverse resistance block process inhibit malignant behaviors...
Unique change of circulating microRNAs (miRNAs) was recognized to occur in early oncogenesis, which conferred it the potential as biomarkers for detection cancer. However, its diagnostic capability hepatocellular carcinoma (HCC) has not been fully understood. In this study, microarray analysis applied screen initial candidate miRNA from both supernatants anoikis-resistant cellular models and sera samples HCC patients. The selected differentially expressed miRNAs were further verified 115...
PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity.
Abstract Liver cancer is associated with chronic inflammation, which linked to immune dysregulation, disordered metabolism, and aberrant cell proliferation. Nucleoside triphosphate diphosphohydrolase-1; (CD39/ENTPD1) an ectonucleotidase that regulates extracellular nucleotide/nucleoside concentrations by scavenging nucleotides ultimately generate adenosine. These properties inhibit antitumor responses promote angiogenesis, being permissive for the growth of transplanted tumors. Here we show...
NOD-like receptor family, pyrin domain containing 3 and 1 (NLRP3 NLRP1) inflammasomes are molecular platforms that sense the damage or danger signals of cells. We investigated whether NLRP3/NLRP1 involved in pathogenesis progression systemic lupus erythematosus (SLE).Expressions inflammasome components at mRNA protein levels peripheral blood mononuclear cells (PBMC) from patients with SLE healthy controls were by quantitative real-time transcription PCR Western blot, respectively....
Abstract Nucleotide binding oligomerization domain 2 (NOD2) is a recognized innate immune sensor which can initiate potent response against pathogens. Many sensors have been reported to be of great importance in carcinogenesis. However, the role NOD2 cancer not well understood. Here we investigated development hepatocellular carcinoma (HCC). We demonstrated that deficiency promoted hepatocarcinogenesis N -nitrosodiethylamine (DEN)/carbon tetrachloride (CCl 4 ) induced HCC mice model and...