A5058438100- Medieval Iberian Studies
- Medieval and Early Modern Iberia
- Retinal Diseases and Treatments
- Medieval Architecture and Archaeology
- Retinal Development and Disorders
- Archaeological and Historical Studies
- Historical Studies of Medieval Iberia
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Photoreceptor and optogenetics research
- Classical Studies and Legal History
- Early Modern Spanish Literature
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Angiogenesis and VEGF in Cancer
- Retinal and Macular Surgery
- Libraries, Manuscripts, and Books
- Medieval Literature and History
- Medieval and Early Modern Justice
- Spanish Literature and Culture Studies
- melanin and skin pigmentation
- Medieval European Literature and History
Houston Eye Associates
2022-2024
Centre d'études supérieures de civilisation médiévale
2007-2021
Université de Poitiers
2012-2020
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2020
The University of Texas Health Science Center at Houston
1996-2019
Centre d'Etudes Supérieures de la Renaissance
2010-2019
University of the Incarnate Word
2019
The University of Texas at Austin
1983-2015
Robert Cizik Eye Clinic
1982-2005
University of Houston
2005
This study was designed to investigate the in vitro degradation of thin poly(DL-lactic-co-glycolic acid) (PLGA) films for applications retinal pigment epithelium transplantation and guided tissue regeneration. PLGA copolymer ratios 75:25 50:50 were manufactured with thickness levels 10 μm (thin) 100 (thick). Degradation occurred during sample processing, a higher surface area volume ratio degraded faster. Sample weight loss, molecular dimensional, morphological changes analyzed over 10-week...
To survey families with clinical evidence of autosomal dominant retinitis pigmentosa (adRP) for mutations in genes known to cause adRP.Two hundred adRP families, drawn from a cohort more than 400 potential were selected by analysis pedigrees. Minimum criteria inclusion the included either at least three generations affected individuals or two male-to-male transmission. Probands each family screened 13 adRP: CA4, CRX, FSCN2, IMPDH1, NRL, PRPF3 (RP18), PRPF8 (RP13), PRPF31 (RP11), RDS, RHO,...
<h3>Objective</h3> To compare 2 laser photocoagulation techniques for treatment of diabetic macular edema: the modified Early Treatment Diabetic Retinopathy Study (ETDRS) direct/grid technique and a potentially milder (but more extensive) mild grid (MMG) in which microaneurysms are not treated directly small burns placed throughout macula, whether or edema is present. <h3>Methods</h3> Two hundred sixty-three subjects (mean age, 59 years) with previously untreated were randomly assigned to...
Journal Article DIABETES AMONG MEXICAN AMERICANS IN STARR COUNTY, TEXAS Get access CRAIG L. HANIS, HANIS 1Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University Texas Health Science Center at Houston, TX Reprint requests to Dr. Hanis, P.O. Box 20334, 77025. Search other works by this author on: Oxford Academic PubMed Google Scholar ROBERT E. FERRELL, FERRELL SARA A. BARTON, BARTON LYDIA AGUILAR, AGUILAR ANA GARZAIBARRA, GARZAIBARRA BRIAN R....
To identify specific mutations causing North Carolina macular dystrophy (NCMD).Whole-genome sequencing coupled with reverse transcription polymerase chain reaction (RT-PCR) analysis of gene expression in human retinal cells.A total 141 members 12 families NCMD and 261 unrelated control individuals.Genome was performed on 8 affected individuals from 3 chromosome 6-linked (MCDR1) 2 5-linked (MCDR3). Variants observed the MCDR1 locus frequencies <1% published databases were confirmed using...
Alterations in the normal structure or functions of retinal pigment epithelium (RPE) can result a number ocular diseases. Implantation RPE cells cultured on thin, biodegradable polymer films may provide means transplanting an organized sheet with distinct apical/basal characteristics for restoration function. We have investigated interactions human different to assess their suitability as substrates culture. Four polymers were used: low molecular weight (MW) 50:50 poly(DL-lactic-co-glycolic...
We studied the biodegradation of and tissue reaction to microspheres 50:50 poly(D,L-lactic-co-glycolic)acid (PLGA) (viscosity-average MW: 3000 d), injected intravitreous in rabbits. These are under investigation as injectable devices for sustained drug delivery. The rate degradation PLGA has not been well documented literature. Twenty two pigmented rabbits underwent gas vitrectomy one eye: 19 eyes received 2.5 mg 1 ml balanced salt solution (BSS) 3 control BSS only. Slit lamp exam indirect...
To identify the cause of retinitis pigmentosa (RP) in UTAD003, a large, six-generation Louisiana family with autosomal dominant (adRP).A series strategies, including candidate gene screening, linkage exclusion, genome-wide mapping, and whole-exome next-generation sequencing, was used to mutation novel disease on chromosome 10q22.1. Probands from an additional 404 retinal degeneration families were subsequently screened for mutations this gene.Exome sequencing UTAD003 led identification...
Short-term (15 minutes) in vitro exposure to kainic acid (KA), a rigid structural analog of L-glutamic (Glu), caused two morphologically distinct neuronal lesions retinas several species. In rabbit retina, one type lesion was characterized by rapid swelling after low concentrations KA (10(-4)M). This observed elements both plexiform layers and, more specifically, cell bodies and neurites horizontal cells that contact cones. A few from the amacrine layer showed some limited swelling. The...
To determine the rate and risk factors of mortality in a cohort Mexican Americans with NIDDM.A 353 NIDDM were identified between 1981 1986. All individuals underwent extensive evaluations that included physical, historical, ophthalmological, laboratory assessments. This was followed prospectively for mean 8 yr. Follow-up surveillance, death certificate extraction, combination annual intermediate examinations.The experienced 67 events. One-third all deaths premature < 65 yr age) most often...
Thin films of 50:50 and 75:25 poly(DL-lactic-co-glycolic acid) (PLGA) were manufactured with a controlled thickness less than 10 microm. The effect PLGA copolymer ratio on in vitro cell attachment, proliferation, morphology, tight junction formation was evaluated using human D407 retinal pigment epithelium (RPE) line. Almost complete attachment achieved both after 8 h seeding, which comparable to that tissue culture polystyrene (TCPS) controls. initial seeding density affected the optimal...
Abstract Obesity is a complex, multifactorial chronic disease that poses significant health risks. Recent advancements in artificial intelligence (AI) offer the potential for more personalized and effective dietary supplement (DS) regimens to promote weight loss. This study aimed evaluate efficacy of AI-guided DS prescriptions compared standard physician-guided obese patients. randomized, parallel-group pilot enrolled 60 individuals aged 40 years with body mass index (BMI) 25 or greater....
Abstract Emerging evidence suggests that personalized dietary supplement regimens can significantly influence lipid metabolism and cardiovascular risk. The efficacy of AI-guided prescriptions, compared to standard physician-guided remains underexplored. In a randomized, parallel-group pilot study, 70 patients aged 40-75 years with LDL-C levels between 70-190 mg/dL were enrolled. Participants randomized receive either prescriptions or for 90 days. primary endpoint was the percent change in...
Abstract This study evaluated the efficacy of an AI-guided dietary supplement regimen compared to a standard physician-guided in managing Type 2 diabetes (T2D). A total 160 patients were randomly assigned either group (n=80) or and followed over 90 days. The received 5.3 ± 1.2 supplements per patient, while 2.7 0.6 patient. AI system personalized types dosages based on individual genetic metabolic profiles. showed significant reduction HbA1c levels from 7.5 0.8% 7.1 0.7%, 7.6 0.9% 7.4 (mean...