- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Human Health and Disease
- Retinal Diseases and Treatments
- Healthcare Systems and Public Health
- Physical Education and Training Studies
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Analytical chemistry methods development
- Legionella and Acanthamoeba research
- Allergic Rhinitis and Sensitization
- Pharmacological Effects and Toxicity Studies
- Microfluidic and Capillary Electrophoresis Applications
- Mycobacterium research and diagnosis
- Genetics, Bioinformatics, and Biomedical Research
- Signaling Pathways in Disease
- Emotional Intelligence and Performance
- Ectopic Pregnancy Diagnosis and Management
- Drug-Induced Ocular Toxicity
- Digital Economy and Work Transformation
University of Alabama at Birmingham
2024
Singapore General Hospital
2000-2023
Ministry of Health
2023
Singapore National Eye Center
2008-2022
Duke-NUS Medical School
2017-2022
National University of Singapore
2018-2021
Singapore Eye Research Institute
2011-2021
Astana Medical University
2021
Tan Tock Seng Hospital
2015-2017
Bausch & Lomb (France)
2015
To investigate the efficacy of SCORE Analyzer (Bausch+Lomb TechnoLas, Germany) in detecting forme fruste keratoconus (FFKC) Asian eyes and validate its usefulness as a risk assessment system for post-laser situ keratomileusis (LASIK) keratectasia.We retrospectively evaluated corneal topographies with Orbscan IIz independently tested them through masked investigators. Eyes were classified into 2 groups: (1) The FFKC group included clinically topographically normal definite contralateral eye....
The initial published clinical report on riboflavin/ultraviolet A corneal cross-linking (CXL) for treatment of progressive keratoconus dates back to 2003. CXL has since then been widely used outside the United States and post-laser in situ keratomileusis ectasia. Food Drug Administration (FDA) approved Avedro Inc.'s system (KXL) patients with ectasia April 2016. procedure is not currently stable keratoconus. There are 2 FDA-approved topical ophthalmic solutions use CXL. Riboflavin...
To describe higher order ocular aberrations in eyes with keratoconus.Prospective, observational, case-control study comparing patients keratoconus control subjects myopia.One hundred sixteen were recruited. Data analyzed 35 eyes, 38 suspect and 166 right myopia. Mean total root-mean-square (RMS) values (3rd to 5th order) 1.73 +/- 0.71 microm keratoconus, 0.94 0.66 suspect, 0.49 0.16 eyes. Keratoconus had greater RMS, 3rd RMS for all Zernike terms than those the group (P < .001).Keratoconus...
A retrospective study of 18 patients with malignant tumors the external auditory canal and temporal bone was undertaken to gain an Asian perspective this rare disease. Of these patients, 15 (83%) had squamous cell carcinoma (SCC) 61% stage T3 at presentation. The mean age 56 years (range 38-82 years). Seven (39%) radiation-associated (RATs), all undergone radiotherapy for treatment nasopharyngeal carcinoma. 1-year cumulative recurrence RAT group 100%, but there no in non-RAT (P = 0.001). In...
Objective: The aim was to compare the visual, refractive, topographic and biomechanical outcomes in patients with progressive keratoconus treated either conventional or accelerated crosslinking at one year follow up. Methods: It is a prospective, non-randomised interventional study of 76 who underwent (CXL; 3mW/cm 2 for 30 minutes) cross linking (KXL; 30mW/cm 4 keratoconus. Baseline postoperative visual acuity, manifest refraction, corneal topography, pachymetry, endothelial cell density...
ABSTRACT PURPOSE: To describe the characteristics of higher order ocular aberrations adult Chinese eyes with myopia. METHODS: Higher in consecutive right 166 patients myopia who enrolled for preoperative assessment LASIK were retrospectively reviewed. Wavefront measured Bausch & Lomb Zywave over a 6-mm dilated pupil. The correlations between and myopia, astigmatism, age, respectively, analyzed. RESULTS: Mean patient age was 32.1±6.2 years, mean refractive error sphere -5.23±1.79 diopters...
To evaluate the characteristics of unilateral keratoconus defined on basis corneal topography and analyze videokeratography parameters between fellow eyes normal controls.A total 111 patients with clinical were prospectively enrolled. Both evaluated Tomey (Tomey Corp) Orbscan II (Bausch & Lomb) systems. The patient was classified as having if one eye had other did not have any topographic signs such asymmetric videokeratographic pattern, positive result in screening, maximum posterior...
Riboflavin–UV-A corneal collagen cross-linking (CXL) is a new technique that aims to arrest keratoconus progression. Riboflavin adsorbed stromal fibers activated by UV-A light, with the formation of cross-links between fibrils confer greater rigidity.1
The aim was to describe the contact lens characteristics and contrast sensitivity of patients with keratoconus managed conservatively contacts lenses at a tertiary eye center in Singapore.A prospective cross-sectional study 116 clinically evident or suspected (on videokeratography) recruited over 11 months. Demographic medical details, visual acuity (VA) refraction, corneal topography were documented. Contrast performed Vision Test System 6500 under standardized conditions.Overall, 67%...
<b>Aim:</b> 10 eyes of patients are reported where progression keratoconus in the host cornea occurred more than years after penetrating keratoplasty with resultant increase astigmatism. The technique and results graft refractive surgery seven presented. <b>Methods:</b> clinical features management these were retrospectively analysed. Graft involved an incision at graft-host junction adjacent to thinning compressive resuturing. Astigmatic changes calculated using vector analysis....
ABSTRACT Purpose : To determine the in vitro drug susceptibility of Australian corneal isolates Acanthamoeba and to correlate results with patient treatment visual outcome. Methods were obtained from a reference laboratory. Cyst suspensions prepared 19 strains exposed 10 antimicrobial agents for 7 days. The minimum concentrations required inhibit excystation determined. Inhibited cells then plated out cysticidal concentrations. Results Overall, propamidine proved be most active anti‐ agent...
The purpose of this article is to provide a framework for general ophthalmologists in Singapore manage dry eye. This considers the evidence literature as well recommendations from expert panels such Tear Film & Ocular Surface Society Dry Eye Workshop II and Asia Cornea Workgroup.This covers assessment patient medical history ask triage questions identify local systemic causes eye disease (DED), excluding other possible causes, risk factors DED ocular surface inflammation. Evaluation clinical...
Purpose To report a case of Pseudomonas aeruginosa culture-positive microbial keratitis in patient wearing continuous-wear silicone hydrogel soft contact lenses. Methods A 23-year-old white woman good health had been (lotrafilcon A) lenses continuously for 26 days when she was examined corneal ulcer her left eye. She given history water jet skiing and diving while Scrapings the were positive P. aeruginosa, treated with fortified topical cefazolin gentamicin 1 week subsequently ciprofloxacin...