A5040415408- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Liver Disease and Transplantation
- Full-Duplex Wireless Communications
- Neuroscience and Neural Engineering
- RNA Interference and Gene Delivery
- Ion Channels and Receptors
- Inflammatory Myopathies and Dermatomyositis
- Ion channel regulation and function
- Genetic and Kidney Cyst Diseases
- Parvovirus B19 Infection Studies
- Immune Response and Inflammation
- Antenna Design and Analysis
- T-cell and Retrovirus Studies
- Extracellular vesicles in disease
- Hematopoietic Stem Cell Transplantation
- Biomedical Research and Pathophysiology
Université Paris-Saclay
2020-2025
Institut Gustave Roussy
2021-2025
Assistance Publique – Hôpitaux de Paris
2025
Inserm
2010-2024
Laboratoire d’immunologie intégrative du cancer
2023
Immunologie intégrative des tumeurs et immunothérapie du cancer
2022
Hypertension pulmonaire : physiopathologie et innovation thérapeutique
2020
Université Paris-Sud
2018
Université de Tours
2010-2016
Hôpital Paul-Brousse
2016
Mesenchymal stem cells (MSCs) are powerful immunomodulators that regulate the diverse functions of immune involved in allogeneic reactions, such as T and natural killer (NK) cells, through cell-cell contact or secreted factors. Exosomes by MSCs may be their regulatory functions, providing new therapeutic tools. Here, we showed fetal liver (FL) MSC-derived exosomes inhibit proliferation, activation, cytotoxicity NK cells. bearing latency associated peptide (LAP), TGFβ, thrombospondin 1...
Abstract Human dendritic cells (hDCs) produce IL-2 and express IL-2R α-chain (CD25), but the role of in DC functions is not well defined. A recent study suggested that main function CD25 on hDCs was to transpresent activate T lymphocytes. Our results demonstrate expression three chains induces STAT5 phosphorylation. Interestingly, use inhibitors p-STAT5 revealed increases LPS-induced IFN-γ through Finally, we report ability helpless CD8+ cells, most likely because IL-2–triggered synthesis,...
Introduction Focal and Segmental GlomeruloSclerosis (FSGS) can cause nephrotic syndrome with a risk of progression to end-stage renal disease. The idiopathic form has high rate recurrence after transplantation, suggesting the presence systemic circulating factor that causes glomerular permeability be removed by plasmapheresis or protein-A immunoadsorption. Results To identify this factor, eluate proteins bound on therapeutic immunoadsorption columns were analyzed comparative electrophoresis...
Abstract Accumulating evidence suggests that CD4 help is needed at the memory stage to mount effective secondary CD8 T cell responses. In this paper, we report cells can provide efficient after interaction of two lymphocytes with distinct dendritic cells. Provision required direct cell–cell contact and involved both IL-2 CD40 ligation, within a CD4–CD8 synapse. Thus, following antigenic APCs, activated appear separate from their respective APCs before meeting each other for provision,...
BK polyomavirus-associated nephropathy (BKPyVAN) is a significant complication in kidney transplant recipients (KTRs), associated with higher level of plasmatic polyomavirus (BKPyV) replication and leading to poor graft survival.
Introduction: Focal and segmental glomerulosclerosis (FSGS) is a frequent form of glomerulonephritis that may be caused by soluble permeability factor regulated the immune system. We previously describeda calcium/calmodulin-dependent serine/threonine kinase (CASK)acting as in patients with recurrent FSGS (rFSGS). Here, we aimed to identify cells associated CASK secretion rFSGS. Methods: FACS, western blotting immunoprecipitation were performed detect peripheral blood mononuclear cells,...
B cells play a major role in the antibody-mediated rejection (AMR) of solid organ transplants, public health concern. The germinal center (GC) is involved generation donor-specific antibody-producing plasma and memory cells, which are often poorly controlled by current treatments. Myeloid cell leukemia-1 (Mcl-1), an anti-apoptotic member B-cell lymphoma-2 (Bcl-2) family, essential for maintenance GC reaction differentiation. During chronic AMR, tertiary lymphoid structures (TLS) resembling...
Abstract Regulatory T cells (Treg) play a crucial role in controlling immunity and transplant rejection. Two main groups of Treg have been described: antigen-induced (iTreg) natural (nTreg). The ways to induce the mechanisms action subsets remained ill defined, particularly for their effects on CD8+ cells. are major agents rejection allografts; aim this study is investigate exerted by human CD4+ iTreg induced mycophenolic acid-treated dendritic suppress proliferation allogeneic cell–cell...
Calcineurin inhibitors have improved graft survival in solid-organ transplantation but their use is limited by toxicity, requiring a switch to another immunosuppressor some cases. Belatacept one option that has been shown improve and patient despite being associated with higher risk of acute cellular rejection. This rejection correlated the presence belatacept-resistant T cells. We performed transcriptomic analysis vitro-activated cells identify pathways affected belatacept...
Belatacept was developed to replace calcineurin inhibitors in kidney transplantation. Its use is associated with better transplant function, a lower incidence of anti-donor antibodies and higher graft survival. However, it also risk cellular rejection. We studied the activation proliferation mechanisms belatacept-resistant T lymphocytes (TLs), identify new pathways for control. performed transcriptomic analysis on CD4+ CD57+ PD1- memory TLs, which are responsible rejection, after allogeneic...
Acute rejection rate is low after simultaneous liver-kidney transplantation (SLKT), leading some groups to minimize immunosuppressive (IS) regimens. However, the impact of preformed (pDSA) or de novo donor-specific antibodies (dnDSA) on graft remains unclear.We performed a retrospective analysis 102 consecutive SLKT patients study anti-HLA antibodies.Anti-HLA were detected in 75 recipients (class I 23.8%, both classes and II class 14.3%). In total, 42.8% had pDSA 21.7% developed dnDSA....
Abstract BK-virus-associated nephropathy (BKvAN) is a major complication in kidney transplant recipients, associated with higher level of BK-virus (BKv) replication and leading to poor graft survival. In large cohort recipients various BKv reactivation levels, we found that BKvAN was low BKv-specific memory CD8 T-cell functionality an exhausted-like phenotype. This severe lymphocyte impairment class II HLA mismatches. vitro experiments showed allogeneic CD4 T cells partly restored responses....