A5017423170- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Stellar, planetary, and galactic studies
- Inflammasome and immune disorders
- interferon and immune responses
- Extracellular vesicles in disease
- Solar and Space Plasma Dynamics
- Mitochondrial Function and Pathology
- IL-33, ST2, and ILC Pathways
- Atmospheric Ozone and Climate
- MicroRNA in disease regulation
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- Cellular transport and secretion
- Neonatal Respiratory Health Research
- Total Knee Arthroplasty Outcomes
- RNA Interference and Gene Delivery
- Nuclear Structure and Function
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- Cell Adhesion Molecules Research
- Orthopaedic implants and arthroplasty
- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
University of Bonn
2020-2025
Zimmer Biomet (Germany)
2021-2025
University Hospital Bonn
2024
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2020-2024
Max Planck Society
2015
Max Planck Institute for Solar System Research
2015
Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I interferon–driven inflammatory diseases. In these pathophysiological conditions, the DNA sensor cGAS and IFN production are linked damage. Physiological, tonic, signaling on other hand is essential functionally prime sensing pathways. Here, we show that low-level chronic damage mice lacking Aicardi-Goutières syndrome gene...
Abstract Detection of tumor progression in patients with glioblastoma remains a major challenge. Extracellular vesicles (EVs) are potential biomarkers and can be detected the blood glioblastoma. In our study, we evaluated serum‐derived EVs from to serve as biomarker for progression. serum healthy volunteers were separated by size exclusion chromatography ultracentrifugation. EV markers defined using proximity‐extension assay bead‐based flow cytometry. Tumor was according modified RANO...
Protamines are the safeguards of paternal sperm genome. They replace most histones during spermiogenesis, resulting in DNA hypercondensation, thereby protecting its genome from environmental noxa. Impaired protamination has been linked to male infertility mice and humans many studies. Apart impaired integrity, protamine-deficient human murine show multiple secondary effects, including decreased motility aberrant head morphology. In this study, we use a Protamine-2 (Prm2)-deficient mouse...
Abstract Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Even among carriers of the same genetic variant, phenotypes vary, indicating that additional factors, such as local immune system, play a role. We observe increase in IL-17A(+)NKp44(−) innate lymphoid type 3 cell (ILC3) FAP, localized near epithelium and enriched adenomas carcinomas. Elevated IL1B , IL23A DLL4 transcript levels correlate IL-17A(+)NKp44(−)ILC3...
Proteins of the cytohesin family are known for their guanine-nucleotide exchange factor function ARF-GTPases, mainly ARF1 and ARF6. While Arf1 Arf6 deficiency results in embryonic lethality, vivo functions cytohesins rarely described mostly inconspicuous. We analyzed role cytohesin-2 vitro found that full knockout mice die within one day after birth. Mass spectrometry-based organellar proteomics wildtype CRISPR-Cas9-generated cytohesin-2-/- C2 myoblasts revealed a markedly altered Golgi...
Accurate diagnosis of periprosthetic joint infections (PJI) is one the most widely researched areas in modern orthopedic endoprosthesis. However, our understanding immunological basis this severe complication still limited. In study, we developed a flow cytometric approach to precisely characterize immune cell composition joints. Using high-dimensional multi-parametric data, defined, for first time, local populations artificial We identified significant differences cellular distribution...
Magnesium (Mg)-based implants have emerged as a promising alternative for orthopedic applications, owing to their bioactive properties and biodegradability. As the degrade, Mg
Profilin 4 (Pfn4) is expressed during spermiogenesis and localizes to the acrosome-acroplaxome-manchette complex. Here, we generated PFN4-deficient mice, with sperm displaying severe impairment in manchette formation. Interestingly, HOOK1 staining suggests that perinuclear ring established; however, ARL3 disrupted, suggesting lack of PFN4 does not interfere formation initial localization HOOK1, but impedes microtubular organization manchette. Furthermore, amorphous head shape flagellar...
Low expression levels of the E3 ubiquitin‑protein ligase Parkin (PARK2) are exhibited in several cancer entities, including clear cell renal carcinoma (ccRCC), and associated with poor prognosis; however, PARK2 can also function as a tumor suppressor gene. The aim present study was to thoroughly investigate effects overexpression ccRCC lines determine its on malignancy by conducting functional assays such cycle analysis, apoptosis migration invasion assays. Furthermore, liquid...
Abstract Protamines are the safeguards of paternal sperm genome. They replace most histones during spermiogenesis, resulting in DNA hypercondensation, thereby protecting its genome from environmental noxa. Impaired protamination has been linked to male infertility mice and humans many studies. Apart impaired integrity, protamine-deficient human murine show multiple secondary effects, including decreased motility aberrant head morphology. In this study, we use a Prm2 -deficient mouse model...
The last solar minimum has been unusually quiet compared to the previous minima (since space-based radiometric measurements are available). Sun's magnetic flux was substantially lower during this minimum. Some studies also show that total irradiance after cycle 23 may have dropped below values known from two prior that. For chromospheric and coronal radiation, situation is less clear-cut. 10.7\,cm shows a decrease of $\sim4\%$ in 2008 minimum, but \ion{Ca}{II} K does not. Here we consider...
Abstract Immune response genes are highly polymorphic in humans and mice, with heterogeneity amongst loci driving strain-specific host defense responses. The inadvertent retention of can introduce confounding phenotypes, leading to erroneous conclusions, impeding scientific advancement. In this study, we employ a combination RNAseq variant calling analyses identify substantial region 129S genome, including the Nlrp1 locus proximal Nlrp3 , one most commonly used mouse models NLRP3 deficiency....
Abstract Immune response genes are highly polymorphic in humans and mice, with heterogeneity amongst loci driving strain-specific host defense responses. The inadvertent retention of can introduce confounding phenotypes, leading to erroneous conclusions, impeding scientific advancement. In this study, we employ a combination RNAseq variant calling analyses identify substantial region 129S genome, including the Nlrp1 locus proximal Nlrp3 , one most commonly used mouse models NLRP3 deficiency....