A5049508470- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 and healthcare impacts
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Acute Myocardial Infarction Research
- Inflammatory Biomarkers in Disease Prognosis
- Brain Metastases and Treatment
- Endoplasmic Reticulum Stress and Disease
- Diagnosis and treatment of tuberculosis
- Intraperitoneal and Appendiceal Malignancies
European Institute of Oncology
2013-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2023
Grupo Español de Tumores Neuroendocrinos
2017
University of Pavia
2010
Abstract Excessive activation of blood coagulation and neutrophil accumulation have been described in several human cancers. However, whether hypercoagulation neutrophilia are linked involved cancer development is currently unknown. Here we show that spontaneous intestinal tumorigenesis correlates with the low-density neutrophils a pro-tumorigenic N2 phenotype unprompted extracellular traps (NET) formation. We find increased circulating lipopolysaccharide induces upregulation complement C3a...
Importance The assessment of the risk venous thromboembolism (VTE) among outpatients with cancer represents an unsolved topic. Current international guidelines recommend primary prophylaxis for patients at intermediate to high VTE, indicated by a Khorana score 2 or more. A previous prospective study developed ONKOTEV score, 4-variable model (RAM) consisting more than 2, metastatic disease, vascular lymphatic compression, and VTE event. Objective To validate as novel RAM assess cancer....
Background: In anal cancer, there are no markers nor other laboratory indexes that can predict prognosis and guide clinical practice for patients treated with concurrent chemoradiation. this study, we retrospectively investigated the influence of immune inflammation indicators on treatment outcome cancer undergoing chemoradiotherapy. Methods: All had a histologically proven diagnosis squamous cell carcinoma canal/margin chemoradiotherapy according to Nigro’s regimen. Impact pre-treatment...
Anal cancer is a rare disease with an increasing incidence worldwide but, unfortunately, even today the scientific community still has limited knowledge and options of treatment. More than 50% patients anal presenting at diagnosis locoregional have good chances cure chemoradiotherapy (CT-RT). However, once develop metastatic spread, prognosis very poor. Human papillomavirus (HPV) present in more 80% cancers while multiple etiologic connections between HPV infection already been well...
Background and Aims: The standard treatment of non-metastatic anal squamous cell carcinoma (ASCC) consists chemotherapy with mitomycin (MMC) plus 5-fluorouracil (5FU) for 1–2 cycles concomitant pelvic radiotherapy. Subsequent studies introduced cisplatin (CDDP) combined 5FU, unclear results. We evaluated the doublet capecitabine (C) CDDP as a possible alternative to MMC-5FU regimen intensity-modulated radiation therapy (IMRT). Patients Methods: carried out retrospective study on 67 patients...
The Coronavirus disease-19 (COVID-19) pandemic dramatically impacted on oncologic patients' care. Since the introduction of vaccines and demonstration their benefit frail patients, COVID-19 vaccinations were indicated also for population. However, data about impact anticancer-treatments timing between systemic therapy de-livery not available. We aimed to evaluate potential factors influencing outcome vaccination in cancer patients. 
 prospectively collected patients undergoing with...
Introduction: In patients with LARC, neoadjuvant CT-RT followed by curative surgery is the standard of care. Risk-adopted treatment based on MRI-predicting local T and N stage, radial margins vascular involvement while no molecular predictive markers are available. present prospective study, we investigated role serum ctDNA in LARC. Methods: Patients diagnosis LARC (T3-T4, N0 or any T, N+, M0) adenocarcinoma receiving capecitabine concomitant to 50,4 Gy after 8-10 weeks surgery, included. 18...
The coronavirus disease-19 (COVID-19) pandemic dramatically impacted oncological patients' care. Since the introduction of vaccines and demonstration their benefit on frail patients, COVID-19 vaccinations were indicated to also be beneficial population. However, data about impact anticancer-treatments timing between systemic therapy delivery not available. We aimed evaluate potential factors influencing outcome vaccination in cancer patients. prospectively collected patients undergoing with...