A5041801276- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Cancer Cells and Metastasis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Prenatal Screening and Diagnostics
- Geomagnetism and Paleomagnetism Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Fiber Optic Sensors
- Advanced Surface Polishing Techniques
- Electrowetting and Microfluidic Technologies
- Electrodeposition and Electroless Coatings
- Inertial Sensor and Navigation
- Magnetic Field Sensors Techniques
- Corrosion Behavior and Inhibition
- Fetal and Pediatric Neurological Disorders
- Cancer Genomics and Diagnostics
- Advanced materials and composites
- Diamond and Carbon-based Materials Research
- Nanoplatforms for cancer theranostics
- Railway Engineering and Dynamics
- Nanocluster Synthesis and Applications
- Structural Health Monitoring Techniques
- Statistical and numerical algorithms
- Semiconductor materials and devices
China Three Gorges University
2023
China Earthquake Administration
2021-2023
Institute of Geology and Geophysics
2021
Wuhan University
2011-2018
Zhongnan Hospital of Wuhan University
2015
For decades, poly(ethylene glycol) (PEG) has been widely incorporated into nanoparticles for evading immune clearance and improving the systematic circulation time. However, recent studies have reported a phenomenon known as “accelerated blood (ABC)” where second dose of PEGylated nanomaterials is rapidly cleared when given several days after first dose. Herein, we demonstrate that natural red cell (RBC) membrane superior alternative to PEG. Biomimetic RBC membrane‐coated Fe 3 O 4 (Fe @RBC...
Abstract Upconversion nanoparticles (UCNPs), with fascinating optical and chemical features, are a promising new generation of fluorescent probes. Although UCNPs have been widely used in diagnosis therapy, there is an unmet need for simple effective surface engineering method that can produce cancer‐targeting UCNPs. Here, we show by coating particles macrophage membranes, it becomes possible to utilize the adhesion between macrophages cancer cells targeting. Natural membranes along their...
Background: Circulating tumor cells (CTCs) are a burgeoning topic in cancer biomarker discovery research with minimal invasive blood draws. CTCs can be used as potential biomarkers for disease prognosis, early diagnosis and pharmacodynamics. However, the extremely low abundance of limits their clinical utility because technical challenges such isolation subsequent detailed molecular functional characterization rare from patient samples. Methods: In this study, we present novel density...
As "liquid biopsies", circulating tumor cells (CTCs) have been thought to hold significant insights for cancer diagnosis and treatment. Despite the advances of microfluidic techniques that improve capture CTCs a certain extent, recovering captured with enhanced purity at same time remains challenge. Here, by combining on-chip purification off-chip enzymatic treatment, we demonstrate two-stage strategy enhance from blood samples. The introduces stirring flow increase sensitivity decrease...
Microfluidics-based circulating tumor cell (CTC) isolation is achieved by using gelatin-coated silica microbeads conjugated to CTC-specific antibodies. Bead-binding selectively enlarges target size, providing efficient high-purity capture. CTCs captured can be further released non-invasively. This stratagem enables high-performance CTC for subsequent studies. As a service our authors and readers, this journal provides supporting information supplied the authors. Such materials are peer...
This paper introduces a cancer cell capture/release microchip based on the self-sacrificed MnO2 nanofibers. Through electrospinning, lift-off and soft-lithography procedures, nanofibers are tactfully fabricated in microchannels to implement enrichment release of cells liquid samples. The nanofiber net which mimics extra cellular matrix can lead high capture ability with help cell-specific antibody bio-conjugation. Subsequently, an effective friendly method is carried out by using low...
Detection of detached fetal nucleated red blood cells (fNRBCs) in the maternal peripheral may serve as a prospective testing method competing with cell-free DNA, non-invasive prenatal (NIPT).Methods: Herein, we introduce facile and effective lab-on-a-chip fNRBCs detection using capture-releasing material that is composed biotin-doped polypyrrole nanoparticles.To enhance local topographic interactions between nano-components fNRBC, specific antibody, CD147, coated on nanostructured substrate...
Cell-free DNA has been widely used in non-invasive prenatal diagnostics (NIPD) nowadays. Compared to these incomplete and multi-source fragments, fetal nucleated red blood cells (fNRBCs), once as an aided biomarker monitor potential pathological conditions, have re-attracted research interest NIPD because of their definite source the total genetic information contained nuclei. Isolating from maternal peripheral subsequent cell-based bio-analysis make maximal diagnosis possible, while causing...
A CTCs detection assay using transparent MnO2 nanospheres thin films to capture and release of is reported. The enhanced local topography interaction between extracellular matrix scaffolds the antibody-coated substrate leads improved efficiency. captured from artificial blood sample can be cultured released, represent a new functional material capable isolation culture for subsequent studies.
Abstract In this paper, autofluorescent gelatin nanoparticles were synthesized as matrix metalloproteinase (MMP) responsive probes for cancer cell imaging. A modified two‐step desolvation method was employed to generate these whose size controllable and had stable autofluorescence. As glutaraldehyde introduced the crosslinking agent, generation of Schiff base (CN) double carbon bond (CC) between endowed distinct Considering MMPs usually overexpressed on surface cells they degradation...
Non-invasive prenatal diagnostics (NIPD) has been an emerging field for diagnosis research. Carrying the whole genome coding of fetus, fetal nucleated red blood cells (FNRBCs) have pursued as a surrogate biomarker traveling around in maternal blood. Here, by combining unique microbead-based centrifugal separation and enzymatic release, we demonstrated novel method FNRBC isolation from samples. First, gelatin-coated silica microbeads were modified with FNRBC-specific antibody (anti-CD147) to...
Through-Silicon-Via (TSV) technology is of crucial importance in the process defect-free copper filling vias. In this study, small molecule 2-mercapto-1-methylimidazole (SN2) proposed as a new leveler. It enables bottom-up super-filling blind vias without need for inhibitors. Atomic force microscopy (AFM), X-ray diffraction (XRD), and XPS were employed to characterize surface morphology, crystal structure, adsorption properties crystals these systems. Meanwhile, by means electrochemical...
Abstract: Circulating tumor cells (CTCs) in the blood which have detached from both primary and any metastases may be considered as a “liquid biopsy” are expected to replace biopsies monitoring of treatment response determining patient prognosis. Here, we introduce facile efficient CTC detection material made hydroxyapatite/chitosan (HA/CTS), is beneficial because its transparency excellent biological compatibility. Atomic force microscopy images show that roughness HA/CTS nanofilm...
Background: Capture and identification of circulating tumor cells (CTCs) in the blood system can help guide therapy predict prognosis cancer patients.However, simultaneous capture CTCs with both epithelial mesenchymal phenotypes remains a formidable technical challenge for research.This study aimed at developing to efficiently identify these heterogeneous using transparent nanomaterials quantum dots (QDs)-based multiplexed imaging.Methods: Hydroxyapatite-chitosan (HA-CTS) nanofilm-coated...
Single-crystal sapphire (α-Al2O3) has been widely used in semiconductor, optics, communication, national defense, and other fields. Before application, an ultra-smooth surface which is scratch free subsurface damage essential. Furthermore, the unique qualities such as significant rigidity chemical stability, make it extremely arduous to process. Chemical mechanical polishing (CMP) recognized final process reduce roughness eliminate defects of a surface. In this review, materials equipment...