A5043081289- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Calcium signaling and nucleotide metabolism
- Parkinson's Disease Mechanisms and Treatments
- Cell death mechanisms and regulation
- Cholinesterase and Neurodegenerative Diseases
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Biochemical Acid Research Studies
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Neonatal and fetal brain pathology
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Neurotransmitter Receptor Influence on Behavior
- Phagocytosis and Immune Regulation
- Cardiac electrophysiology and arrhythmias
- Nicotinic Acetylcholine Receptors Study
Universidade de São Paulo
2021-2025
Institute of Biomedical Science
2025
University of Birmingham
2019-2023
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2016-2020
University of Coimbra
2010-2020
Centro de Neurociências e Biologia Celular
2014
Universidade Federal de São Paulo
2003-2010
University of Toronto
1980
Autophagy is a homeostatic process critical for cellular survival, and its malfunction implicated in human diseases including neurodegeneration. Loss of autophagy contributes to cytotoxicity tissue degeneration, but the mechanistic understanding this phenomenon remains elusive. Here, we generated autophagy-deficient (ATG5−/−) embryonic stem cells (hESCs), from which established neuronal platform investigate how loss affects survival. ATG5−/− neurons exhibit basal accompanied by metabolic...
Mitochondrial dysfunction involving mitochondria-associated ER membrane (MAM) dysregulation is implicated in the pathogenesis of late-onset neurodegenerative diseases, but understanding limited for rare early-onset conditions. Loss MAM-resident protein WFS1 causes Wolfram syndrome (WS), a disease that has been linked to mitochondrial abnormalities. Here we demonstrate human induced pluripotent stem cell-derived neuronal cells WS patients. VDAC1 identified interact with WFS1, whereas loss...
Abstract Intracellular calcium homeostasis is important for cell survival. However, increase in mitochondrial (Ca 2+ m ) induces opening of permeability transition pore (PTP), dysfunction and apoptosis. Since alterations intracellular Ca reactive oxygen species (ROS) generation are involved death, they might be neurodegenerative processes such as Huntington's disease (HD). HD characterized by the inhibition complex II respiratory chain ROS production. In this report, we studied correlation...
Transcriptional deregulation and changes in mitochondrial bioenergetics, including pyruvate dehydrogenase (PDH) dysfunction, have been described Huntington's disease (HD). We showed previously that the histone deacetylase inhibitors (HDACIs) trichostatin A sodium butyrate (SB) ameliorate function cells expressing mutant huntingtin. In this work, we investigated effect of HDACIs on regulation PDH activity striatal derived from HD knock-in mice YAC128 mice. Mutant exhibited decreased increased...
Abstract The sensory neurons in the olfactory epithelium (OSNs) are equipped with a large repertoire of receptors and associated signal transduction machinery. In addition to canonical OSNs, which express odorant (ORs), contains specialized subpopulations that can detect specific information from environmental cues relay it relevant neuronal circuitries. Here we describe subpopulation mature OSNs main (MOE) expresses CD36, multifunctional receptor involved series biological processes,...
Abstract Amyotrophic lateral sclerosis (ALS) is a multifactorial and progressive neurodegenerative disease of unknown etiology. Due to ALS’s unpredictable onset progression rate, the search for biomarkers that allow detection tracking its development therapeutic efficacy would be significant medical value. Considering alterations energy supply are one main hallmarks correlation has been established between gene expression in human brain tissue peripheral blood mononuclear cells (PBMCs),...
Abstract Schizophrenia (SZ) is a multifactorial mental disorder, which has been associated with number of environmental factors, such as hypoxia. Considering that numerous neural mechanisms depends on energetic supply (ATP synthesis), the maintenance mitochondrial metabolism essential to keep cellular balance and survival. Therefore, in present work, we evaluated functional parameters related function, namely calcium levels, membrane potential, redox homeostasis, high-energy compounds levels...