A5015618093- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Meat and Animal Product Quality
- Reproductive Physiology in Livestock
- Trypanosoma species research and implications
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Genetic diversity and population structure
- Evolution and Genetic Dynamics
- Effects of Environmental Stressors on Livestock
- Animal Genetics and Reproduction
- Insect Resistance and Genetics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Circular RNAs in diseases
- Wheat and Barley Genetics and Pathology
- Health and Wellbeing Research
- Milk Quality and Mastitis in Dairy Cows
- Single-cell and spatial transcriptomics
- Dengue and Mosquito Control Research
- Gout, Hyperuricemia, Uric Acid
- Animal Ecology and Behavior Studies
- Congenital heart defects research
Yale University
2018-2025
Livestock Improvement Corporation
2014-2023
Dana-Farber Brigham Cancer Center
2021-2023
Brigham and Women's Hospital
2021-2023
Harvard University
2021-2023
Dana-Farber Cancer Institute
2021-2023
Statens Serum Institut
2003
University of Lagos
2001
Abstract Lactation, hair development and homeothermy are characteristic evolutionary features that define mammals from other vertebrate species. Here we describe the discovery of two autosomal dominant mutations with antagonistic, pleiotropic effects on all three these biological processes, mediated through prolactin signalling pathway. Most conspicuously, in ( PRL) its receptor (PRLR) have an impact thermoregulation morphology phenotypes, giving prominence to this pathway outside classical...
Abstract The mammary gland is a prolific lipogenic organ, synthesising copious amounts of triglycerides for secretion into milk. fat content milk varies widely both between and within species recent independent genome-wide association studies have highlighted percentage quantitative trait locus (QTL) large effect on bovine chromosome 5. Although EPS8 MGST1 been proposed to underlie these signals, the causative status genes has not functionally confirmed. To investigate this QTL in detail, we...
Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk most species. Bovine lactose also a key component of many human food products. However, compared to analyses other components, genetic control has been little studied. Here we present first GWAS focussed on analysis traits. Using discovery population 12,000 taurine dairy cattle, detail 27 QTL concentration yield, subsequently validate effects 26 these loci distinct 18,000 cows. We next...
Abstract A major pleiotropic quantitative trait locus (QTL) located at ~25 Mbp on bovine chromosome 14 affects a myriad of growth and developmental traits in Bos taurus indicus breeds. These QTL have been attributed to two functional variants the bidirectional promoter PLAG1 CHCHD7 . Although is good candidate for mediating these effects, its role remains uncertain given that are also associated with expression five additional genes broader locus. In current study, we conducted (eQTL)...
Tsetse flies (Glossina spp.) are vectors of parasitic trypanosomes, which cause human (HAT) and animal African trypanosomiasis (AAT) in sub-Saharan Africa. In Uganda, Glossina fuscipes (Gff) is the main vector HAT, where it transmits Gambiense disease northwest Rhodesiense central, southeast western regions. Endosymbionts can influence transmission efficiency parasites through their insect via conferring a protective effect against parasite. It known that bacterium Spiroplasma capable...
White spotting of the coat is a characteristic trait various domestic species including cattle and other mammals. It hallmark Holstein-Friesian cattle, several previous studies have detected genetic loci with major effects for white in animals ancestry. Here, our aim was to better understand underlying molecular mechanisms spotting, by conducting largest mapping study this date.Using imputed whole-genome sequence data, we conducted genome-wide association analysis 2973 mixed-breed cows...
Abstract Background Fourier-transform mid-infrared (FT-MIR) spectroscopy provides a high-throughput and inexpensive method for predicting milk composition other novel traits from samples. While there have been many genome-wide association studies (GWAS) conducted on FT-MIR predicted traits, few GWAS individual wavenumbers. Using imputed whole-genome sequence 38,085 mixed-breed New Zealand dairy cattle, we 895 wavenumber phenotypes, assessed the value of these direct phenotypes identifying...
Fourier-transform mid-infrared (FT-MIR) spectroscopy is a high-throughput and inexpensive methodology used to evaluate concentrations of fat protein in dairy cattle milk samples. The objective this study was compare the genetic characteristics FT-MIR predicted fatty acids individual proteins with those that had been measured directly using gas liquid chromatography methods. data based on 2,005 samples collected from 706 Holstein-Friesian × Jersey animals were managed seasonal, pasture-based...
The Asian tiger mosquito, Aedes albopictus, is currently the most widespread invasive mosquito species in world. It poses a significant threat to human health, as it vector for several arboviruses. We used SNP chip genotype 748 Ae. albopictus mosquitoes from 41 localities across Europe, 28 native range Asia, and 4 Americas. Using multiple algorithms, we examined population genetic structure differentiation within Europe our global dataset gain insight into origin of European populations....
Over many years, artificial selection has substantially improved milk production by cows. However, the genes that underlie quantitative trait loci (QTL) remain relatively poorly characterised. Here, we investigate a previously reported QTL located at CSF2RB locus on chromosome 5, for several phenotypes, to better understand its underlying genetic and molecular causes. Using population of 29,350 taurine dairy cows, conducted association analyses yield composition traits, identified highly...
Abstract Background The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic quantitative trait locus (QTL) with large influence on milk composition phenotypes. Since first described over 15 years ago, protein-coding variant K232A has been assumed as causative underlying these effects, following in-vitro studies that demonstrated differing levels of synthesis between two protein isoforms....
Abstract Background Deleterious recessive conditions have been primarily studied in the context of Mendelian diseases. Recently, several deleterious mutations with large effects were discovered via non-additive genome-wide association studies (GWAS) quantitative growth and developmental traits cattle, which showed that can be used as proxies genetic disorders when such are indicative whole-animal health status. We reasoned lactation cattle might also reflect disorders, given increased energy...
Understanding the mechanisms that enforce, maintain or reverse process of speciation is an important challenge in evolutionary biology. This study investigates patterns divergence and discusses processes form divergent lineages tsetse fly Glossina fuscipes Uganda. We sampled 251 flies from 18 sites spanning known genetic four admixture zones between them. apply population genomics, hybrid zone approximate Bayesian computation to analysis three types markers: 55,267 double-digest restriction...
In order to examine a sensitive unbiased consensus PCR with routine sequencing for HPV typing, we analysed Danish male and female patients suspected of having an infection. We used the well‐characterised nested setting MY09/MY11 GP5+/GP6+ primers, followed by cycle sequencing. Of 1,283 clinical samples from based on infection, found 379 (29%) negatives 894 (70%) positives. Samples containing >5000 copies/ml were genotyped 552 women >15 years age, 398 characterised as high‐risk types...
Glossina pallidipes is the main vector of animal African trypanosomiasis and a potential human in eastern Africa where it poses large economic burden public health threat. Vector control efforts have succeeded reducing infection rates, but recent resurgence tsetse fly population density raises concerns that programs require improved strategic planning over larger geographic temporal scales. Detailed knowledge structure dispersal patterns can provide required information to improve planning....