A5067088439- Fuel Cells and Related Materials
- RNA Interference and Gene Delivery
- nanoparticles nucleation surface interactions
- Membrane-based Ion Separation Techniques
- Glycosylation and Glycoproteins Research
- Advanced Chemical Physics Studies
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Spectroscopy and Quantum Chemical Studies
- Extracellular vesicles in disease
- Hydrogels: synthesis, properties, applications
- Advanced Thermodynamics and Statistical Mechanics
- Ion-surface interactions and analysis
- Advanced Battery Materials and Technologies
- Semiconductor materials and devices
- Membrane Separation and Gas Transport
- Underwater Vehicles and Communication Systems
- Graphene research and applications
- Nanopore and Nanochannel Transport Studies
- Advanced Drug Delivery Systems
- Underwater Acoustics Research
- Electrocatalysts for Energy Conversion
- Quantum chaos and dynamical systems
- Bacterial Infections and Vaccines
- Analytical Chemistry and Sensors
Tokyo Institute of Technology
2025
Setsunan University
2022-2025
Kyoto University
2015-2024
National Institutes for Quantum Science and Technology
2016-2024
Chiba University
2023-2024
Kyoto Katsura Hospital
2013-2023
Takasaki Advanced Radiation Research Institute
2022-2023
Kwansei Gakuin University
2001-2022
High Energy Accelerator Research Organization
2022
Graduate School USA
2014-2020
On the basis of realistic tight-binding band-structure calculations, we predict that carbon microtubules exhibit striking variations in electronic transport, from metallic to semiconducting with narrow and moderate band gaps, depending on diameter tubule degree helical arrangement hexagons. The origin this drastic variation structure is explained terms two-dimensional graphite.
Abstract Exosomes are a valuable biomaterial for the development of novel nanocarriers as functionally advanced drug delivery systems. To control and modify performance exosomal nanocarriers, we developed hybrid exosomes by fusing their membranes with liposomes using freeze–thaw method. embedded specific membrane protein isolated from genetically modified cells were fused various liposomes, confirming that engineering methods can be combined genetic modification techniques. Cellular uptake...
We develop methodology for performing time dependent quantum mechanical calculations by representing the wave function as a sum of Gaussian packets (GWP) each characterized set parameters such width, position, momentum, and phase. The problem computing evolution is thus reduced to that finding in Gaussians. This parameter motion determined minimizing error made replacing exact Schrödinger equation with its representation approximant. leads first order differential equations dependence...
ABSTRACT To establish a safer and more effective vaccine against pneumococcal respiratory infections, current knowledge regarding the antigens common among strains improvements to system for delivering these across mucosal barrier must be integrated. We developed that combines advantages of surface protein A (PspA) with nontoxic intranasal delivery based on nanometer-sized hydrogel (nanogel) consisting cationic cholesteryl group-bearing pullulan (cCHP). The efficacy nanogel-based PspA nasal...
Because existing therapeutic cancer vaccines provide only a limited clinical benefit, different vaccination strategy is necessary to improve vaccine efficacy. We developed nanoparticulate by encapsulating synthetic long peptide antigen within an immunologically inert hydrogel (nanogel) of cholesteryl pullulan (CHP). After subcutaneous injection mice, the nanogel-based was efficiently transported draining lymph node, and preferentially engulfed medullary macrophages but not sensed other...
Abstract CagA, encoded by cytotoxin-associated gene A ( cagA ), is a major virulence factor of Helicobacter pylori , gastric pathogen involved in the development upper gastrointestinal diseases. Infection with -positive H. may also be associated diseases outside stomach, although mechanisms through which infection promotes extragastric remain unknown. Here, we report that CagA present serum-derived extracellular vesicles, known as exosomes, patients infected (n = 4). We found epithelial...
The formation of fibrils by amyloid β‐protein (Aβ) is considered as a key step in the pathology Alzheimer's disease (AD). Inhibiting aggregation Aβ promising approach for AD therapy. In this study, we used biocompatible nanogels composed polysaccharide pullulan backbone with hydrophobic cholesterol moieties (cholesterol‐bearing pullulan, CHP) artificial chaperones to inhibit Aβ‐(1–42) marked amyloidgenic activity and cytotoxicity. CHP‐nanogels incorporated up 6–8 molecules per particle...
