A5026050214- Management of metastatic bone disease
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Brain Metastases and Treatment
- RNA Research and Splicing
- Sarcoma Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Tumor Diagnosis and Treatments
- Spine and Intervertebral Disc Pathology
- Histone Deacetylase Inhibitors Research
- Adenosine and Purinergic Signaling
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Tumors and Oncological Cases
- Epigenetics and DNA Methylation
- Cervical and Thoracic Myelopathy
Brown University
2023-2024
Rhode Island Hospital
2023-2024
Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including treatment with chemotherapy. Here, we show that micro-RNA regulation of variance expression DNA repair protein methyl- guanine methyl transferase (MGMT) contributes this and acquired therapeutic resistance. In cell lines derived from glioblastomas, most common form primary brain tumor, standard-of-care temozolomide chemotherapy triggers feed-forward...
Background: Schwann cells (SCs) and their plasticity contribute to the peripheral nervous system's capacity for nerve regeneration after injury. The Egr2/Krox20 promoter antisense RNA (Egr2-AS) recruits chromatin remodeling complexes inhibit Egr2 transcription following Methods: RNA-seq ATAC-seq were performed on control cells, Lenti-GFP-transduced overexpressing Egr2-AS (Lenti-AS). AS-RNA was cloned into pLVX-DsRed-Express2-N1 lentiviral expression vector (Clontech, Mountain View, CA, USA),...