A5031260724- Zebrafish Biomedical Research Applications
- Nanoplatforms for cancer theranostics
- Analytical chemistry methods development
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Molecular Sensors and Ion Detection
- TGF-β signaling in diseases
- Melanoma and MAPK Pathways
- Mass Spectrometry Techniques and Applications
- Pluripotent Stem Cells Research
- Epoxy Resin Curing Processes
- Pickering emulsions and particle stabilization
- Synthesis and properties of polymers
- interferon and immune responses
- Extraction and Separation Processes
- Liver Disease Diagnosis and Treatment
- Surfactants and Colloidal Systems
- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- Luminescence and Fluorescent Materials
- Hydrogels: synthesis, properties, applications
- Lung Cancer Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Tianjin haihe hospital
2017-2025
Northwest A&F University
2022-2025
Sichuan Agricultural University
2025
Tianjin University
2025
Taian City Central Hospital
2023-2024
Qingdao University
2023-2024
First Affiliated Hospital of Gannan Medical University
2022-2024
Jiangnan University
2010-2023
Northwest Institute of Mechanical and Electrical Engineering
2022
University of New Mexico
2019-2021
The in situ surface activation of unmodified CaCO(3) nanoparticles by interaction with surfactant aqueous media has been studied, and the impact this on foamability foam stability dispersions was assessed. Using complementary experiments including measurement particle zeta potentials, adsorption isotherms surfactant, air-water tensions, relevant contact angles, mechanism revealed. results show that non-surface-active cannot be activated cationic or nonionic surfactants but can anionic such...
Abstract Inhibition of VEGF signalling effectively suppresses localized tumour growth but accelerates invasiveness and micrometastasis by unknown mechanisms. To study the dynamic reciprocal interactions between cells their microenvironment during these processes, we established a xenograft model injecting into blood circulation transparent zebrafish embryos. This reproducibly results in rapid simultaneous formation experimental micrometastasis, allowing time‐resolved imaging both processes...
Abstract The recruitment of leukocytes to infectious foci depends strongly on the local release chemoattractant mediators. human CXC chemokine receptor 3 (CXCR3) is an important node in signaling network and expressed by multiple leukocyte lineages, including T cells macrophages. ligands this originate from ancestral CXCL11 gene early vertebrates. Here, we used optically accessible zebrafish embryo model explore function CXCR3-CXCL11 axis macrophage show that disruption increases resistance...
The in situ surface activation of raw CaCO(3) nanoparticles by interaction with a series sodium carboxylates chain length between 6 and 12 as well 2-ethylhexylsulfosuccinate (AOT) was studied, the impact this on stabilization phase inversion toluene-water emulsions assessed. By using complementary experiments including measurement particle zeta potentials, adsorption isotherms amphiphile, relevant contact angles, mechanism revealed. results show that hydrophilic can be activated AOT even if...
As an important physiological indicator, wheat canopy temperature (CT) can be observed after flowering in attempt to predict yield and quality. However, the relationship between CT quality is not clear. In this study, CT, photosynthetic rate (Pn), filling rate, yield, of 68 lines were measured, establish a connection accelerate selection new varieties. This experiment used infrared imaging camera measure materials planted field 2022. Twenty with significant differences selected for planting...
A photodegradable, covalently crosslinked hydrogel system has been constructed from the biocompatible polymers dextran and poly(ethylene glycol) using acrylate–thiol Michael addition as crosslinking method. Light sensitivity of was introduced by placing a non-toxic photolabile o-nitrobenzyl moiety in between backbone acrylate group. Hydrogels were prepared under physiological conditions without need any additional reagents mixing solutions functionalized with acrylate-modified moieties...
The increasing use of zebrafish larvae for biomedical research applications is resulting in versatile models a variety human diseases. These exploit the optical transparency and availability large genetic tool box. Here we present detailed protocols robotic injection embryos at very high accuracy with speed up to 2000 per hour. are benchmarked several applications: (1) DNA obtaining transgenic animals, (2) antisense morpholinos that can be used gene knock-down, (3) microbes studying...
The main purpose of this work was to develop and evaluate a self-emulsifying drug delivery system (SEDDS) piperine enhance its solubility bioavailability. formulation optimized by test ternary phase diagrams. Then physiochemical properties in vitro release SEDDS were characterized. In vivo pharmacokinetics study situ single-pass intestinal perfusion performed investigate the effects on bioavailability absorption piperine. composed ethyl oleate, Tween 80 Transcutol P (3:5.5:1.5, w/w), with...
