A5063845428- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Multisensory perception and integration
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Axon Guidance and Neuronal Signaling
- Cell Image Analysis Techniques
- Color perception and design
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Electrochemical Analysis and Applications
University College London
2021-2025
National Hospital for Neurology and Neurosurgery
2024-2025
Sainsbury Laboratory
2021-2024
University of Cambridge
2018-2024
Shenzhen Institutes of Advanced Technology
2021
Sensory cortices can be affected by stimuli of multiple modalities and are thus increasingly thought to multisensory. For instance, primary visual cortex (V1) is influenced not only images but also sounds. Here we show that the activity evoked sounds in V1, measured with Neuropixels probes, stereotyped across neurons even mice. It independent projections from auditory resembles hippocampal formation, which receives little direct input. Its low-dimensional nature starkly contrasts...
The brain can combine auditory and visual information to localize objects. However, the cortical substrates underlying audiovisual integration remain uncertain. Here, we show that mouse frontal cortex combines evidence; this combination is additive, mirroring behavior; it evolves with learning. We trained mice in an localization task. Inactivating impaired responses either sensory modality, while inactivating or parietal affected only stimuli. Recordings from >14,000 neurons indicated after...
MotivationMicroelectrode array (MEA) recordings of neuronal activity are an essential functional assay for evaluating in vitro models neurodevelopment and neurological diseases. However, most studies limited to comparing firing burst rates. We have previously shown that 3D human cerebral organoids develop microscale networks. The network-level features, which predict cellular-scale information processing efficiency, can provide a bioinformatic phenotype network function MEA from tissues....
Summary To make accurate perceptual decisions, the brain often combines information across sensory modalities. For instance, localizing objects by integrating their image and sound. However, cortical substrates underlying this audiovisual integration remain uncertain. Here, we show that mouse frontal cortex auditory visual evidence; combination is additive, mirroring behavior; it evolves with learning. Scanning optogenetic inactivation demonstrated inactivating impaired choices based on...
Summary Microelectrode array (MEA) recordings are commonly used to compare firing and burst rates in neuronal cultures. MEA can also reveal microscale functional connectivity, topology, network dynamics—patterns seen brain networks across spatial scales. Network topology is frequently characterized neuroimaging with graph theoretical metrics. However, few computational tools exist for analyzing from recordings. Here, we present a MATLAB analysis pipeline (MEA-NAP) raw voltage time-series...
Three-dimensional neural organoids are emerging tools with the potential for improving our understanding of human brain development and neurological disorders. Recent advances in this field have demonstrated their capacity to model neurogenesis 1,2 , neuronal migration positioning 3,4 even response sensory input 5 . However, it remains be seen whether these tissues can axon guidance dynamics formation complex connectivity functional output. Here, we established a longterm air-liquid...
Sensory cortices can be affected by stimuli of multiple modalities and are thus increasingly thought to multisensory. For instance, primary visual cortex (V1) is influenced not only images but also sounds. Here we show that the activity evoked sounds in V1 highly stereotyped across neurons even mice. It resembles measured elsewhere brain independent projections from auditory cortex. Its low-dimensional nature starkly contrasts high dimensional code uses represent images. Furthermore, this...