A5057986818- Genomics and Chromatin Dynamics
- Hearing, Cochlea, Tinnitus, Genetics
- Cardiovascular Health and Disease Prevention
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Cardiovascular Health and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Bioinformatics and Genomic Networks
- Blood Pressure and Hypertension Studies
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Lipoproteins and Cardiovascular Health
- Single-cell and spatial transcriptomics
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- RNA and protein synthesis mechanisms
- Artificial Intelligence in Healthcare
- Bone and Joint Diseases
- Biomimetic flight and propulsion mechanisms
- Evaluation and Optimization Models
- Imbalanced Data Classification Techniques
- Facial Trauma and Fracture Management
- Ear Surgery and Otitis Media
- Machine Learning in Healthcare
University of Michigan
2018-2024
Nanjing University of Aeronautics and Astronautics
2023
National Clinical Research Center for Digestive Diseases
2019
Shanghai Ninth People's Hospital
2019
Shanghai Jiao Tong University
2019
Washtenaw Community College
2018
Auditory hair cells transduce sound to the brain, and in mammals, these reside together with supporting sensory epithelium of cochlea, called organ Corti. To establish organ's delicate function during development differentiation, spatiotemporal gene expression is strictly controlled by chromatin accessibility cell type–specific transcription factors, jointly representing regulatory landscape. Bulk sequencing technology cellular heterogeneity obscured investigations on interplay between...
Objective To identify cell types and signaling pathways that drive cholesteatoma. Methods Single-cell RNA sequencing (scRNA-seq) was applied to differences between human cholesteatoma specimens previously published scRNA-seq data for normal tympanic membrane. The CellChat algorithm determined differential both tissues. Cholesteatoma-specific markers were validated utilizing immunohistochemistry on specimens. Background Cholesteatoma is a complex, expansile, destructive cystic epithelial...
Revealing the gene targets of distal regulatory elements is challenging yet critical for interpreting regulome data. Experiment-derived enhancer-gene links are restricted to a small set enhancers and/or cell types, while accuracy genome-wide approaches remains elusive due lack systematic evaluation. We combined multiple spatial and in silico defining enhancer locations linking them their target genes aggregated across >500 generating 1860 human enhancer-to-target definitions (EnTDefs). To...
Gene set enrichment (GSE) testing enhances the biological interpretation of ChIP-seq data and other large sets genomic regions. Our group has previously introduced two GSE methods for regions: ChIP-Enrich narrow regions Broad-Enrich broad Here, we introduce Poly-Enrich, which wider applicability, additional capabilities models number peaks assigned to a gene using generalized additive model with negative binomial family determine enrichment, while adjusting locus length. As opposed...
In order to improve the sharp return characteristics of flutter mechanism, and then increase downward power aircraft, reduce drag wing upward, flight efficiency, this paper designs a drive mechanism with based on eccentric crank slider structure. Firstly, kinematic model is established through motion analysis, simulation in SOLIDWORKS simulate its verify theoretical analysis. The results show that designed has an upper limit angle 17°, lower -34°, travel speed ratio 1.35, which are...
Recently, a novel 4-tiered classification of left ventricular hypertrophy (LVH) based on dilatation (indexed LV end-diastolic volume [EDV]) and concentricity (mass/EDV0.67) has improved all-cause cardiovascular mortality risk stratification. However, their possible association with ischemic stroke not been extensively evaluated in the general population.We cross-sectional study 11,037 subjects from population China whom echocardiographic data were available to subdivide patients LVH into...
Abstract Although various animal studies have indicated that sensory nerves played an important role in bone metabolism and nerve injury could impair the process of remodeling, actual effect rupture on human bones remains unclear. The aim this preliminary study was to investigate inferior alveolar (IAN) mandibular remodeling patients underwent bilateral sagittal split ramus osteotomy (BSSRO). Ten with unilateral IAN during BSSRO were involved study. Neurosensory examinations employed assess...
Abstract Gene set enrichment (GSE) testing enhances the biological interpretation of ChIP-seq data and other large sets genomic regions. Our group has previously introduced two GSE methods for regions: ChIP-Enrich narrow regions Broad-Enrich broad regions, such as histone modifications. Here, we introduce new extensions that more appropriately analyze with vastly different properties. First, Poly-Enrich, which models number peaks assigned to a gene using generalized additive model negative...
The purpose of this study is to evaluate the frequency pneumothorax following orthognathic surgery and describe its clinical presentation. A retrospective analysis a hospital database was carried out on consecutive patients with normal presurgical assessment, laboratory findings, chest X-ray who underwent from January 2007 September 2018 in Department Oral Craniomaxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School Medicine. Two (0.038%), 1 male (age 20 years)...
Abstract Revealing the gene targets of distal regulatory elements is challenging yet critical for interpreting regulome data. Experiment-derived enhancer-gene links are restricted to a small set enhancers and/or cell types, while accuracy genome-wide approaches remains elusive due lack systematic evaluation. We combined multiple spatial and in silico defining enhancer locations linking them their target genes aggregated across >500 generating 1,860 human En hancer T arget Def initions (...
Abstract Interpreting predictive machine learning models to derive biological knowledge is the ultimate goal of developing in era genomic data exploding. Recently, sequence-based deep have greatly outperformed other such as SVM genome-wide prediction tasks. However, models, which are black-box challenging interpret their predictions. Here we represented an end-to-end computational pipeline, Explain-seq, automate process and interpreting context genomics. Explain-seq takes input sequences...
This paper discusses the operation of grey relational mapping. We define equivalent characteristics mapping and generating order. prove that if mappings are finite, then their maximum, minimum value, weighted average product function also mappings. The necessary sufficient condition two is they can be generated by each other monotonic increasing functions. put forward principle optimum order to obtain a better method carry out analysis.
In the mammalian auditory system, frequency discrimination depends on numerous morphological and physiological properties of organ Corti that gradually change along apex-to-base (tonotopic) axis organ. For example, basilar membrane stiffness changes tonotopically, thus affecting tuning individual hair cells. At molecular level, those frequency-specific characteristics are mirrored by gene expression gradients; however, mechanisms controlling tonotopic in mouse cochlea remain elusive. Through...