A5047183435- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Advanced Neuroimaging Techniques and Applications
- Infection Control and Ventilation
- COVID-19 epidemiological studies
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Vaccine Coverage and Hesitancy
- Metabolism and Genetic Disorders
- Geriatric Care and Nursing Homes
- Tuberculosis Research and Epidemiology
- COVID-19 and healthcare impacts
- Nuclear Receptors and Signaling
- Employment and Welfare Studies
- Transplantation: Methods and Outcomes
- Opioid Use Disorder Treatment
- Organ Transplantation Techniques and Outcomes
- Biochemical effects in animals
- Traumatic Brain Injury Research
- Food Security and Health in Diverse Populations
- Primary Care and Health Outcomes
- Homelessness and Social Issues
- COVID-19 Clinical Research Studies
- Climate Change and Health Impacts
- Travel-related health issues
University of Illinois Chicago
2018-2025
Chicago Department of Public Health
2022-2025
Centers for Disease Control and Prevention
2024
NorthShore University HealthSystem
2011-2019
Illinois Department of Public Health
2019
the Chicago Department of Public Health (CDPH) was notified a potential outbreak coronavirus disease 2019 (COVID-19) at an exercise facility.COVID-19 cases were identified among 55 (68%) 81 attendees in-person classes held during August 24-September 1, 2020, including 49 (60%) confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR) testing and six (7%) probable who had compatible symptoms but negative or no RT-PCR test results.Overall, 43 (78%) with COVID-19...
ABSTRACT BACKGROUND Occupation, a risk factor for SARS-CoV-2 exposure, is excluded from immunization records. Identifying under-vaccinated workers could optimize interventions to protect vulnerable populations. METHODS We analyzed health department case interviews (June 2021-May 2022) describe 3,763 non-health care with COVID-19 in Chicago. Job exposure matrices categorized through frequency of indoor work, proximity the public and coworkers. Logistic regression quantified associations...
Abstract The pre‐transplant weight loss required of end‐stage renal disease patients is often unachievable. Though robot‐assisted procedures among extremely obese have shown minimal complication, long‐term outcomes are understudied. Previously, we reported no difference in 6‐month patient and graft survival 28 transplant cases (2009‐2013) open controls (2004‐2010). Groups were frequency‐matched on age, sex, race, donor compatibility, disease, dialysis history. Cases had greater median body...
Objectives: Early in the COVID-19 pandemic, several outbreaks were linked with facilities employing essential workers, such as long-term care and meat poultry processing facilities. However, timely national data on which workplace settings experiencing unavailable through routine surveillance systems. We estimated number of US identified types they occurred during August–October 2021. Methods: The Centers for Disease Control Prevention collected from health departments August October 2021:...
While frontline and essential workers were prioritized for COVID-19 vaccination in the United States, coverage rates encouragement strategies among non-health care have not been well-described. The Chicago Department of Public Health surveyed businesses to fill these knowledge gaps identify potential mechanisms improving vaccine uptake.The Workplace Encouragement Vaccination survey (WEVax Chicago) was administered using REDCap from July 11 September 12, 2022, previously contacted...
Mild traumatic brain injury (TBI) is an important public health problem generated by closed head injury. This study focused on the impact of blast-induced mild TBI auditory trace and delay fear conditioning, models declarative non-declarative memory, respectively, correlation conditioned freezing fractional anisotropy, a measure axonal state. A supersonic helium pressure wave was shock tube to blast 8-week-old male mice Day 1 for 1.4 msec with incident 16 psi, corresponding reflected 56.9...
To describe COVID-19 investigations by a large urban health department among non-health care, noncongregate workplaces and the utility of surveillance methods over time.Frequencies workplace-associated clusters outbreaks are described workplace type, workforce size, method identification time.From April 2020 through January 2022, 496 identified 442 (89%) 54 (11%). Frontline essential comprised 36% before versus 15% after vaccine eligibility. Pre-Omicron, most (84%) were case interviews....
Abstract There are limited real‐world data on the effectiveness of tixagevimab‐cilgavimab as pre‐exposure prophylaxis COVID‐19. We describe lessons learned when coordinating collection and identifying breakthrough SARS‐CoV‐2 infections among patients across indications institutions in a major US city. The Chicago Department Public Health requested patient‐level administration from all prescribing providers Chicago, for treatments December 8, 2021 through June 30, 2022. Records were matched...
Objectives. To compare the incidence, case-hospitalization rates, and vaccination rates of COVID-19 between people experiencing sheltered homelessness (PESH) broader community in Chicago, Illinois, describe impact a whole approach to disease mitigation during public health emergency. Methods. Incidence among PESH was compared with community-wide incidence using case-based surveillance data from March 1, 2020, May 11, 2023. Seven-day rolling means were assessed for overall study period each 6...
