A5057982299- Elasticity and Material Modeling
- Cellular Mechanics and Interactions
- Collagen: Extraction and Characterization
- Tendon Structure and Treatment
- 3D Printing in Biomedical Research
- Preterm Birth and Chorioamnionitis
- Orthopaedic implants and arthroplasty
- Pelvic floor disorders treatments
- Bone health and osteoporosis research
- Autoimmune Bullous Skin Diseases
- Spaceflight effects on biology
- Mechanical Engineering and Vibrations Research
- Vehicle Dynamics and Control Systems
- Connective tissue disorders research
- Pregnancy-related medical research
- Advanced Materials and Mechanics
- Reproductive System and Pregnancy
- Soil Mechanics and Vehicle Dynamics
- Platelet Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Ultrasound and Hyperthermia Applications
- Geophysics and Sensor Technology
- Biomedical and Engineering Education
- Nanofabrication and Lithography Techniques
- Advanced MEMS and NEMS Technologies
University of Nebraska–Lincoln
2024
University of Illinois Urbana-Champaign
2019-2024
Michigan State University
2024
University of Tehran
2014-2018
Collagen fibers in biological tissues have a complex 3D organization containing rich information linked to tissue mechanical properties and are affected by mutations that lead diseases. Quantitative assessment of this collagen fiber could help develop reliable biomechanical models understand structure-function relationships, which impact diagnosis treatment diseases or injuries. While there advanced techniques for imaging fibers, published methods quantifying been sparse give limited...
The structural and mechanical properties of tissue the interplay between them play a critical role in function. We introduce optomechanogram, combined quantitative qualitative visualization spatially co-registered measurements microstructural micromechanical any tissue. Our approach relies on co-registration two independent platforms, second-harmonic generation (SHG) microscopy for assessment 3D collagen-fiber organization, nanoindentation (NI) local properties. experimentally validate our...
Binding of autoantibodies to keratinocyte surface antigens, primarily desmoglein 3 (Dsg3) the desmosomal complex, leads dissociation cell-cell adhesion in blistering disorder pemphigus vulgaris (PV). After initial disassembly desmosomes, adhesions actively remodel association with cytoskeleton and focal adhesions. Growing evidence highlights role mechanics mechanotransduction at this remodeling process, as their active participation may direct autoimmune pathogenicity. However, a large part...
Conceptual modelling is known as a well suited alternative approach for Computer-Aided Engineering (CAE) analysis in automotive industry.In this paper, an improved conceptual method which beams and panels of the structure are modelled simplified beam elements has been proposed.To explore advantage modeling determining resonant frequencies/mode-shapes, case study wheelhouse was performed.Firstly, experimental test advanced CAE were carried out to measure dynamic characteristics.The model then...
Epithelial cells experience long lasting loads of different magnitudes and rates. How they adapt to these strongly impacts tissue health. Yet, much remains unknown about the evolution cellular stress in response sustained strain. Here, by subjecting cell pairs strain, we report a bimodal response, where addition typically observed relaxation, subset exhibits dynamic tensioning process with significant elevation within 100s, resembling active pulling-back muscle fibers. Strikingly, fraction...
Gyroscopes are used as rotation rate sensors. Conventional gyroscopes heavy and bulky, which creates important problems regarding their usage in different applications. Micro-gyroscopes have solved these due to small size. The beam micro-gyroscope is one of the popular types inertial Their dimensions low energy consumption key reasons for popularity. In this investigation, model an electrostatically actuated beam-based study effect design parameters on pull-in voltage fundamental frequency....
Developing precise computational models of bone remodeling can lead to more successful types orthopedic treatments and deeper understanding the phenomenon. Empirical evidence has shown that adaptation mechanical loading is frequency dependent modal behavior under vibration play a significant role in process, particularly resonance region. The objective this study develop algorithm takes into account effects vibrational behavior. An extended/modified model presented based on conventional FE...
Understanding the molecular and physical complexity of tissue microenvironment (TiME) in context its spatiotemporal organization has remained an enduring challenge. Recent advances engineering data science are now promising ability to study structure, functions, dynamics TiME unprecedented detail; however, many still occur silos that rarely integrate information full detail. This review provides integrative overview principles underlying chemical, optical, electrical, mechanical,...
<title>Abstract</title> Epithelial cells experience long lasting loads of different magnitudes and rates. How they adapt to these strongly impacts tissue health. Yet, much remains unknown about their stress evolution under sustained strain. Here, by subjecting cell pairs strain, we report a bimodal response, where in addition the typically observed relaxation, subset exhibits dynamic tensioning process with significant elevation within 100s, resembling active pulling-back muscle fibers....
To guide development and optimization of dMRI protocols, here we present a numerical simulation framework for analyzing how changes in collagen microstructure influence the measured diffusion tensor. We experimentally characterize porcine digital flexor tendon using second harmonic generation (SHG) microscopy to identify characteristic geometric parameters use these parameter ranges perform sensitivity analysis what microstructural features most tensor imaging (DTI) metrics. conclude by...
Pemphigus vulgaris (PV) is a blistering autoimmune disease that affects the skin and mucous membranes. The precise mechanisms by which PV antibodies induce complete loss of cohesion keratinocytes are not fully understood. But it accepted process starts with antibody binding to desmosomal targets leads its disassembly subsequent structural changes cell-cell adhesions. In vitro immunofluorescence imaging desmosome molecules has been used characterize this initial phase, often qualitatively....
We quantitatively analyze non-pregnant rat cervix on three distinct regions using second-harmonic generation imaging. 3D structural parameters related to collagen organization are obtained each region respectively.
The cervix acts as a dynamic barrier between the uterus and vagina, retaining fetus during pregnancy allowing birth at term. Critical to this function, physical properties of change, or remodel, but dysfunctional remodeling can lead preterm (PTB). Although cervical has been studied, complex 3D microstructure not well-characterized. In complex, dynamic, heterogeneous tissue microenvironment, microstructural changes are likely also heterogeneous. Using quantitative, 3D, second-harmonic...
The spatial arrangement and interactions of the extracellular matrix (ECM) components control mechanical behavior tissue at multiple length scales. Changes in microscale deformation mechanisms affect function are often hallmarks remodeling disease. Despite their importance, that modulate collagenous tissue, particularly indentation compression modes deformation, remain poorly understood. Here, we develop an integrated computational experimental approach to investigate microscale. While...
Microscale deformation processes, such as reorientation, buckling, and sliding of collagen fibrils, determine the mechanical behavior function collagenous tissue. While changes in structure composition tendon have been extensively studied, mechanisms that modulate interaction extracellular matrix (ECM) constituents are not well understood, partly due to lack appropriate techniques probe behavior. In particular, role glycosaminoglycans (GAGs) modulating fibril interactions has remained...