A5057900002- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Inflammatory mediators and NSAID effects
- Biochemical effects in animals
- Tuberculosis Research and Epidemiology
- Asthma and respiratory diseases
- Seaweed-derived Bioactive Compounds
- Immune Response and Inflammation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Wound Healing and Treatments
- Hydrogen's biological and therapeutic effects
- Neuropeptides and Animal Physiology
- Mycobacterium research and diagnosis
- Antioxidants, Aging, Portulaca oleracea
- Quinazolinone synthesis and applications
- Regulation of Appetite and Obesity
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
Hacettepe University
2012-2024
Previously, we demonstrated that certain heterocyclic compounds derived from 3‐substituted‐1,2,4‐triazole‐5‐thiones had promising analgesic/anti‐inflammatory activities together with low ulcerogenic properties. Therefore, sought to design and synthesize new derivatives of triazol‐5‐thiones‐fused heterocycles. In the present study, a series novel bis ‐Mannich bases, namely 2,6‐disubstituted‐6,7‐dihydro‐5 H ‐1,2,4‐triazolo[3,2‐ b ]‐1,3,5‐thiadiazines ( 1a–d , 2a–c 3a–d ), were synthesized...
Abstract Starting from the known ibuprofen derivative (I), a series of thiazolo[3,2‐b]‐1,2,4‐triazole‐5(6H)‐ones (IV) are synthesized and evaluated for their in vivo antiinflammatory analgesic activities.
Background and Aims: It has been suggested that thyrotropin-releasing hormone (TRH) may have functions beyond its fundamental regulating function. Previous studies demonstrated TRH promotes wound healing. We aimed to perform an in vitro study fibroblasts assess the role of wounds frequently occur diabetes. Thus, we investigated effects healing both under normoglycemic hyperglycemic-conditions. Methods: L929 mouse fibroblast cell line was used experiments. The viability confirmed with XTT....
Diyabet ve Alzheimer hastalığı nüfusun giderek yaşlanmasıyla beraber görülme sıklığı artan iki hastalıktır. Her hastalık da kronik karmaşık yapıda olduğundan, yaşlı popülasyonda en başta gelen sağlık problemlerindendir. hastalığının yaşlanma, metabolik sendrom, periferik insülin direnci, yüksek kolesterol gibi bilinen birçok risk faktörü bulunmaktadır. Bu çalışmada, ilgili faktörleri arasında yer alan diyabet üzerinde durulması amaçlanmıştır. hastalarının olma ihtimali, aynı yaştaki sağlıklı...
ABSTRACT Objective 5-Hydroxytryptophan is the precursor compound of serotonin biosynthesis. The oral absorption close to 100% and, unlike serotonin, it crosses blood-brain barrier freely. has been used as a food supplement for many years treat anxiety and depression. Recent studies have shown that suppresses pro-inflammatory mediators effective in some inflammatory diseases, such arthritis allergic asthma. However, role supplements on acute peripheral inflammation not investigated yet. In...
Tuberculosis (TB) is still one of the most common infectious diseases around world despite widespread use BCG (bacille Calmette-Guerin) strain Mycobacterium bovis as a vaccine. This vaccine does not always protect people from TB, and, thus, new effective vaccines or vaccination strategies are being investigated. In this study, alkyl hydroperoxide reductase (AhpC) M. was evaluated candidate antigen against TB in BALB/c mice model. The ahpC gene amplified M.bovis genome, cloned, and expressed...