A5031718687- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Connective Tissue Growth Factor Research
- Atomic and Subatomic Physics Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Gastroesophageal reflux and treatments
- Biomarkers in Disease Mechanisms
- Effects of Radiation Exposure
- Prostate Cancer Diagnosis and Treatment
- Electron Spin Resonance Studies
- AI in cancer detection
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Microscopic Colitis
- Thermal Regulation in Medicine
- Inflammatory Bowel Disease
- Fetal and Pediatric Neurological Disorders
- Gastrointestinal motility and disorders
- Cancer Cells and Metastasis
- Systemic Sclerosis and Related Diseases
Universitätsklinikum Erlangen
2020-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2025
Deutsche Forschungsgemeinschaft
2025
German Cancer Research Center
2015-2024
Heidelberg University
2015-2024
Ferioli & Gianotti (Italy)
2024
Research Institute of Radiology
2021-2022
DKFZ-ZMBH Alliance
2011-2019
Wellcome Centre for Integrative Neuroimaging
2019
University of Oxford
2019
Background Men suspected of having clinically significant prostate cancer (sPC) increasingly undergo MRI. The potential deep learning to provide diagnostic support for human interpretation requires further evaluation. Purpose To compare the performance clinical assessment a system optimized segmentation trained with T2-weighted and diffusion MRI in task detection lesions suspicious sPC. Materials Methods In this retrospective study, sequences from consecutive men examined single 3.0-T...
To assess the value of iterative frequency split-normalized (IFS) metal artifact reduction (MAR) for computed tomography (CT) hip prostheses.This study had institutional review board and local ethics committee approval. First, a phantom with steel titanium prostheses that inlays water, fat, contrast media in pelvis was used to optimize IFS algorithm. Second, 41 consecutive patients who were undergoing CT included. Data sets reconstructed filtered back projection, algorithm, linear...
Radiotherapy is a mainstay for the treatment of lung cancer that can induce pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (CTGF) central mediator remodeling. A radiation-induced mouse model fibrosis was used to determine if transient administration human antibody CTGF (FG-3019) started at different times before after 20 Gy thoracic irradiation reduced acute and chronic radiation toxicity. Mice (25 mice/group; 10 mice/group in confirmation study)...
Radiotherapy is used for the treatment of lung cancer, but at same time induces acute pneumonitis and subsequent pulmonary fibrosis, where TGF-β signaling considered to play an important role.We irradiated thoraces C57BL/6 mice (single dose, 20 Gy) administered them a novel small-molecule receptor I serine/threonine kinase inhibitor (LY2109761) orally 4 weeks before, during, or after radiation. Noninvasive imaging including volume computed tomography (VCT) MRI was conducted 6, 16,...
Early identification of prognostic superior characteristics in glioma patients such as isocitrate dehydrogenase (IDH) mutation and O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is great clinical importance. The study purpose was to investigate the non-invasive predictability IDH status, MGMT methylation, differentiation low-grade versus high-grade (LGG vs HGG) newly diagnosed employing relaxation-compensated multipool chemical exchange saturation transfer (CEST)...
Purpose To assess radiomics as a tool to determine how well lesions found suspicious on breast cancer screening X‐ray mammography can be categorized into malignant and benign with unenhanced magnetic resonance (MR) diffusion‐weighted imaging T 2 ‐weighted sequences. Materials Methods From an asymptomatic cohort, 50 women mammographically findings were examined contrast‐enhanced MRI (ceMRI) at 1.5T. Out of this protocol unenhanced, abbreviated (ueMRI) including ‐weighted, ( w), (DWI), DWI...
To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic on contrast enhanced T1-weighted MRI scans (cT1).In 37 patients newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 position the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as (CE), (NE) or (NEC) tissue samples "viable tumor cells", "blood" "necrotic (with without...
To evaluate the ability of a diagnostic abbreviated magnetic resonance (MR) imaging protocol consisting maximum intensity projections (MIPs) from diffusion-weighted with background suppression (DWIBS) and unenhanced morphologic sequences to help predict likelihood malignancy on suspicious screening x-ray mammograms, as compared an contrast material-enhanced MR full breast protocol.This prospective institutional review board-approved study included 50 women (mean age, 57.1 years; range, 50-69...
The "glymphatic system" (GS), a brain-wide network of cerebrospinal fluid microcirculation, supplies pathway through and out the central nervous system (CNS); malfunction is implicated in variety neurological disorders. In this exploratory study, we analyzed potential new imaging approach that coined delayed T2-weighted gadolinium-enhanced to visualize GS vivo.Heavily fluid-attenuated inversion recovery (hT2w-FLAIR) magnetic resonance was obtained before, 3 hours 24 after intravenous...
Purpose To evaluate a radiomics model of Breast Imaging Reporting and Data System (BI-RADS) 4 5 breast lesions extracted from breast-tissue-optimized kurtosis magnetic resonance (MR) imaging for lesion characterization by using sensitivity threshold similar to that biopsy. Materials Methods This institutional study included 222 women at two independent sites (site 1: training set 95 patients; mean age ± standard deviation, 58.6 years 6.6; 61 malignant 34 benign lesions; site 2: test 127 age,...