Cellular senescence, a process that arrests the cell cycle, is cellular response mechanism for various stresses and implicated in aging age-related diseases. However, understanding of senescence living organisms insufficient, largely due to scarcity sensitive tools detection
Chitosan-modified magnetic nanoparticles were synthesized by an emulsion method and characterized. The prepared chitosan-modified exhibit excellent adsorption performance for Cr(III) at pH 9 total Cr (Cr(III) Cr(VI)) 6. Therefore, a new combining solid phase extraction with inductively coupled plasma optical emission spectrometry was developed the speciation of Cr(VI) in environmental water samples. parameters affecting desorption target chromium species, such as pH, time, sedimentation time...
Detection of cellular senescence is important not only in the study various biological systems, but also practical applications such as image-guided surgical removal senescent cells, well monitoring drug-responsiveness during cancer therapies. Due to lack suitable imaging probes for detection, particularly living subjects, we have developed an activatable near-infrared (NIR) molecular probe with far-red excitation, NIR emission, and high "turn-on" ratio upon senescence-associated...
Abstract The transforming growth factor-β (TGF-β) family is known to play critical roles in cancer progression. While the dual role of TGF-β well described, function bone morphogenetic proteins (BMPs) unclear. In this study, we established involvement Smad6, a BMP-specific inhibitory Smad, breast cell invasion. We show that stable overexpression Smad6 MCF10A M2 cells inhibits BMP signalling, thereby mitigating BMP6-induced suppression mesenchymal marker expression. Using zebrafish xenograft...
In many cases, cancer patients do not die of a primary tumor, but rather because metastasis. Although numerous rodent models are available for studying metastasis in vivo, other efficient, reliable, low-cost needed to quickly access the potential effects (epi)genetic changes or pharmacological compounds. As such, we illustrate and explain feasibility xenograft using human breast cells injected into zebrafish embryos support this goal. Under microscope, fluorescent proteins chemically labeled...
BackgroundHuman infections with the H7N9 virus could lead to lung damage and even multiple organ failure, which is closely associated a high mortality rate. However, metabolic basis of such systemic alterations remains unknown.MethodsThis study included hospitalized patients (n = 4) laboratory-confirmed infection, healthy controls 9), two disease control groups comprising pneumonia 9) who received steroid treatment 10). One H7N9-infected patient underwent biopsy for histopathological...
This study aimed to assess the potential relationship between tumor mutation burden (TMB) and recurrence risk of hepatocellular cancer (HCC) after curative resection tried develop a reliable TMB based nomogram.This retrospective was conducted in 128 patients (40 suffered from HCC) who had received radical hepatectomy by same surgical team. A nomogram model constructed using R EmpowerStats software.TMB not associated with maximum size presence microvascular invasion (MVI). In whole population...
Abstract The GH4169 superalloy and SiC ceramic were subjected to vacuum brazing using AgCuTi filler + Cu foam composite filler, respectively. influence of holding time on the microstructure shear strength joint between was investigated. results demonstrate that interface GH4169/SiC consists superalloy/Ag (s, s) +Cu(s,s) /TiNi3+Ti (Cu, Ni)2+Ag(s, s)+ Cu(s,s) +Ti5Si3+TiC /SiC ceramic. As increases, there is a more pronounced diffusion elements matrix leading an increased thickness interfacial...
Abstract Introduction: The second-generation BTK inhibitors (BTKis), e.g., zanu, acalabrutinib (acala), have further transformed the therapy landscape of chronic lymphocytic leukemia (CLL). However, acquired mutations in (mainly at position C481) results covalent BTKi resistance and disease progression. Non-covalent pirtobrutinib (pirto) can overcome C481 mutations, but is susceptible to other like recently described kinase impaired V416L L528W which both maintain downstream signaling....
Hydrogel-based drug carriers have been developed from biocompatible materials, cyclodextrin, dextran and poly(ethylene glycol) were used in zebrafish embryos. Maleimide modified dextrans (Dex-mal) functionalized with cyclodextrins crosslinked to form a hydrogel using either per-6-thio-β-cyclodextrin (PSCD) or combination of mono-6-thio-β-cyclodextrin (MSCD) di-thiolated (DSPEG). Using all-trans retinoic acid (RA) as model hydrophobic drug, sustained release these cyclodextrin hydrogels was...