A5087101860- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Frailty in Older Adults
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatitis Viruses Studies and Epidemiology
- Bone Metabolism and Diseases
- Bacterial Infections and Vaccines
- High Altitude and Hypoxia
- SARS-CoV-2 detection and testing
- Nuclear reactor physics and engineering
- Pneumocystis jirovecii pneumonia detection and treatment
- Animal Virus Infections Studies
- Liver physiology and pathology
- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Nuclear Physics and Applications
- Macrophage Migration Inhibitory Factor
- Sepsis Diagnosis and Treatment
Stanford University
2025
University of Sheffield
2020-2024
Imperial College London
2022-2024
University of Oxford
2023
Restore America's Estuaries
2023
Newcastle University
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Collaborative Group (United States)
2023
NIHR Leicester Biomedical Research Centre
2023
University of Leicester
2023
To determine whether global reduction of CD68 (cluster differentiation) macrophages impacts the development experimental pulmonary arterial hypertension (PAH) and this affects balance pro- anti-inflammatory within lung. Additionally, to there is evidence an altered macrophage polarization in patients with PAH. Approach Results: Macrophage was induced mice via doxycycline-induced CD68-driven cytotoxic diphtheria toxin A chain expression (macrophage low [MacLow] mice). Chimeric were generated...
Reduced oxygen tensions experienced at high altitudes are thought to predispose thrombosis, yet there few studies linking hypoxia, platelet activation, and thrombosis. Reports of phenotypes in hypoxia inconsistent, perhaps due differing degrees the duration exposure. This study aimed investigate relationship between soluble P-selectin, a marker von Willebrand factor (vWF) on exposure hypoxia. We measured plasma concentrations P-selectin vWF sixteen healthy volunteers before, during after...
Background: Pulmonary arterial hypertension (PAH) is a severe condition characterized by pulmonary vascular remodelling leading to right ventricle failure. Emerging evidence highlights inflammation as crucial pathogenic factor of PAH. Members the complement pathway have been identified dysregulated in multiple studies. We aimed investigate relative contribution different components PAH pathogenesis using pre-clinical rodent models. Methods and Results: The Sugen 5416 (20 mg/kg, i.p.) plus...
<b>Introduction:</b> Calprotectin (S100A8/A9), an antimicrobial complex released by activated neutrophils, is significantly elevated in bacterial pneumonia and correlates with COVID19 severity. <b>Aim:</b> Evaluate the ability of a commercial, quantitative serum calprotectin lateral flow test (LFT) to predict clinical outcomes identify neutrophil hyperactivation acute lung infection. <b>Methods:</b> Serum was measured LFT ELISA patients hospitalised SARS-CoV-2 infection, non-COVID lower...
<b>Introduction:</b> Inflammation is associated with the development of pulmonary vascular remodelling in arterial hypertension (PAH). While some viral pathogens have been implicated PAH, we do not know if prior activation antiviral immunity lungs an important driver disease. <b>Aim:</b> To investigate lung inflammation induced by double-stranded RNA, activator immunity, alters severity (PH) sugen-hypoxia (SuHx) mouse model PH. <b>Methods:</b> C57BL/6J mice were administered single or...
<b>Introduction:</b> COVID19 can cause profound systemic inflammation. Understanding inflammation and immune cell function may allow prediction of outcomes, longer-term effects identification further therapeutic targets. <b>Methods:</b> Prospective observational study of patients with PCR-confirmed SARS-CoV-2 enrolled within 96 hours admission at two UK hospitals(May2020–March2021), longitudinal sampling up to 29 days. mRNAseq was performed in peripheral blood cells, 45 serum...