A5102903256- Fungal and yeast genetics research
- Genomics and Chromatin Dynamics
- Plant Gene Expression Analysis
- Plant Reproductive Biology
- Plant-Microbe Interactions and Immunity
Trinity College Dublin
2023-2024
The Tup1-Cyc8 complex in Saccharomyces cerevisiae was one of the first global co-repressors gene transcription discovered. However, despite years study, a full understanding contribution Tup1p and Cyc8p to function is lacking. We examined TUP1 CYC8 single double deletion mutants show that represses more genes than , there are subject (i) unique repression by or (ii) redundant (iii) at which de-repression cyc8 mutant dependent upon vice-versa. also reveal can make distinct contributions...
The transcriptome from a Saccharomyces cerevisiae tup1 deletion mutant was one of the first comprehensive yeast transcriptomes published. Subsequent and cyc8 mutants firmly established Tup1-Cyc8 complex as predominantly acting repressor gene transcription. However, tup1/cyc8 or conditional would all have been influenced by striking flocculation phenotypes that these display. In this study, we separated impact in to reveal those genes (i) subject solely Cyc8p-dependent regulation, (ii)...