The gut microbiome has been linked to cognitive function and appears worsen with aging. Probiotic supplementation found improve the health of microbiome. As such, it is possible that probiotic may protect aging brain. current study examined benefits (Lactobacillus rhamnosus GG) in healthy middle-aged older adults.The was a double-blind, placebo-controlled, randomized clinical trial. Two hundred community-dwelling adults aged 52-75 were enrolled (mean age=64.3, SD=5.52). A three-month...

BACKGROUND: Alzheimer’s disease and related dementias are irreversible, progressive brain disorders that slowly destroy memory, language, problem solving, cognition. In the United States, dementia is fifth leading cause of death for people age 65 years older. Early diagnosis could have important benefits stigma to remains a significant impediment diagnosis, treatment, accessing services. While growing body research documents existence negative outcomes stigma, less known about how...

ABSTRACT Disturbances in the gut microbiome is increasing correlated with neurodegenerative disorders, including Alzheimer’s Disease. The may fact influence disease pathology AD by triggering or potentiating systemic and neuroinflammation, thereby driving along “microbiota-gut-brain-axis”. Currently, drivers of cognitive decline symptomatic progression remain unknown understudied. Changes composition offer clues to potential physiologic neuropathologic changes that contribute decline. Here,...

Cognitive impairment is common in persons with opioid use disorder and associated poor treatment outcomes, including elevated risk for relapse. Much less known about the underlying structure of these deficits possible presence cognitive phenotypes. A total 177 adults (average 42.2 years age, 52.0% male, 65.5% Caucasian) enrolled a methadone maintenance program completed NIH Toolbox as part larger project. Cluster analyses revealed 2-cluster solution–persons intact function all domains (n =...

Cognitive decline is common in older adults and more than 5 million Americans suffer from Alzheimer's disease (AD). A number of physiological processes including systemic inflammation, excess adiposity, impaired glucoregulation arise a combination genetic behavioral factors increase risk for developing AD or other forms dementia. Recent research suggests that the gut microbiome may moderate these pathological possibly influence cognitive outcomes. This paper reviews methodology double-blind,...

Anxiety and depressive symptoms are prevalent in athletes. The pandemic of novel coronavirus (COVID-19) may increase risk for due to fear exposure during competition or uncertainty regarding participation. current study examined the prevalence COVID-19 anxiety 437 National Collegiate Athletic Association Division I student-athletes its association with psychological symptoms. Only 0.2% participants endorsed above cutoff. did not change after postponement fall sports differ between persons...

The population of older adults is growing dramatically and, with it comes increased prevalence neurological disorders, including Alzheimer's disease (AD). Though existing cognitive screening tests can aid early detection decline, these methods are limited in their sensitivity and require trained administrators. current study sought to determine whether possible identify persons mild impairment (MCI) using automated analysis spontaneous speech. Participants completed a brief...

There is growing interest in the pathophysiological processes of preclinical Alzheimer's disease (AD), including potential role leptin. Human studies have shown that both low and high levels leptin can be associated with worse neurocognitive outcomes, suggesting this relationship may moderated by another risk factor. We examined association between plasma neuropsychological test performance structural neuroimaging assessed whether body mass index (BMI) an effect modifier these associations....

The prevalence of dementia is projected to increase with the growing older adult population and prevention strategies are urgently needed. Two promising interventions include physical activity (PA) probiotic supplementation, initial findings suggesting their combined use may confer greater cognitive benefits than either intervention alone. However, no study has yet examined effects supplementation on function in healthy, physically active adults. present used archival data from a randomized...

The current study examined the association between subjective cognitive dysfunction and objective test performance in persons enrolled drug treatment stabilized on methadone maintenance therapy (MMT). A total of 177 participants completed self-reported brief inventory neurocognitive impairment (BINI) NIH Toolbox battery. In with dysfunction, scores all BINI subscales were negatively associated (BINI Global r = −0.26, p 0.01; Subscales ranging −0.22 to −0.32, p's < 0.03). Using cutoff scores,...

Background Neurocognitive dysfunction is common among individuals with opioid use disorders (OUD) and can impede a range of treatment outcomes. We developed the 57-item Brief Inventory Neuro-cognitive Impairment (BINI) to help detect monitor neurocognitive in context drug settings. To date, no study has examined possible presence BINI subgroups OUD patients, which could enhance our ability tailor intervention strategies meet individual needs. The purpose this was conduct latent profile...

Abstract Background Speech analysis data are promising digital biomarkers for the early detection of Alzheimer disease. However, despite its importance, very few studies in this area have examined whether older adults produce spontaneous speech with characteristics that sufficiently consistent to be used as proxy markers cognitive status. Objective This preliminary study seeks investigate consistency across lexical and without impairment. Methods A total 39 from a larger, ongoing (age: mean...

To examine whether pre-season assessment using a validated tool, the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), could predict college student-athletes identified as experiencing in-season mental health (MH) problems.A prospective study of athletes who completed evaluation in August 2018.A total 195 National Collegiate Athletic Association Division 1 from large midwestern university northeast Ohio.The MMPI-2-RF, 338-item self-report measure constructs...

Cognitive functioning may account for minimal levels (i.e., 5%-14%) of variance performance validity test (PVT) scores in clinical examinees. The present study extended this research twofold: (a) by determining the cognitive explains within three distinct PVTs (b) a sample patients with multiple sclerosis (pwMS). Seventy-five pwMS (

Abstract Background It has been shown that dysbiosis, or dysfunction of the gastrointestinal (gut) microbiome is associated with Alzheimer’s disease (AD). Here, we aimed to expand on beyond our previously reported findings gut associating AD and explore if predictive cognitive performance in individuals AD. We sought identity what domains are cohort patients healthy controls without dementia. Method Older residing general community central Massachusetts were enrolled study. At each visit,...

Functional gastrointestinal disorders such as irritable bowel syndrome are often associated with abdominal discomfort, bloating, and cramping. There is growing evidence that symptoms also related to cognitive function, but this association has not been previously examined in young adults.We cross-sectional relationships between nonspecific cognition 56 healthy adults (41 female, 15 male) without diagnosis of disorder.Gastrointestinal were poorer performance on objective tests memory (p <...