Background Long COVID occurs at a lower frequency in children and adolescents than adults. Morphologic free-breathing phase-resolved functional low-field-strength MRI may help identify persistent pulmonary manifestations after SARS-CoV-2 infection. Purpose To characterize both morphologic changes of lung parenchyma with post–COVID-19 condition compared healthy controls. Materials Methods Between August December 2021, cross-sectional clinical trial using was performed from single academic...
Purpose Chemical exchange sensitive spin‐lock and related techniques allow to observe the uptake of administered D‐glucose in vivo. The exchange‐weighting increases with magnetic field strength, but inhomogeneities radiofrequency (RF) at ultrahigh whole‐body scanners lead artifacts conventional experiments. Thus, our aim was development an adiabatically prepared T 1ρ ‐based imaging sequence applicable studies glucose metabolism tumor patients strengths. Methods An on‐resonant approach...
Purpose To evaluate the ability to detect intracerebral regions of increased glucose concentration at T1ρ-weighted dynamic glucose-enhanced (DGE) magnetic resonance (MR) imaging 7.0 T. Materials and Methods This prospective study was approved by institutional review board. Nine patients with newly diagnosed glioblastoma four healthy volunteers were included in this from October 2015 July 2016. Adiabatically prepared chemical exchange-sensitive spin-lock performed a 7.0-T whole-body unit...
Purpose To determine the effect of at least five serial injections macrocyclic gadolinium-based contrast agent (GBCA) gadoterate meglumine on signal intensity (SI) dentate nucleus (DN) pediatric brain nonenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 41 patients (age range, 3-17 years) who were imaged in consecutive 1.5-T MR examinations with exclusive use (plus a final additional imaging...
Background: Radiotherapy (RT) is a mainstay for the treatment of lung cancer, but effective dose often limited by development radiation-induced pneumonitis and pulmonary fibrosis. Transforming growth factor β (TGFβ) platelet-derived (PDGF) play crucial roles in these diseases, effects dual inhibition on fibrosis remain unclear. Methods: C57BL/6 mice were treated with 20 Gy to thorax induce PDGF receptor inhibitors SU9518 SU14816 (imatinib) TGFβ inhibitor galunisertib applied individually or...
Abstract Background To evaluate the correlation between levels of C‐reactive protein ( CRP ), calprotectin, and small bowel motility in patients with Crohn's disease assessed MRI . Methods This prospective institutional review board approved study included magnetic resonance imaging enterography MRE ) analyses inflammatory markers blood (C‐reactive protein) feces (calprotectin). For cine , a coronal 2D‐T2w sequence was used on 1.5 T system. Small analyzed 13 using dedicated MR ‐motility...
// Sebastian Regnery 1, 2 , Adeberg 3 Constantin Dreher Johanna Oberhollenzer Jan-Eric Meissner 4 Steffen Goerke Johannes Windschuh Katerina Deike-Hofmann Bickelhaupt Moritz Zaiss 5 Alexander Radbruch Martin Bendszus 6 Wolfgang Wick 7 Andreas Unterberg 8 Stefan Rieken 1 Jürgen Debus Peter Bachert Mark Ladd 4, 9, 10 Heinz-Peter Schlemmer and Daniel Paech Department of Radiation Oncology, University Hospital Heidelberg, Germany German Cancer Research Center (DKFZ), Division Radiology, HIRO...
To evaluate whether neural networks can distinguish between seropositive RA, seronegative and PsA based on inflammatory patterns from hand MRIs to test how psoriasis patients with subclinical inflammation fit into such patterns.ResNet were utilized compare RA vs PsA, respect MRI data. Results T1 coronal, T2 coronal axial fat-suppressed contrast-enhanced (CE), sequences used. The performance of trained was analysed by the area under receiver operating characteristics curve (AUROC) without...
With the COVID-19 pandemic, repetitive lung examinations have become necessary to follow-up symptoms and associated alterations. Low-field MRI, benefiting from reduced susceptibility effects, is a promising alternative for imaging limit radiations absorbed by patients during CT examinations, which also limited capability assess functional The aim of this investigative study was explore abnormalities that free-breathing 0.55 T MRI in combination with phase-resolved (PREFUL) analysis could...
Abstract Background The objective of the study was to correlate MR ‐detectable motility alterations terminal ileum with biopsy‐documented active and chronic changes in Crohn's disease. Methods This IRB approved retrospective analysis 43 patients included magnetic resonance enterography ( MRE ) biopsies (<2 weeks apart). Motility measured at using coronal 2D true FISP pulse sequences (1.5T MRI , TR 83.8, TE 1.89) dedicated assessment software. grading (hypermotility, normal, hypomotility,...
The task of localizing and categorizing objects in medical images often remains formulated as a semantic segmentation problem. This approach, however, only indirectly solves the coarse localization by predicting pixel-level scores, requiring ad-hoc heuristics when mapping back to object-level scores. State-of-the-art object detectors on other hand, allow for individual scoring an end-to-end fashion, while ironically trading ability exploit full pixel-wise supervision signal. can be...