A5084467667- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Airway Management and Intubation Techniques
- Respiratory and Cough-Related Research
- Breastfeeding Practices and Influences
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Neurogenetic and Muscular Disorders Research
- Tracheal and airway disorders
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Connective tissue disorders research
- RNA modifications and cancer
- COVID-19 Impact on Reproduction
- Birth, Development, and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Anomalies and Fetal Surgery
- Foreign Body Medical Cases
- Head and Neck Surgical Oncology
- Eosinophilic Disorders and Syndromes
- Child and Adolescent Health
Tel Aviv University
2016-2025
Wolfson Medical Center
2020-2025
Edmond and Lily Safra Children's Hospital
2023
Sheba Medical Center
2023
Tel Aviv Sourasky Medical Center
2013-2021
Cincinnati Children's Hospital Medical Center
2017-2020
Pulmonary Associates
2018
SleepMed
2016
Abstract Background The emergence of new treatments for spinal muscular atrophy (SMA) is revolutionary, especially SMA type 1 (SMA1). Data on respiratory outcomes remain sparse and rely mostly randomized clinical trials. We report our experience Nusinersen‐treated SMA1 patients in real‐world settings. Methods from treated with Nusinersen were prospectively collected between 1/2017 1/2020. Respiratory variables included the use assisted ventilation, mechanical insufflation‐exsufflation (MIE),...
Adenotonsillectomy is the recommended treatment for children with obstructive sleep apnea (OSA). Since adenoidectomy alone may be associated significantly lower morbidity, mortality, and cost, we aimed to investigate whether a reasonable appropriate OSA.
The contribution of ventilatory control to the pathogenesis obstructive sleep apnea (OSA) in preterm-born children is unknown.
To compare the Respiratory Syncytial Virus (RSV) hospitalization burden among 29-34 weeks gestational age (wGA) preterm infants between seasons with and without routine palivizumab prophylaxis, by utilizing 2021 off-season RSV surge. This multi-center retrospective study was conducted in 11 medical centers across Israel. We included > 1 year-old, wGA data, hospitalized infection from November 2017-August 2021. National compliance data were collected separately. compared two periods:...
<b>Objective</b> Oral probiotic supplementation reduces the risk of necrotizing enterocolitis (NEC) in preterm infants. Concerns about safety and purity preparations have limited their use The authors administered bacteria to mothers infants, thereby avoiding risks direct exposure infants bacteria. <b>Design</b> This prospective, randomized, double blind, placebo-controlled trial at Tel Aviv Medical Center (June 2007–November 2009) examined effects maternal oral on incidence NEC, death,...
Air pollution triggers and exacerbates airway inflammation. Particulate material (PM) in ambient is characterized as being coarse (PM 10, aerodynamic diameter range 2.5-10 µm), fine 2.5, 2.5-0.1 µm) ultrafine (UFP, nano-sized, <0.1 µm). It known that smaller inhaled PM produced more inflammation than larger ones. Most data on human exposure to are based environmental monitoring. We evaluated the effect of individual UFP functional respiratory parameters 52 children aged 6-18 years referred...
The nature of sleep disorders in children with Ehlers-Danlos syndrome (EDS) is unknown. We aimed to describe the type, management, and short-term outcome EDS referred clinics.This a retrospective review medical records polysomnography tests younger than 18 years who were clinic. Demographic information history collected, reviewed. Questionnaires completed during previous clinic visits, including Pediatrics Sleep Questionnaire (PSQ), Epworth Sleepiness Scale (ESS), Pediatric Quality Life...
Abstract Study Objectives To examine the role of ventilatory control in asthmatic children with obstructive sleep apnea (OSA) and relationships between measures control, OSA severity, pulmonary function. Methods Five- to 18-year-old persistent asthma nightly snoring were enrolled study. Children had physical examination, function test, polysomnography. Loop controller gains derived from 5 min segments which included a sigh during nonrapid eye movement by applying mathematical model that...
Laryngomalacia is the most prevalent cause of congenital stridor. Flexible laryngobronchoscopy (FLB) gold standard for diagnosis. However, FLB requires venous access, deep sedation or general anesthesia, and associated with patient's parental discomfort a considerable cost. Laryngeal ultrasound (LUS) has been shown to provide good evaluation normal anatomy dynamic motion laryngeal structures. We investigated yield LUS in diagnosis laryngomalacia infants stridor compared FLB.A prospective...
