Loss of photoreceptors in atrophic age-related macular degeneration results severe visual impairment, although some peripheral vision is retained. To restore central without compromising the residual field, we developed a wireless photovoltaic retinal implant (PRIMA; Pixium Vision, Paris, France) which pixels convert images projected from video glasses using near-infrared light into electric current to stimulate nearby inner neurons.We carried out first-in-human clinical trial test safety...

Abstract. Purpose: To investigate the clinical effects and safety of targeted pattern scan laser (Pascal) retinal photocoagulation (TRP) in proliferative diabetic retinopathy (PDR). Methods: Prospective non‐randomized study 28 eyes with treatment‐naive Single‐session 20‐ms‐Pascal TRP strategy applied 1500 burns to zones capillary non‐perfusion intermediate ischaemia guided by wide‐field fluorescein angiography (Optos). Main outcome measures at 12 24 weeks included; PDR grade (assessed two...

To assess the efficacy and safety of PRIMA neurostimulation system with a subretinal microchip for improving visual acuity (VA) in patients geographic atrophy (GA) due to age-related macular degeneration (AMD) at 48-months postimplantation.

<h3>Objective</h3> To investigate the effects of pattern scanning laser (Pascal; OptiMedica, Santa Clara, California) multispot panretinal photocoagulation given in a single-session (SS-PRP) vs single-spot multiple-session PRP (MS-PRP) on proliferative diabetic retinopathy (PDR). <h3>Methods</h3> Single-center, randomized clinical trial 40 eyes. Proliferative was treated with 400-μm spot size 1500 burns either as Pascal 20-millisecond SS-PRP or 3 sessions (100-millisecond MS-PRP) during...

<h3>Purpose</h3> To investigate the epidemiology and clinicopathological management for ocular sebaceous carcinoma (OSC) in UK. <h3>Methods</h3> Observational prospective cohort study of patients with newly-diagnosed OSC. The British Ophthalmological Surveillance Unit captured incident cases OSC between 2008 2010. Incident 6-month follow-up questionnaires from reporting ophthalmologists demographic clinical data. <h3>Results</h3> Data were available on 51 unilateral (response rate 85%). UK...

To analyse the complications and outcomes of vitrectomy surgery for endophthalmitis.This was a retrospective case series. All cases that underwent 23-gauge endophthalmitis at tertiary centre between 1 February 2013 2018 were included. Main outcome measures as follows: visual acuity (VA) final visit post-vitrectomy complications.33 patients included in study with 20 men 13 women, average age 63 years. post-surgical causes phacoemulsification (n=9), trabeculectomy (n=5), intravitreal injection...

Objectives: To compare in vivo burn morphologic features and healing responses of Pascal 20-and 100millisecond panretinal photocoagulation (PRP) burns proliferative diabetic retinopathy.Design: Prospective randomized controlled trial with 24 eyes assigned to either 20-or 100-millisecond PRP.Fundus autofluorescence Fourier domain optical coherence tomography (FD-OCT) were performed 1 hour 2 4 weeks after treatment.Main outcome measures included on FD-OCT greatest linear diameter (GLD) laser...

<h3>Purpose</h3> To investigate the short-term effects of high-density 20-ms laser on macular thickness using Pascal-targeted retinal photocoagulation (TRP) and reduced fluence/minimally-traumatic panretinal (MT-PRP) compared to standard-intensity PRP (SI-PRP) in proliferative diabetic retinopathy (PDR). <h3>Methods</h3> Prospective randomised clinical trial. Treatment-naive PDR was treated with single-session Pascal 2500 burns one three treatment arms (TRP:MT-PRP:SI-PRP). Primary outcome...

We report for the first time, to our knowledge, acquisition of noncontact ultra-wide-field oral fluorescein angiograms in premature infants with retinopathy prematurity.High-resolution were successfully obtained 3 consecutive prematurity at Oxford Eye Hospital, Oxford, England, using Optos Panoramic 200MA imaging system (Optos PLC).Noncontact captured angiographic provide a safe and alternative method evaluating retinal vasculature prematurity.

To report the evolution of pattern scanning laser (Pascal) photocoagulation burns in treatment diabetic retinopathy, using Fourier-domain optical coherence tomography (FD-OCT) and fundus autofluorescence (AF), to evaluate these characteristics with clinically visible alterations outer retina (OR) retinal pigment epithelium (RPE).Standard red-free colour photography (FP), FD-OCT, camera-based AF were performed 17 eyes 11 patients following macular panretinal (PRP).One hour Pascal application,...

To correlate in vivo spatial and spectral morphologic changes of short- to long-pulse 532 nm Nd:YAG retinal laser lesions using Fourier-domain optical coherence tomography (FD OCT), autofluorescence (AF), fluorescein angiography (FA), multispectral imaging.Ten eyes with treatment-naive preproliferative or proliferative diabetic retinopathy were studied. A titration grid burns at 20, 100, 200 milliseconds was applied the nasal retina fluence titrated produce four grades lesion visibility:...

<h3>Aim</h3> To describe the in vivo spatial and morphological vitreoretinal relationships associated with diabetic retinal neovascularisation using Fourier-domain optical coherence tomography (FD-OCT). <h3>Methods</h3> Qualitative assessment of macula, retina optic disc head FD-OCT (Topcon 3D OCT-1000) imaging patients treatment-naive laser-treated proliferative retinopathy (PDR). The morphology plane at (NVD) elsewhere (NVE) were examined, posterior vitreous evaluated. characteristics...