Wolfgang Vorbrüggen

ORCID: 0000-0003-1076-5560
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Research Areas
  • Rheumatoid Arthritis Research and Therapies
  • Autoimmune and Inflammatory Disorders Research
  • Spondyloarthritis Studies and Treatments
  • Systemic Lupus Erythematosus Research
  • Musculoskeletal Disorders and Rehabilitation
  • Psoriasis: Treatment and Pathogenesis
  • Forest Ecology and Biodiversity Studies
  • Entomological Studies and Ecology
  • Chronic Lymphocytic Leukemia Research
  • Social Media in Health Education
  • Health and Medical Studies
  • Immunodeficiency and Autoimmune Disorders
  • Forest Insect Ecology and Management
  • Chronic Disease Management Strategies
  • Lymphoma Diagnosis and Treatment
  • Healthcare Systems and Technology
  • Clinical Reasoning and Diagnostic Skills
  • COVID-19 and Mental Health
  • Biosimilars and Bioanalytical Methods
  • Long-Term Effects of COVID-19
  • Cytokine Signaling Pathways and Interactions
  • Systemic Sclerosis and Related Diseases
  • Medical Coding and Health Information

Urologische Klinik München
2023

Abstract Background Timely diagnosis and treatment are essential in the effective management of inflammatory rheumatic diseases (IRDs). Symptom checkers (SCs) promise to accelerate diagnosis, reduce misdiagnoses, guide patients more effectively through health care system. Although SCs increasingly used, there exists little supporting evidence. Objective To assess diagnostic accuracy, patient-perceived usability, acceptance two SCs: (1) Ada (2) Rheport. Methods Patients newly presenting a...

10.1186/s13075-021-02498-8 article EN cc-by Arthritis Research & Therapy 2021-04-13

Introduction An increasing number of digital tools, including dedicated diagnostic decision support systems (DDSS) exist to better assess new symptoms and understand when where seek medical care. The aim this study was evaluate patient's previous online assessment experiences compare the acceptability, usability, usefulness potential impact artificial intelligence (AI)-based symptom checker (Ada) an questionnaire-based self-referral tool (Rheport). Materials Methods Patients newly presenting...

10.3389/fpubh.2022.844669 article EN cc-by Frontiers in Public Health 2022-02-22

Objective Treatment options with disease-modifying antirheumatic drugs (DMARDs) for psoriatic arthritis (PsA) have evolved over recent years. In addition to Janus kinase inhibitors (JAKi), four classes of biologic DMARDs (bDMARDs; interleukin [IL]-23 [IL-23i], IL-12/23 [IL-12/23i], tumor necrosis factor [TNFi], and IL-17 [IL-17i]) are currently approved moderate severe PsA treatment. There is minimal evidence the persistence these among outpatients in a real-world scenario during period...

10.3389/fimmu.2024.1395968 article EN cc-by Frontiers in Immunology 2024-05-23

Background The diagnosis of inflammatory rheumatic diseases (IRDs) is often delayed due to unspecific symptoms and a shortage rheumatologists. Digital diagnostic decision support systems (DDSSs) have the potential expedite help patients navigate health care system more efficiently. Objective aim this study was assess accuracy mobile artificial intelligence (AI)–based symptom checker (Ada) web-based self-referral tool (Rheport) regarding IRDs. Methods A prospective, multicenter, open-label,...

10.2196/55542 article EN cc-by Journal of Medical Internet Research 2024-07-23

Abstract Early and effective discrimination (triage) of patients with inflammatory rheumatic diseases (IRD) other (non-IRD) is essential for successful treatment preventing damage. The aim this study was to investigate diagnostic delays pre-diagnosis in newly presenting rheumatology outpatient clinics. A total 600 one university hospital two non-academic centers were included. Time from onset symptoms consultation “total delay” as well medical before recorded. Median time symptom...

