A5052467333- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Genetically Modified Organisms Research
- Polyomavirus and related diseases
- CAR-T cell therapy research
- Molecular Biology Techniques and Applications
- melanin and skin pigmentation
- Melanoma and MAPK Pathways
- Skin Protection and Aging
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Cancer and Skin Lesions
- Antenna Design and Analysis
- Allergic Rhinitis and Sensitization
- Immunotoxicology and immune responses
- Ocular Oncology and Treatments
- BRCA gene mutations in cancer
- Cancer Treatment and Pharmacology
- Indoor Air Quality and Microbial Exposure
- RNA regulation and disease
- Telomeres, Telomerase, and Senescence
Division of Cancer Epidemiology and Genetics
2019-2025
National Institutes of Health
2017-2025
National Cancer Institute
2017-2025
University of Minnesota
2022-2023
Center for Cancer Research
2023
Cancer Genetics (United States)
2020
Stanford University
2017-2019
Stanford Medicine
2018-2019
Emory University
2016
Emory University Hospital
2015
Ocular melanoma is a rare, but deadly cancer. This large cancer registry study examines the associations between solar ultraviolet radiation (UVR) and incidence of different anatomical sites ocular by sex, age, laterality, race ethnicity.
PURPOSE The purpose of this study was to develop recommendations for the diagnostic evaluation and surgical management cutaneous melanoma (CM) atypical Spitz tumors (AST) non-Spitz melanocytic (melanocytomas) in pediatric (age 0-10 years) adolescent 11-18 patients. METHODS A Children's Oncology Group–led panel with external, multidisciplinary CM specialists convened on basis available data expertise. RESULTS Thirty-three experts from multiple specialties (cutaneous/medical/surgical oncology,...
<h3>Importance</h3> Nonkeratinocyte skin cancers are an important cause of morbidity and mortality for immunosuppressed solid organ transplant recipients (SOTRs), but the spectrum disease risk factor characteristics unknown. <h3>Objective</h3> To characterize factors common rare nonkeratinocyte in SOTRs. <h3>Design, Setting, Participants</h3> This population-based cohort study included 444 497 SOTRs who underwent a US between January 1, 1987, December 31, 2017, using linked data from...
ABSTRACT Limited information is available on the clinicopathologic features and management of pediatric CRTC1::TRIM11 (CTRTs) MED15::ATF1 ‐rearranged tumors (MARTs). In this series CTRTs ( n = 5) MARTs 2), all exhibited spitzoid morphology expressed melanocytic markers. Metastatic progression occurred in one CTRT two MARTs: three received immunotherapy, resulting disease control patients death due to progressive disease. A fourth individual had lymph node micrometastasis that remained stable...
Atypical intraepidermal melanocytic proliferations (AIMP) have random cytologic atypia and other histologic features that are concerning for malignancy often require immunohistochemistry to differentiate from melanoma in situ. Immunostaining with S100, Melan-A, microphthalmia-associated transcription factor (MITF) was performed 49 morphologically well-characterized AIMP lesions. The percentage of cells the basal layer epidermis were identified as melanocytes by compared observed morphology...
Allosteric inhibitors of the tyrosine phosphatase SHP2 hold therapeutic promise in cancers with overactive RAS/ERK signaling but "adaptive resistance" to may limit benefits. Here, we utilized tumor cells that proliferate similarly or without endogenous explore means overcome this growth-independence from SHP2. We found depletion profoundly alters output vascular regulators, cytokines, chemokines, and other factors growth-resistant cancer cells. Tumors derived inoculation SHP2-depleted,...
Abstract Background Teledermatology may improve dermatologic care access in underserved areas and expand the clinical experience of dermatologists‐in‐training. The potential for teledermatology to supplement global health curricula dermatology residency education has not been explored. Methods An international virtual grand rounds ( VGR ) curriculum was created based on cases from Kabul, Afghanistan. learning objectives included understanding diagnosis management skin diseases unfamiliar...
Abstract Sebaceous carcinoma (SC) is an aggressive skin tumor. Although ultraviolet radiation (UVR) important risk factor for some cancer types, no population-level study has evaluated association between UVR and SC risk. Herein, we examined satellite-based ambient in relation to incidence using Surveillance, Epidemiology, End Results 18 registry data (2000–2016). There were 3503 microscopically confirmed cases of diagnosed during the period. For non-Hispanic whites, there was increasing...
Risk of sebaceous carcinoma (SC), a rare skin cancer associated with Muir-Torre syndrome, is elevated among solid organ transplant recipients (SOTRs). However, population studies evaluating this association and assessing survival for posttransplant cases are lacking, further understanding SC epidemiology in immunosuppressed could provide etiologic clinical insights.
Spitzoid morphology in familial melanoma has been associated with germline variants
Importance Knowledge about the prevalence and tumor types of CDKN2A -related melanoma-astrocytoma syndrome (MAS) is limited could improve disease recognition. Objective To estimate describe MAS. Design, Setting, Participants This retrospective cohort study analyzed all available MAS cases from medical centers in US (2 sites) Europe biomedical population genomic databases (UK Biobank [United Kingdom], Geisinger MyCode [US]) between January 1, 1976, December 31, 2020. Patients with germline...
Trends in the training, supply, availability, career decisions, and retirement of US dermatology physicians are not well delineated. The current study evaluates whether growth workforce will keep pace with population expansion United States. A dermatologist supply model was projected to 2030 drawing on data from American Academy Dermatology, Medical Association, Bureau Labor Statistics, Association Colleges, other associations. clinically active 2015 36 per capita (1,000,000); entry...
Abstract Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity only 13 cases reported in the literature. Histopathologically, neoplasm consists of atypical epithelioid to spindled cells that form well‐circumscribed nodule usually confined dermis and subcutis cytological features including large vesicular nuclei prominent nucleoli abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity markers. Currently, there are limited data...
Connexins (Cx) are structural proteins that form gap junctions, which vital to cell-cell communication and help regulate cell division. The purpose of this study was evaluate if there diagnostically important differences in immunostaining for connexins 43 (Cx43) 26 (Cx26) melanoma compared with nevi. Formalin-fixed paraffin-embedded sections 34 histologically well-characterized melanocytic lesions, 17 primary malignant melanomas (MM), nevi were stained a polyclonal antibody Cx43 Cx26....