ObjectiveTo evaluate capacity of the BioSense ESSENCE platform and pre-defined overdose queries to identify emergency department admissions related opioid overdose, in compliance with 2018 mandatory reporting laws IllinoisIntroductionAccuracy identifying drug-related is critical understanding local burden disease assessing effectiveness drug abuse prevention overdose-reduction initiatives. In Illinois Department Public Health (IDPH) began implementation a law, applicable all hospital...
High resolution MRI has been used previously to examine cortical and hippocampal atrophy in mouse models of AD. We report here a novel alteration MR contrast specifically the CA1 pyramidal cell layer (CA1py) transgenic that coexpresses five FAD mutations. 5xFAD mice (Tg) coexpressing 3 APP 2 PS1 mutations littermate wildtype (WT) controls were used. Fixed brains from 2, 4 10M old imaged at14.1T. T relaxation time maps obtained using TR 6000ms, TE 7.5ms, 16 echoes, slice thickness 0.3mm,...
High resolution MRI has been used previously to examine cortical and hippocampal atrophy in mouse models of AD. We report here a novel alteration MR contrast specifically the CA1 pyramidal cell layer (CA1py) transgenic that coexpresses five FAD mutations. 5xFAD mice (Tg) coexpressing 3 APP 2 PS1 mutations littermate wildtype (WT) controls were used. Fixed brains from 2, 4 10M old imaged at14.1T. T relaxation time maps obtained using TR 6000ms, TE 7.5ms, 16 echoes, slice thickness 0.3mm,...
The neuropathological effects of AD on each the interconnected subfields hippocampal region need to be better characterized using neuroimaging techniques improve its diagnosis based imaging biomarkers. Using high resolution diffusion tensor (DTI) we have investigated cytoarchitecture hippocampus in a transgenic mouse model AD, and found layer-specific alterations anisotropy within dentate gyrus (DG) CA1 at different stages pathology. Female 5xFAD mice coexpressing total five FAD mutations [3...
Presenilins play essential roles ranging from embryonic development to apoptosis. Early onset familial AD has been associated with mutations in the genes encoding presenilins (PS1 and PS2). The mechanism by which PS1 PS2 promote neurodegeneration is still under investigation. We have used high spatial resolution MR imaging investigate morphological alterations brains of mice was deleted conventional methods selectively adult forebrain using Cre/loxP (Feng R et al. Neuron 32: 911–926, 2001)....
Presenilins play essential roles ranging from embryonic development to apoptosis. Early onset familial AD has been associated with mutations in the genes encoding presenilins (PS1 and PS2). The mechanism by which PS1 PS2 promote neurodegeneration is still under investigation. We have used high spatial resolution MR imaging investigate morphological alterations brains of mice was deleted conventional methods selectively adult forebrain using Cre/loxP (Feng R et al. Neuron 32: 911–926, 2001)....
The neuropathological effects of Alzheimer's disease (AD) on each the interconnected subfields hippocampal region need to be better characterized using neuroimaging techniques improve its diagnosis based imaging biomarkers. Using high resolution diffusion tensor (DTI) we have investigated cytoarchitecture hippocampus in a transgenic mouse model AD, and found layer-specific alterations anisotropy within dentate gyrus (DG) CA1 at different stages pathology. Female 5xFAD mice coexpressing total...
Abstract Background While frontline and essential workers were prioritized for COVID-19 vaccination in the United States, coverage rates encouragement strategies among non-healthcare have not been well-described. The Chicago Department of Public Health surveyed businesses to fill these knowledge gaps identify potential mechanisms improving vaccine uptake. Methods Workplace Encouragement Vaccination survey (WEVax Chicago) was administered, using REDCap from July 11 September 12, 2022,...
Dentate gyrus volume loss has been reported as an early pathological change in the PDAPP mouse model of AD. Using diffusion tensor imaging (DTI) we have investigated cytoarchitectural alterations laminar regions dorsal hippocampus 5xFAD transgenic (Tg) We find age-dependent decrease anisotropy which suggests dendritic abnormalities molecular layer dentate mice. Female Tg mice co-expressing five FAD mutations [3 APP + 2 PS1] were used. Age-matched littermate wildtype (WT) used controls. Mice,...
Diffusion tensor imaging (DTI) is an MR method that can provide novel microstructural information about the brain tissue based on anisotropy of water diffusion. We have used high spatial resolution DTI to investigate cytoarchitectural alterations in laminar regions dorsal hippocampus APP transgenic (Tg) mouse model AD. find age-dependent decrease diffusion molecular layer dentate gyrus Tg mice. Female 5xFAD mice co-expressing five FAD mutations [3 + 2 PS1] were used. Age-matched littermate...