A5013304167- Cancer-related Molecular Pathways
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Bone Metabolism and Diseases
- Bone health and treatments
- RNA modifications and cancer
- Health and Well-being Studies
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Ophthalmology and Visual Health Research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone Tumor Diagnosis and Treatments
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Sarcoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Health Promotion and Cardiovascular Prevention
- School Health and Nursing Education
- Viral Infectious Diseases and Gene Expression in Insects
- Global Public Health Policies and Epidemiology
The University of Texas MD Anderson Cancer Center
2017-2025
Scripps MD Anderson Cancer Center
2023
The University of Texas Health Science Center at Houston
2023
Brown Foundation
2016
KU Leuven
2007-2011
Tehran University of Medical Sciences
2005-2010
Shariati Hospital
2003-2006
University of Tehran
2003-2006
TP53 mutation (TP53mut ) confers an adverse prognosis in acute myeloid leukemia (AML). Venetoclax with hypomethylating agents is a current standard for older patients; however, recent reports suggest that TP53mut resistance to venetoclax. The authors investigated the outcomes of patients AML who were treated 10-day decitabine and venetoclax (DEC10-VEN) (ClinicalTrials.gov identifier NCT03404193).Patients newly diagnosed received 20 mg/m2 10 days every 4 6 weeks induction, followed by 5 after...
The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but etiology is still unclear. Here, we report a novel function for as regulator of β-catenin·TCF4-mediated transcription. We show that can bind directly to DNA-binding high mobility group box TCF4 via its zinc finger domain and inhibit transcriptional activity β-catenin·TCF4 complex. However, binding DNA was not affected by ZIC2. Zic2 RNA...
TP53 is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but mechanisms mediating these functions remain poorly defined vivo. To elucidate how GOF drives we developed a traceable somatic osteosarcoma mouse model initiated with either single mutation (p53R172H) or loss osteoblasts. Our study confirmed mice osteosarcomas increased metastasis as compared -null mice. Comprehensive...
In TP53 wild-type acute myeloid leukemia (AML), inhibition of MDM2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. inhibitor (MDM2i) monotherapy in AML has shown modest responses clinical trials but combining options MDM2i with other potent AML-directed agents like cytarabine venetoclax could improve its efficacy. We conducted a phase I trial (NCT03634228) to study the safety efficacy milademetan (an MDM2i) low-dose (LDAC)±venetoclax adult patients relapsed...
Elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of the inadequate vitamin B12 folate insufficiency. Folate have protective effect on disease. This population based study was conducted to evaluate homocysteine, folate, in healthy Iranian individuals.This part Cardiovascular Risk Factors Survey Population Lab Region Tehran University has been designed methodology MONICA/WHO Project. A 1214 people aged 25-64 years, were...
The investigation of the mechanisms behind p53 mutations in acute myeloid leukemia (AML) has been limited by lack suitable mouse models, which historically have resulted lymphoma rather than leukemia. This study introduces two new AML models. One model induces mutant and Mdm2 haploinsufficiency early development, showing role myeloid-biased hematopoiesis predisposition, independent p53. second mimics clonal inducing adult hematopoietic stem cells, demonstrating that timing mutation...
Abstract Therapy-related myeloid neoplasms (t-MNs) are devastating complications arising from cancer chemotherapy, particularly affecting patients treated with agents like alkylating and platinum compounds. TP53 mutations the most frequent genetic alterations in t-MNs, present 25-40% of cases. While selective expansion p53-mutant HSCs under chemotherapeutic pressure, known as clonal hematopoiesis (CH), has been implicated t-MN development, transition to malignant transformation remains...
Background: Metabolic syndrome includes obesity, hypertriglyceridemia, glucose intolerance, hypertension, and lipid profile abnormalities. The risk of cardiovascular diseases with this is higher than each its components alone. Currently, disorders have a great burden high mortality rate in Iran. This study was performed to determine prevalence the metabolic underlying an urban population Tehran. Methods: 25–64-year-old individuals Population Laboratory Tehran University Medical Sciences were...