10.1007/s00296-022-05223-z article EN cc-by Rheumatology International 2022-10-10

Rheport is an online rheumatology referral system allowing automatic appointment triaging of new patient referrals according to the respective probability inflammatory rheumatic disease (IRD). Previous research reported that was well accepted among IRD patients. Its accuracy was, however, limited, currently being based on expert-based weighted sum score. This study aimed evaluate whether machine learning (ML) models could improve this limited accuracy.Data from a national registry (RHADAR)...

10.3389/fmed.2022.954056 article EN cc-by Frontiers in Medicine 2022-07-22

More efficient means of identifying patients with inflammatory rheumatic diseases (IRDs) could allow earlier diagnosis and treatment. The objective this study was to evaluate the characteristics a revised version an online patient questionnaire-based self-referral tool, RhePort 1.3. This prospective included adult musculoskeletal complaints presenting for first rheumatology visit at German RheumaDatenRhePort (RHADAR) network centers. All completed 1.3 questionnaire on symptoms. Data from...

10.1007/s00296-025-05861-z article EN cc-by-nc-nd Rheumatology International 2025-04-28

Real-world data are crucial to continuously improve the management of patients with rheumatic and musculoskeletal diseases (RMDs). The German RheumaDatenRhePort (RHADAR) registry encompasses a network rheumatologists researchers in Germany providing pseudonymized real-world patient allowing timely continuous improvement care RMD patients. RHADAR modules allow automated anamnesis adaptive coordination appointments regarding individual urgency levels. Further focus on collection integration...

10.2196/28164 article EN cc-by Journal of Medical Internet Research 2021-04-30

Abstract In recent years Janus kinase inhibitors (JAKi) have joined tumor necrosis factor (TNFi) and interleukin (IL)-17 (IL-17i) as approved disease modifying anti-rheumatic drugs (DMARD) for moderate to severe forms of axial spondyloarthritis (axSpA). Drug survival in axSpA patients has not been well studied a real-world outpatient scenario since the approval JAKi. We aimed analyze three drug classes based on modes actions (MoA) their persistence rates among German outpatients. A...

10.1007/s00296-024-05671-9 article EN cc-by Rheumatology International 2024-08-13

Background Safety recommendations for Janus kinase inhibitors (JAKi) issued by the European Medical Agency (EMA) in 2023 could potentially influence treatment patterns rheumatoid arthritis (RA) drugs, but little is known about impact of these routine clinical care. Methods We retrospectively analyzed German RHADAR rheumatology database adult patients with RA and documentation a new therapy JAKi, tumor necrosis factor inhibitor (TNFi), or interleukin-6 receptor (IL-6Ri). Data were grouped...

10.3389/fimmu.2024.1445680 article EN cc-by Frontiers in Immunology 2024-08-22

<sec> <title>UNSTRUCTURED</title> Real-world data are crucial to continuously improve the management of patients with rheumatic and musculoskeletal diseases (RMDs). The German RheumaDatenRhePort (RHADAR) registry encompasses a network rheumatologists researchers in Germany providing pseudonymized real-world patient allowing timely continuous improvement care RMD patients. RHADAR modules allow automated anamnesis adaptive coordination appointments regarding individual urgency levels. Further...

10.2196/preprints.28164 preprint EN 2021-02-23

<h3>Background</h3> Inflammatory rheumatic diseases (IRD) are often diagnosed too late due to non-specific symptoms and the lack of specialists in rheumatology. Digital diagnostic decision support systems (DDSS) promise accelerate diagnosis decrease overall healthcare burden. <h3>Objectives</h3> To assess ability an artificial intelligence (AI)-based symptom checker (Ada) online self-referral tool (Rheport) diagnose inflammatory (IRD). <h3>Methods</h3> In a prospective, multicenter...

10.1136/annrheumdis-2023-eular.1206 article EN Annals of the Rheumatic Diseases 2023-05-30

Background: Symptom checkers (SC) promise to reduce diagnostic delay, misdiagnosis and effectively guide patients through healthcare systems. They are increasingly used, however little evidence exists about their real-life effectiveness. Objectives: The aim of this study was evaluate the accuracy, usage time, usability perceived usefulness two promising SC, ADA ( www.ada.com ) Rheport www.rheport.de ). Furthermore, symptom duration previous checking recorded. Methods: Cross-sectional interim...