Abstract Study Objectives Obstructive sleep apnea (OSA) adversely affects normal blood pressure (BP) and may disrupt circadian BP patterns. We sought to examine 24-hour rhythms in children with OSA healthy controls. Methods Children 5–14 years controls underwent monitoring actigraphy quantify sleep. Shape invariant statistical models compared patterns (e.g. times of peaks, time arrived at peak velocity [TAPV]) the control groups. Results The analytic sample included 219 (mild OSA: n = 52;...
The contribution of ventilatory control to the pathogenesis obstructive sleep apnea (OSA) in children and effect adenotonsillectomy are unknown. We aimed examine difference between with OSA those without OSA. also examined on parameters control.Healthy matched controls were recruited. Polysomnography was performed before group 6 months postoperatively. Controls underwent same assessment at two time points. Loop gain (LG), controller (CG), plant (PG), which reflect stability control,...
To test the null hypothesis that mothers of asymmetric small for gestational age (SGA) infants produce milk with fatty acids composition similar to lactating appropriate-for-gestational-age (AGA) infants.We obtained human (HM) from 2 groups volunteers gave birth SGA (study group) or AGA (control group). Each mother was asked contribute by manual expression at least one 3 samples: first 72 hours after labor (colostrum), day 2-7 postpartum (transitional milk) and 14 days post partum (mature...
To evaluate the incidence of wheezing and overall respiratory morbidity in healthy infants born during first peak coronavirus disease-2019 (COVID-19) pandemic, compared with preceding year.This was a single-center retrospective birth cohort study to compare children between February March 2020 (COVID-19 group) control group 2019 (pre-COVID-19 group). At 1 year age, we collected data using parental telephone questionnaires.wheezing and/or bronchodilator use.recurrent wheezing, emergency-room...
Candidemia is a serious complication in pediatric patients with congenital heart defects (CHD) after cardiac surgery. Information about the epidemiology, clinical characteristics and risk factors for candidemia this vulnerable population remains limited.This retrospective case-control study was conducted 2 intensive care units between 2004 2019. All <18 years old who developed following surgery were included. Each case matched control based on age date of Multivariable logistic regression...
<b>Background:</b> The emergence of new treatments for spinal muscular atrophy (SMA) is revolutionary, especially SMA type 1 (SMA1) patients. Data on respiratory outcomes remain sparse and rely mostly randomized clinical trials. We present here our experience in real world settings. <b>Methods:</b> from patients with SMA1 treated Nusinersen were prospectively collected before treatment initiation after 2 years. Respiratory variables included use assisted ventilation mechanical...
Abstract Although Mycobacterium fortuitum (MF) is a non‐tuberculous mycobacterium that rarely causes disease, there are reported cases of pneumonia, lung abscess, and empyema in subjects with predisposing disease. We report neonate, without disease or risk factors, who manifested pneumonia abscess. The patient was initially treated amoxicillin‐clavulanic acid gentamycin, subsequently piperazilin, tazobactam, vancomycin when no improvement. Pleural nodules were detected on computed...
Objective: Increased eosinophil level in bronchoalveolar lavage fluid (BALF) characterizes asthma school-age children and adults has been suggested as a marker for disease severity response to treatment. We aimed investigate the occurrence yield of BALF cell count preschool with recurrent wheezing its possible relation future diagnosis asthma. Methods: was retrospectively studied young wheezy at age 6 years evaluated. from aged 1–48 months (mean = 20.4) analyzed children. Children anatomical...
Abstract Background Fractional exhaled nitric oxide (FeNO) is a biomarker for eosinophilic inflammation used diagnosis and monitoring of asthma. High FeNO indicates significant airway eosinophilia steroid‐responsive inflammation. Some children with asthma have extremely high levels, but whether these levels represent different phenotype compared those mildly elevated unclear. The objective this study to investigate the extent correlates clinical phenotype, control, comorbidity, pulmonary...
Bronchial challenge test (BCT) measures current airways-hyperreactivity, however, its predictive role in pre-school children (<6 years) for the diagnosis of asthma at school age is still debatable. We aimed to find whether preschool with a positive adenosine or methacholine BCT are more prone age.We included aged 6-13 years respiratory symptoms that were previously referred our pulmonary function laboratory (methacholine adenosine, depending on question asked) 10 months 6 (baseline). was...
No consensus guidelines exist for the respiratory treatment of asthmatic children referred elective surgery. The aim this study was to evaluate attitude pediatric pulmonologists regarding pre-operative management these children.A survey conducted. All 48 certified in Israel completed a questionnaire that comprised 20 questions their approach including six case scenarios with variety clinical situations and treatments asthma.Response rate 100%. believed should be considered all children....