Abstract Background: Obesity is a growing public health problem in developing countries considering its association with cardiovascular risk factors. Relationship between childhood obesity and these factors has not been attested the Iranian population before. The aim of present study was to investigate frequency their severity sample obese children. Methods: A total 13 086 children aged 7–12 years were screened those waist circumference = 90th percentile age invited for further evaluations....
RNA and protein analysis revealed the consistent upregulation of neural transcription factors ZIC1 ZIC4 in desmoid tumors other fibroproliferative disorders. The 5′ flanking region promoter was unmethylated tumor fibroblasts, while a hypermethylated found human mouse cell lines not expressing gene. In addition, cells showed H3K4me2 at promoter, whereas non‐expressing higher levels H3K9me2 same region. To our knowledge, this is first report describing expression mesenchymal proliferations...
Abstract Background Ewing sarcoma is a malignancy of primitive cells, possibly mesenchymal origin. It probable that genetic perturbations other than EWS-FLI1 cooperate with it to produce the tumor. Sequencing studies identified STAG2 mutations in approximately 15% cases humans. In present study, we hypothesize loss Stag2 cooperates generating sarcomas derived from murine stem cells (MSCs). Methods Mice bearing an inducible transgene were crossed p53 −/− mice pure C57/Bl6 background. MSCs...
Abstract Despite effective new therapies, adaptive resistance remains the main obstacle in acute myelogenous leukemia (AML) therapy. Autophagy induction is a key mechanism for resistance. Leukemic blasts at diagnosis express higher levels of apical autophagy kinase ULK1 compared with normal hematopoietic cells. Exposure to chemotherapy and targeted agents upregulate ULK1, hence we hypothesize that developing inhibitors may present unique opportunity clinical translation inhibition....
Abstract Missense mutations in the DNA binding domain of p53 are characterized as structural or contact based on their effect conformation protein. These show gain-of-function (GOF) activities, such promoting increased metastatic incidence compared with loss, often mediated by interaction mutant a set transcription factors. interactions largely context specific. To understand mechanisms which drive osteosarcoma progression, we created mouse models, either p53R172H p53R245W expressed...
Insulin resistance syndrome is a cluster of metabolic abnormalities that accompanied with an increased risk diabetes and cardiovascular diseases. This has become important problem in urban children due to their increasing levels obesity. A total 535 obese 7–11- year-old students all the primary schools 6th district Tehran were screened according waist circumference then confirmed International Obesity Task Force (IOTF) criteria. Waist circumference, fasting serum triglycerides, high-density...
To estimate the direct cost of coronary heart disease [CHD] to Iranian oil industry, we calculated essential services for 1253 CHD patients admitted National Oil Corporation [NIOC] Central Hospital. The at Hospital was 10940 million rials [US$ 1 = 8000 rials], or 8.7 per patient. industry estimated 22 770 rials. Working days lost workers hospitalized amounted 62 832. heavy burden on necessitates introduction an industry-wide prevention programme
BackgroundA parental history of cardiovascular disease has a strong relationship with risk factor clusters in the offspring. This study was performed to identify major factors middle school-aged children and their parents both high low-risk families.
Abstract Mesenchymal stromal cells (MSCs) are a key component of the bone marrow (BM) niche, providing essential support required for maintenance hematopoietic stem cells. To advance our understanding physiological functions p53 and Mdm2 in BM-MSCs, we developed traceable conditional mouse models targeting and/or Trp53 vivo. We demonstrate that is emergence, maintenance, BM-MSCs. haploinsufficiency BM-MSCs resulted genotoxic stress–associated thrombocytopenia, suggesting functional role...
<div>Abstract<p>Missense mutations in the DNA binding domain of p53 are characterized as structural or contact based on their effect conformation protein. These show gain-of-function activities, such promoting increased metastatic incidence compared to loss, often mediated by interaction mutant with a set transcription factors. interactions largely context specific. In order understand mechanisms which drive osteosarcoma progression, we created mouse models, either p53R172H...