This article is concerned with the time dependent quantum theory of collision heavy particles that result in excitation internal degrees freedom, such as electronic excitations or charge transfer. Attempts to treat motion particle classically encounter difficulties typical all problems which classical freedom are strongly coupled freedom: They lack a feedback mechanism will force degree respond companion. To avoid we propose method nuclear wave function associated each state represented by...
We discuss electronic energy and charge-transfer processes at surfaces in terms of curve-crossing models. suggest that low kinetic energies the trajectory approximation should be replaced by a mean-trajectory (MTA), which nuclear motion gets feedback from adjusts to dynamics. two derivations MTA using an eikonal path-integral method. The effects phonon or electron-hole pair excitations on process are also incorporated.
Enzymatically synthesized glycogen (ESG), a highly branched (1→4)(1→6)-linked α-glucan, is new monodisperse spherical hyperbranched nanoparticle (molecular weight, 106−107; diameter, 20−30 nm), polysaccharide nanoball. Amphiphilic ESG nanoballs were by introducing cholesterol group to enzymatically (CHESG). CHESG assembled into structure containing few molecules form cluster nanogels (approximately 35 nm in diameter) water. The dissociated the addition of cyclodextrin (CD) supramolecular...
Pressure-sensitive adhesive powder shows no adhesion in its original form and nature after application of shear stress.
Surface polymer engineering was applied with a carrier of exosomes, namely, the amphiphilic cationic CHP (cCHP) nanogel, to improve delivery exosome content by forming complexes exosomes.
Current polysaccharide-based pneumococcal vaccines are effective but not compatible with all serotypes of Streptococcus pneumoniae. We previously developed an adjuvant-free cationic nanogel nasal vaccine containing surface protein A (PspA), which is expressed on the surfaces serotypes. Here, to address sequence diversity PspA proteins, we formulated a nanogel-based trivalent and demonstrated vaccine's immunogenicity protective efficacy in macaques by using newly spray device applicable...
We study the case in which nonlinear Schrödinger equation (NLSE) on simple networks consisting of vertices and bonds has an infinite number constants motion becomes completely integrable just as a one-dimensional (1D) chain. Here strength cubic nonlinearity is different from bond to bond, are assumed have at least two semi-infinite with one them working incoming bond. The connection formula obtained norm energy conservation rules shows (1) solution each part universal (bond-independent)...
The effects of self-assembled polysaccharide nanogels on colloidal and thermal stability lipase from Pseudomonas cepacia were investigated. enzyme activity, especially k(cat), drastically increased in the presence cholesterol-bearing pullulan (CHP). thermostability complex because denaturation temperature by more than 20 degrees C complexation with CHP nanogels. Lipase aggregation upon heating was effectively prevented Moreover, protected lyophilization-induced aggregation....
A nanocarrier-integrated bottom-up method is a promising strategy for advanced drug-release systems. Self-assembled nanogels, which are one of the most beneficial nanocarriers drug-delivery systems, tectonically integrated to prepare nanogel-crosslinked (NanoClik) microspheres. NanoClik microspheres consisting nanogel-derived structures (observed by STED microscopy) release "drug-loaded nanogels" after hydrolysis, resulting in successful sustained drug delivery vivo. As service our authors...
RNAi enables potent and specific gene silencing, potentially offering useful means for treatment of cancers. However, safe efficient drug delivery systems (DDS) that are appropriate intra-tumor siRNA or shRNA have rarely been established, hindering clinical application technology to cancer therapy. We devised hydrogel polymer nanoparticles, nanogel, shown its validity as a novel DDS various molecules. Here we examined the potential self-assembled nanogel cholesterol-bearing cycloamylose with...
Abstract Protein pharmaceuticals show great therapeutic promise, but effective intracellular delivery remains challenging. To address the need for efficient protein transduction systems, we used a magnetic nanogel chaperone (MC): hybrid of polysaccharide nanogel, carrier with molecular chaperone‐like properties, and iron oxide nanoparticles, enabling magnetically guided delivery. The MC complexed model proteins, such as BSA insulin, was not cytotoxic. Cargo proteins were delivered to target...