A5101504400- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Acute Lymphoblastic Leukemia research
- Ubiquitin and proteasome pathways
- Cancer therapeutics and mechanisms
- Histone Deacetylase Inhibitors Research
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Virus-based gene therapy research
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Natural Antidiabetic Agents Studies
- Ideological and Political Education
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- Neonatal Health and Biochemistry
- Curcumin's Biomedical Applications
- Breast Cancer Treatment Studies
- RNA and protein synthesis mechanisms
Chengdu University of Traditional Chinese Medicine
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Guangzhou Chest Hospital
2017-2025
Longyan University
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2020-2022
Shanghai University of Traditional Chinese Medicine
2020-2022
Shenyang Pharmaceutical University
2015-2022
Suzhou Institute of Biomedical Engineering and Technology
2022
Chinese Academy of Sciences
2022
African Americans have a disproportionate burden of aggressive young-onset breast cancer. Genomic testing for inherited predisposition to cancer is increasingly common in clinical practice, but comprehensive mutation profiles remain unknown most minority populations. We evaluated 289 patients who self-identified as American with primary invasive and personal or family history tumor characteristics associated high genetic risk all classes germline mutations known susceptibility genes using...
Inherited mutations in the BRCA1 and BRCA2 genes are strongest genetic predictors of breast cancer primary causes familial breast/ovarian syndrome. The frequency, spectrum penetrance mutant BRCA1/BRCA2 alleles have been determined for several populations, but little information is available populations African ancestry, who suffer a disproportionate burden early onset cancer. We performed complete sequence analysis all exons intron-exon boundaries 434 Nigerian patients from University...
Imaging techniques can provide information about the tumor non-invasively and have been shown to underlying genetic makeup. Correlating image-based phenotypes (radiomics) with genomic analyses is an emerging area of research commonly referred as "radiogenomics" or "imaging-genomics". The purpose this study was assess potential for using automated, quantitative radiomics platform on magnetic resonance (MR) breast imaging inferring activity clinically relevant gene pathways derived from RNA...
Multiple breast cancer susceptibility loci have been identified in genome-wide association studies (GWAS) populations of European and Asian ancestry using array chips optimized for ancestry. It is important to examine whether these are associated with risk women African We evaluated 25 single nucleotide polymorphisms (SNPs) at 19 a pooled case–control study cancer, which included 1509 cases 1383 controls. Cases controls were enrolled Nigeria, Barbados the USA; all found significant...
Upregulated de novo lipogenesis (DNL) plays a pivotal role in the progress of nonalcoholic fatty liver disease (NAFLD). Cytoplasmic citrate flux, mediated by plasma membrane transporter (SLC13A5), mitochondrial carrier (SLC25A1), and ATP-dependent lyase (ACLY), determines central carbon source for acetyl-CoA required DNL. Curcumin, widely accepted dietary polyphenol, can attenuate lipid accumulation NAFLD. Here, we first investigated lipid-lowering effect curcumin against NAFLD oleic...
Abstract BACKGROUND: It has been demonstrated that the partner and localizer of breast cancer 2 (PALB2) acts as a bridging molecule between 1 (BRCA1) BRCA2 proteins is responsible for facilitating BRCA2‐mediated DNA repair. Truncating mutations in PALB2 gene reportedly are enriched patients with Fanconi anemia various populations. METHODS: The authors evaluated contribution germline 279 African American women cancer, including 29 strong family history, moderate 75 weak 146 nonfamilial or...
ABSTRACT Background Avian leukosis virus subgroup J (ALV‐J) primarily affects poultry, particularly chickens, leading to tumourigenesis and immunosuppression, which results in substantial economic losses. It is important note that ALV‐J commonly found indigenous chicken breeds China, the virus's vertical transmission characteristics present a significant threat preservation of local breeds. Objectives The study aimed investigate effects recombinant strain LY2021J , with focus on its genetic...
This study investigates the epidemic trend of pyrazinamide (PZA)-resistant tuberculosis in Southern China over 11 years (2012–2022) and evaluates mutation characteristics PZA resistance-related genes (pncA, rpsA, panD) clinical Mycobacterium (M. tuberculosis) isolates. To fulfil these goals, we analyzed phenotypic resistance 14,927 isolates for which Bactec MGIT 960 drug susceptibility testing (DST) results were available, revealing that 2,054 (13.76%) resistant to PZA. After evaluating...
Liver fibrosis is a globally prevalent chronic liver disease, often representing the advanced stage of various conditions. Despite its widespread occurrence, there currently no widely accepted or effective treatment for fibrosis. However, increasing evidence supports efficacy Traditional Chinese Medicine (TCM) in inhibiting progression In this study, we explored effects and potential mechanisms Qizhu-Ruogan-Granules (QZRG), formulation from Affiliated Hospital Chengdu University TCM, on...
Numerous single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified by genome-wide association studies (GWAS). However, these SNPs were primarily discovered and validated in women of European Asian ancestry. Because linkage disequilibrium is ancestry-dependent heterogeneous among racial/ethnic populations, we evaluated common genetic variants at 22 GWAS-identified loci a pooled sample 1502 cases 1378 controls African None the GWAS index could be...
The objective of this study was to investigate variations in <i>UGT1A1</i> polymorphisms and haplotypes among African-American Caucasian women assess whether variants other than <i>UGT1A1</i>*<i>28</i> are associated with total serum bilirubin levels. (TA)<i><sub>n</sub></i> repeats 14 single nucleotide (SNPs) the gene were genotyped 335 African Americans 181 Caucasians. Total levels available a subset 125 women. Allele frequencies all SNPs significantly different between In Caucasians,...
The leukemogenic membrane glycoprotein gp55, encoded by Friend spleen focus-forming virus (SFFV), induces erythroid cell proliferation through its interaction with the erythropoietin receptor (EPO-R). There are two forms of gp55 in SFFV-infected cells: an intracellular form (more than 95% total protein), which is localized within endoplasmic reticulum (ER) membranes, and a surface (about 3 to 5%). Because both viral proteins bind EPO-R, it not clear whether protein mitogenesis...
Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is growing public health problem. Numerous studies have indicated that bioactive compounds from herbal medicine beneficial effects on T2DM prevention treatment, owing to their numerous biological properties. Curcumin, the major curcuminoid of turmeric, one most studied components supplements, has variety activities. Clinical trials preclinical research recently produced compelling data demonstrate crucial...