A5023245401- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Multiple and Secondary Primary Cancers
- Renal and related cancers
- Nutrition, Genetics, and Disease
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- Melanoma and MAPK Pathways
Bashkir State Medical University
2017-2025
Republican Oncological Clinical Dispensary
2019-2024
Ministry of Health
2020-2024
Autonomous Healthcare
2023
Ministry of Health
2020-2021
The article presents a clinical case of congenital pigmented giant nevus treatment located on the skin right gluteal region in 26-year-old patient. Considering size and localization nevus, we used method expander dermotension, which allowed us to perform surgery 2 stages achieve satisfying cosmetic results.
The article presents a draft of clinical recommendations for the diagnosis and treatment differentiated thyroid cancer in adult patients, which provides modern examination algorithm, discusses basic principles laboratory, instrumental diagnostics approaches.
The article presents a draft of clinical recommendations for the diagnosis and treatment medullary thyroid cancer in adult patients, which provides modern examination algorithm, discusses basic principles laboratory, instrumental diagnostics approaches.
Данный обзор посвящен механизмам работы противоопухолевого иммунитета и особенностям его формирования. Ингибиторы контрольных точек иммунного ответа изменили парадигму лечения больных со злокачественными новообразованиями (ЗНО). Иммунотерапия при многих ЗНО показала превосходящую стандартные химиотерапевтические опции эффективность. В данной работе представлен литературных данных о механизмах формирования специфического резистентности к препаратам контроля иммунных точек. Для определения...
Активирующие мутации в гене PIK3CA при гормонозависимом HER2-негативном (HR+ HER2–) метастатическом раке молочной железы (РМЖ) ассоциированы с повышенной частотой метастазирования головной мозг (ГМ). Данные об эффективности таргетных препаратов поражении головного мозга, особенно активных симптомных метастазах, ограничены, поскольку клинические исследования включают, как правило, пациентов со стабильными метастазами после проведённой ранее лучевой терапии на метастазы ГМ.
 В данной...
In breast cancer, genetic profile and expression of immunohistochemical markers determine prognosis treatment scheme. Triple-negative cancer is characterized by absence hormone receptor negative HER2 status, as well high proliferative index. These features the tumor tissue limit doctors» selection antitumor drugs. Development triple-negative variant associated with a mutation in BRCA1/2 gene. Consequently, determination mutations prognostic biomarker, presence immune checkpoint proteins,...
The excisional rings of the T cell receptor rearrangement (TREC) and κ-deletion element (KREC) are extrachromosomal DNA structures formed during V(D)J-recombination. A decrease in number TREC KREC below age-related values may be a manifestation immunodeficiency conditions, which can caused by oncological hematological diseases. Objective: To study change amount breast cancer. Methods. For study, blood was taken from patients with malignant neoplasms main group healthy women various ages. Of...
Background. The implementation of tyrosine kinase inhibitors into clinical practice improved treatment outcomes in patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC). Lenvatinib is recommended as a first-line drug for these patients. study objective to analyze experience lenvatinib RR-DTC the Russian Federation. Materials and methods. data from 18 sites Russia was analyzed period December 2015 September 2019. Seventyseven histologically verified DTC, proven...
Cervical cancer (CC) remains one of the common tumour diseases women. It accounts for 9.8% all neoplasia in The Food and Drug Administration approved pembrolizumab with PD-1 inhibitor antibodies treatment RSM following KEYNOTE-158 clinical trial. PD-L1/PD-1 inhibitors have shown promising results against objective response rate female patients CC. A case a patient metastatic CC progression after radiotherapy pelvic organ evisceration is described. underwent IHC examination material was found...
Introduction. Surgical intervention remains the main method for treatment of oral mucosa cancer. The generally accepted standard resection boundary that provides optimal local control is 5 mm. Adequate boundaries indentation and choice reconstruction are important issues facing specialists in head neck tumors. Aim. To evaluate parameters edge surgical malignant neoplasms depending on eliminating post-resection defect its effect frequency relapse. Materials methods. A retrospective analysis...
Introduction. The present article discusses renal cancer, one of the common malignant diseases. Historical and modern therapies are considered, including tyrosine kinase inhibitors immune checkpoint inhibitors. results clinical studies evaluating efficacy combined drug therapy discussed, combination with angiogenesis targeted therapy. Materials methods. A case is presented a patient metastatic clear cell carcinoma multiple lung metastases. diagnosis was established using computed tomography...
Background. The combination of alpelisib with fulvestrant is the optimal targeted endocrine therapy for patients hormone-positive (HR+) HER2-negative (HER2-) metastatic breast cancer (mBC) mutations in PIK3CA gene. This regimen has been shown to be highly effective large phase II and III studies. However, randomized clinical trials cannot fully cover all possible populations pre-treated patients. Therefore, real-world study efficacy safety + warranted.
 Aim. A retrospective analysis...
e13058 Background: The combination of alpelisib and fulvestrant is an optimal therapy option for patients with hormone receptor-positive (HR+), HER2-negative (HER2–) metastatic breast cancer PIK3CA gene mutations. aim this work to retrospectively analyze the efficacy safety in real-world clinical practice pre-treated luminal HER2– negative cancer. Methods: study included analysis 33 widespread HER2- detected mutation. median age was 57 ± 13 months (95% CI 52-62). In 12 (36.4%) patients,...
Sentinel lymph node biopsy (SLNB) in cutaneous melanoma is a staging step cases of unaffected regional nodes. This method included routine practice many medical facilities the Russian Federation. Aim. To analyze results SLNB performed using gamma scintigraphy technique with 99mTc-containing technefit radiopharmaceutical agent. Materials and methods . The prospective study 97 patients (39.2 % (38/97) men 60.8 (59/97) women) primary who received surgical treatment at Republican Clinical...
Background. In oncology, of particular interest is the study T-cell receptor excision circles (TREC) and κ-deletion B-cell (KREC), which are extrachromosomal DNA structures. many malignancies, effectiveness immune checkpoint inhibitors depends on mutational load tumor, correlates with formation specific antitumor immunity. Quantitative indicators recombination reflect occurrence a different repertoire receptors, an integral component in Understanding change quantitative values TREC KREC...
e21547 Background: The special interest in oncology is the research of immune status patients. Quantification T-cell receptor excision rings (TREC) and B-cell κ deletion elements (KREC) allows to evaluate a humoral cellular immunity. In melanoma, effectiveness use drugs control points depends on formation specific antitumor Quantitative indicators recombination reflect different repertoire receptors, which are an integral component understanding changes TREC levels patients with melanoma...
The MET gene encodes cell surface receptors that have tyrosine kinase activity and mediates embryonic development, organogenesis, wound healing. Overexpression of is observed in some human cancers, including non-small lung cancer. Capmatinib a selective type Ib inhibitor MET. A total 151 patients with exon 14 skipping mutations were enrolled the GEOMETRY-mono 1 study. ORR achieved was 51% receiving second-line chemotherapy, median PFS 6.9 months. We present clinical case NSCLC treatment...
Introduction. A breakthrough in the treatment of metastatic hormone-dependent (HR+) breast cancer was combination endocrine therapy with CDK4/6 inhibitors, which significantly prolonged tumor response time to and median survival before progression. The effectiveness real-life practice is particular interest due wider population patients different somatic status comorbidity, often not included randomized trials. Aim. Analyze palbociclib using for treating HR+/HER2– advanced (mBC) at...