10.1136/annrheumdis-2020-eular.1604 article EN Annals of the Rheumatic Diseases 2020-06-01

This longitudinal analysis compares the prevalence of depressive symptoms in patients with psoriatic arthritis context COVID-19 pandemic. Data from a national patient register Germany were analyzed regarding Patient Health Questionnaire 2 (PHQ-2) to identify cases suspicious for depression at two time points, i.e., before and during Only complete concurrent information on Disease Activity Psoriatic Arthritis Score (DAPSA) included analysis. The frequency pandemic did not differ rates...

10.3389/fmed.2021.748262 article EN cc-by Frontiers in Medicine 2021-11-01

Zusammenfassung Heutzutage haben medizinische Gesundheits-Applikationen (Apps) einen zunehmenden Stellenwert. Auf nahezu jedem neuen Smartphone sind installiert. RheCORD, eine Applikation in der Rheumatologie, wird im Folgenden beschrieben und medizinischen Kontext bewertet. Einsatzmöglichkeiten,Vorteile Limitationen werden beschrieben.

10.1055/a-2113-5577 article DE Aktuelle Rheumatologie 2023-08-01

<sec> <title>BACKGROUND</title> The diagnosis of inflammatory rheumatic diseases (IRDs) is often delayed due to unspecific symptoms and a shortage rheumatologists. Digital diagnostic decision support systems (DDSSs) have the potential expedite help patients navigate health care system more efficiently. </sec> <title>OBJECTIVE</title> aim this study was assess accuracy mobile artificial intelligence (AI)–based symptom checker (Ada) web-based self-referral tool (Rheport) regarding IRDs....

10.2196/preprints.55542 preprint EN 2023-12-15

Auf dem schwermetallreichen Halbtrockenrasen des Breiniger Bergs, dessen bedeutendste Pflanzengesellschaft das Violetum calaminare Schwick. 1931 ist, wurden insgesamt 284 Schmetterlingsarten in einem Zeitraum von vier Jahren (1976—1979) ermittelt und, soweit möglich, den verschiedenen Pflanzengesellschaften zugeordnet. Ungefähr 32,4% aller vorkommenden Arten stehen auf der „Roten Liste“ Nordrhein-Westfalen gefährdeten Schmetterlinge und Bundesrepublik Deutschland Falter, Tagfaltern sogar...

10.21248/decheniana.v134.4062 article DE Decheniana Verhandlungen des Naturhistorischen Vereins der Rheinlande und Westfalens 1981-01-01

Background: There is some evidence that neuropsychiatric changes occur in systemic lupus(1) and rheumatoid arthritis(2). However, little known regarding a possible disease-related impairment of cognitive abilities axial spondyloarthritis (axSpA). Objectives: To evaluate patients with axSpA impairments. Methods: Patients attending two rheumatology practices were routinely evaluated by rheumatologists underwent computer-based memory attention test (MAT) (3, 4) subscale scores ranging from 0...

10.1136/annrheumdis-2021-eular.1353 article EN Annals of the Rheumatic Diseases 2021-05-19

Von 1981-1984 wurden auf der Drover Heide, einem Truppenübungsplatz bei Düren, 417 Falterarten nachgewiesen, davon 28 Tagfalterarten, 84 Spinner und Schwärmer, 168 Eulenfalter 137 Spannerarten. diesen Arten sind 102 = 24,5% in den Roten Listen von Nordrhein-Westfalen Bundesrepublik Deutschland aufgeführt. Die wichtigsten werden pflanzensoziologischen Strukturen Heide zugeordnet. Anhand des Falterbestandes wird die Naturschutzwürdigkeit begründet.

10.21248/decheniana.v140.4269 article DE Decheniana Verhandlungen des Naturhistorischen Vereins der Rheinlande und Westfalens 1987-01-01
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