A5032890386- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Crystallography and molecular interactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Oxidative Organic Chemistry Reactions
- Phytochemical compounds biological activities
- Biochemical and Molecular Research
- Cyclopropane Reaction Mechanisms
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Reactions
- Electrowetting and Microfluidic Technologies
- Coordination Chemistry and Organometallics
- Catalytic Processes in Materials Science
- Chemistry and Chemical Engineering
- Microfluidic and Capillary Electrophoresis Applications
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Macrophage Migration Inhibitory Factor
AstraZeneca (United Kingdom)
2006-2024
AstraZeneca (Brazil)
2018
Macclesfield College
2018
University of Oxford
2006-2015
Syngenta (United Kingdom)
2006
Merck & Co., Inc., Rahway, NJ, USA (United States)
2003-2004
The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg product 24 h. other had productivities 4 8 consists succession quartz tubes connected together series arranged axially around variable mercury lamp. This relatively simple device can be safely operated standard fumehood.
[reaction: see text] The palladium-catalyzed coupling of a range enol triflates with amides, carbamates, and sulfonamides has been developed. This offers simple widely applicable synthesis enamides, which may not be readily available by other means.
The use of N-sulfonyloxy carbamates as reoxidants for the tethered aminohydroxylation (TA) reaction is reported. These new conditions obviate requirement lithium hydroxide and tBuOCl in oxidation mixture. In addition to providing products good yields, catalyst loadings can be reduced just 1 mol % osmium. Moreover, first time, homoallylic alcohols are now viable substrates TA reaction.
ω-Transaminase enzyme chemistry provides an excellent methodology to build synthetically useful chiral amines from their corresponding ketones. An application of this methodology, providing a long-term commercial manufacturing route JAK2 kinase inhibitor, is reported herein.
Electrochemical deprotection of p-methoxybenzyl (PMB) ethers was performed in an undivided electrochemical flow reactor MeOH solution, leading to the unmasked alcohol and p-methoxybenzaldehyde dimethyl acetal as a byproduct. The method removes need for chemical oxidants, added electrolyte (BF4NEt4) can be recovered reused. applied 17 substrates with high conversions single pass, yields up 92%, 7.5 g h–1 productivity. PMB protecting group also selectively removed presence some other common groups.
A simple method for the accurate calculation of optimal flow rates photochemical reactions from optimized batch results is described and demonstrated in scale-up three challenging examples.
A range of enantiopure polyhydroxylated piperidines, including (2R,3S,4R)-dihydroxypipecolic acid, (-)-3-epi-fagomine, (2S,3S,4R)-dihydroxyhomopipecolic (2S,3R,4R)-dihydroxyhomopipecolic and two trihydroxy-substituted homopipecolic acids, have been prepared using diastereoselective olefinic oxidations a tetrahydropyridines as the key step. The requisite substrates were readily from tert-butyl sorbate our hydroamination or aminohydroxylation protocols followed by ring-closing metathesis....
An efficient route to AZD4635 has been developed utilizing the Suzuki–Miyaura reaction of a boronate ester prepared by C–H borylation on multikilogram scale. Preparation cross-coupling partner using bromine/pyridine/methanol highlighted incompatibility this reagent/solvent combination with tantalum, which is commonly used in construction and repair standard manufacturing vessels.
The AstraZeneca approach to synthetic Route Design is exemplified through our AZD4635 chemical development program. identification of possible new route concepts presented, as well their subsequent prioritization for practical exploration based on project objectives. Selected ideas were tested demonstrate proof concept the bond formation strategy and, where successful, fed into a decision tool key SELECTion principles.
The sealutomicins are a family of anthraquinone antibiotics featuring an enediyne (sealutomicin A) or Bergman-cyclized aromatic ring (sealutomicins B – D). Herein we report the development enantioselective organocatalytic method for synthesis dihydroquinolines and use developed in total sealutomicin C which features transannular cyclization aryl lithium onto gamma-lactone as second key step.
The sealutomicins are a family of anthraquinone antibiotics featuring an enediyne (sealutomicin A) or Bergman-cyclized aromatic ring (sealutomicins B–D). Herein we report the development enantioselective organocatalytic method for synthesis dihydroquinolines and use developed in total sealutomicin C which features transannular cyclization aryllithium onto γ-lactone as second key step.
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Abstract The target compounds are synthesized using diastereoselective olefinic oxidations of enantiopure tetrahydropyridines.