A5110906316- Sarcoidosis and Beryllium Toxicity Research
- Bacillus and Francisella bacterial research
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Sinusitis and nasal conditions
- Ultrasound in Clinical Applications
- Trace Elements in Health
- Respiratory Support and Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Bacterial biofilms and quorum sensing
- Constraint Satisfaction and Optimization
- Hemodynamic Monitoring and Therapy
- Pulmonary Hypertension Research and Treatments
- Video Analysis and Summarization
- Bacteriophages and microbial interactions
- Systemic Sclerosis and Related Diseases
- Multimodal Machine Learning Applications
- Sepsis Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infectious Diseases and Tuberculosis
Beijing Children’s Hospital
2024-2025
Capital Medical University
2024-2025
Baoding People's Hospital
2025
Tongji University
2013-2024
Shanghai Pulmonary Hospital
2015-2022
To explore if chest high-resolution computed tomography (HRCT) can make higher accurate stages for thoracic sarcoidosis stage than X-ray (CRX) only.Clinical data from medical records of consecutive patients with a confirmed diagnosis pulmonary at Shanghai Pulmonary Hospital January 1 2012 to December 31 2016 and treated the Sarcoidosis Center University Cincinnati Medical Center, Ohio, USA 2010 2015 were reviewed. The clinical 227 diagnosed (140 Chinese 87 American) Their was determined by...
This study aims to use high throughput 16SrRNA gene sequencing examine the bacterial profile of lymph node biopsy samples patients with sarcoidosis and further verify association between Propionibacterium acnes (P. acnes) sarcoidosis. A total 36 mediastinal specimens were collected from 17 cases sarcoidosis, 8 tuberculosis (TB group), 11 non-infectious lung diseases (control group). The V4 region in was amplified sequenced using platform MiSeq, established. data analysis software QIIME...
This study aims to investigate the predictive effectiveness of bedside lung ultrasound score (LUS) in conjunction with rapid shallow breathing index (RSBI) and oxygenation (P/F ratio) for weaning pediatric patients from mechanical ventilation. was a retrospective study. Eighty-two critically ill patients, who were admitted Pediatric Intensive Care Unit (PICU) underwent ventilation January 2023 April 2024, enrolled this Prior weaning, all LUS, concurrent measurements their RSBI P/F ratio....
Abstract Background The diagnosis of sarcoidosis is still a significant challenge in China because the need to exclude other diseases including granulomatous infections and malignancies that may be clinically radiographically similar. specific aim study search for serum protein biomarkers validate their clinical usefulness differential diagnosis. Methods Serum samples were collected from patients with (n = 37), compared those tuberculosis 20), pulmonary healthy volunteers 20) determination...
As a pivotal branch of intelligent human-computer interaction, visual dialog is technically challenging task that requires artificial intelligence (AI) agents to answer consecutive questions based on image content and history dialog. Despite considerable progresses, still suffers from two major problems: (1) how design flexible cross-modal interaction patterns instead over-reliance expert experience (2) infer underlying semantic dependencies between dialogues effectively. To address these...
Background In this study, we sought to identify differentially expressed proteins in the serum of patients with sarcoidosis or tuberculosis and evaluate these as markers for differential diagnosis sputum-negative tuberculosis. Methods Using protein microarrays, identified 3 exhibiting expression between Elevated was verified using enzyme-linked immunosorbent assay (ELISA) further confirmed by immunohistochemistry. Receiver operating characteristic (ROC) curve, logistic regression analysis,...
Abstract: Lung-targeting drugs are thought to be potential therapies of refractory lung diseases by maximizing local drug concentrations in the avoid systemic circulation. However, a major limitation developing lung-targeted is acquirement lung-specific ligands. Pulmonary surfactant protein A (SPA) predominantly synthesized type II alveolar epithelial cells, and may serve as lung-targeting ligand. Here, we generated recombinant rat pulmonary SPA (rSPA) an antigen immunized alpaca produce two...
Abstract Nanobody (Nb) is a promising vector for targeted drug delivery. This study aims to identify an Nb that can specifically target the lung by binding human pulmonary surfactant protein A (SP-A). Human frozen tissue sections were used 3 rounds of biospanning our previously constructed library rat SP-A establish sub-library Nb, which bound tissues. Phage-ELISA was performed screen Nb4, SP-A. The affinity Kd Nb4 recombinant 7.48 × 10 −7 M. (19 kDa) stable at 30 °C–37 °C and pH 7.0–7.6 in...
<title>Abstract</title> <bold>Objective:</bold>This study aims to investigate the predictive effectiveness of bedside lung ultrasound score (LUS) in conjunction with rapid shallow breathing index (RSBI) and oxygenation (P/F ratio) for weaning pediatric patients from mechanical ventilation. <bold>Methods: </bold>This was a retrospective study. Eighty-two critically ill patients, who were admitted Pediatric Intensive Care Unit (PICU) underwent ventilation January 2023 April 2024, enrolled this...