A5054968500- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Ethnobotanical and Medicinal Plants Studies
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Bioactive Compounds and Antitumor Agents
- Tryptophan and brain disorders
- Skin Protection and Aging
- Free Radicals and Antioxidants
- melanin and skin pigmentation
- Fungal Biology and Applications
- Toxin Mechanisms and Immunotoxins
- Alkaloids: synthesis and pharmacology
- Bioactive Natural Diterpenoids Research
- Amoebic Infections and Treatments
- Natural Compound Pharmacology Studies
- Genomics, phytochemicals, and oxidative stress
- Traditional and Medicinal Uses of Annonaceae
- Insect Pest Control Strategies
- Epigenetics and DNA Methylation
- Microbial Natural Products and Biosynthesis
- Plant Toxicity and Pharmacological Properties
- Phytochemistry and Bioactive Compounds
- Cynara cardunculus studies
Central University of Technology
2023-2025
Université de Yaoundé I
2014-2024
Onderstepoort Veterinary Academic Hospital
2017-2023
University of Pretoria
2017-2023
Martin Luther University Halle-Wittenberg
2021
National University of Sciences and Technology
2021
National University of Science and Technology
2021
Chinese Academy of Sciences
2018-2020
Chengdu Institute of Biology
2018-2020
Institut Pasteur
2014
Medicinal plants used for wound healing and skin diseases are key to unlocking the doors combating resistance of pathogens pharmaceuticals allopathic management. This study was aimed at screening antioxidant effects, anti-inflammatory activity capacity traditional medicinal in treatment conditions KwaZulu-Natal, South Africa. Eleven plant species were selected separated into different parts (bulbs, roots leaves) extracted using 50% aqueous methanol. The extracts assessed their nitric oxide...
Influenza infection remains a major health threat for animals and humans which crucially requires effective antiviral remedies. The usage of herbal medications as readily available alternatives their compatibility with the body fewer side effects compared to synthetic chemical treatments has become popular globally. aim this study was investigate screen in vitro anti-influenza activity extracts five South African medicinal plants, namely Tabernaemontana ventricosa, Cussonia spicata, Rapanea...
Free radicals have been implicated in the pathogenesis of diverse metabolic disorders including cancer. Therefore, fighting against free has become an important strategy prevention or treatment such diseases, addition to direct indirect anticancer chemotherapy. Sarcocephalus pobeguinii used traditionally treat various diseases which excess production is implicated, warranting investigation its radical scavenging, and anti-inflammatory activity.In present study, extracts from leaves, fruits,...
Oxidative stress is pivotal in the pathology of many diseases. This study investigated antioxidant phytochemistry avocado (Persea americana Mill.) peel. Different solvent extracts (dichloromethane, ethyl acetate, methanol, and water) peel were subjected to total phenol flavonoid quantification, as well vitro radical scavenging ferric reducing evaluation. The methanol extract was gradient column chromatographic fractionation. Fraction 8 (eluted with hexane:chloroform:methanol volume ratio...
Croton species (Euphorbiaceae) are distributed in different parts of the world, and used traditional medicine to treat various ailments including cancer, inflammation, parasitic infections oxidative stress related diseases. The present study aimed evaluate antioxidant, anti-inflammatory cytotoxic properties extracts from three species. Acetone, ethanol water leaf C. gratissimus, pseudopulchellus, sylvaticus were tested for their free radical scavenging activity. Anti-inflammatory activity...
Background:Sarcocephalus pobeguinii (Hua ex Pobég) is used in folk medicine to treat oxidative-stress related diseases, thereby warranting the investigation of its anticancer and anti-inflammatory properties. In our previous study, leaf extract S. induced significant cytotoxic effect against several cancerous cells with high selectivity indexes towards non-cancerous cells. Aim: The current study aims isolate natural compounds from pobeguinii, evaluate their cytotoxicity, effects as well...
According to a survey, the medicinal use of Androstachys johnsonii Prain is kept secret by traditional healers. Considering that inflammation and oxidative stress are major risk factors for progression various chronic diseases disorders, we resolved investigate antioxidant anti-inflammatory potentials A. using in vitro cell-based assays. The activity hydroethanolic leaf extract (AJHLE) was evaluated ABTS, DPPH, FRAP Its cytotoxic effect assessed on RAW 264.7 macrophages an MTT assay. Then,...
Buxus natalensis is recognized as a rich source of triterpenoidal alkaloids that are known to be effective in fighting different cancer types. Nevertheless, date, no anticancer potential B. extract has been yet described. Here, we investigated the antiproliferative activity leaf extracts on eight cell lines (MCF-7, 4T1, Caco-2, HeLa, A549, HepG2, DU145, and LNCaP). Chang liver line derived from normal tissue, was used control. hydroethanolic (BNHLE) found exert significant cytotoxic effect...
Leaves of Codiaeum variegatum ("garden croton") are used against bloody diarrhoea by local populations in Cameroon. This study aims to search for the active components from C. Entamoeba histolytica, and thereby initiate their mechanism action. A bioassay-guided screening aqueous extracts leaves various fractions was carried out trophozoites E. histolytica axenic culture. We found that anti-amoebic activity changed with respect collection criteria leaves. Thereby, optimal conditions were...
Drugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons are still not very clear. Interferon-α (IFN-α) is also used as a agent response rate low. It was found IFN-α could enhance cytotoxic effect of MEK inhibition. However, potential mechanisms unclear. Understanding cross-talk between and will help efficacy or inhibitors on cancer. Immunoprecipitation pull-down assay were to reveal formation signaling complex....
In southern Africa, many medicinal plants are used traditionally to treat gastrointestinal disorders and other infectious diseases. Newtonia hildebrandtii buchananii for the treatment of wounds skin conditions, an upset stomach. Following promising unpublished antibacterial activity against Escherichia coli, this study was undertaken evaluate potential efficacy N. extracts in treating diarrhoea. The antimicrobial determined a panel Gram-positive Gram-negative bacteria two fungi implicated...
Background: Sida rhombifolia (L) is a medicinal plant from tropical regions belonging to the Malvaceae family and plantea kingdom. It known for its multiple pharmacological properties. The aim of this work was evaluate anti-amoebic, anti-inflammatory potential aqueous ethanolic leaf stem extracts harvested in two localities Cameroon (Yaoundé Massangam Centre West regions, respectively). Methods: anti-amoebic activity evaluated on polyxenic culture Entamoeba histolytica. A primary macrophage...