Implantable biosensors have evolved to the cutting-edge technology of personalized health care and provide promise for future directions in precision medicine. This is reason why these devices stand revolutionize our approach disease management offer insights into bodily functions ways that never been possible before. review article tries delve important developments, new materials, multifarious applications biosensors, along with a frank discussion on challenges will face their clinical...

Aptamers are nucleic acid oligomers synthesized from groups of arbitrary oligonucleotides to bind a wide range bio-targets with high specificity and affinity that comparable antibodies. In the last decade, label-free electrochemical cancer aptasensors based on biomarker whole-cell detection have been demonstrated be highly sensitive, faster, more stable than typical clinical techniques. Compared optical aptasensors, promising lab-on-chip candidates for portable applications since their...

We report on a highly sensitive, selective, and flexible enzymatic sensor based Zinc oxide nanoflakes (ZnO NFs) for noninvasive L-lactate sensing in sweat. A single step sonochemical process was used to synthesize ZnO NFs gold-coated polyethylene terephthalate (PET) substrates. The lactate oxidase enzyme (LOx) immobilized the as-synthesized ZnO-NFs-based electrode provided high level of selectivity sensing. tested range 10 pM-20 mM, which covers entire physiologicalrange demonstrated...

In this study, a highly sensitive electrochemical capacitive lactic acid enzymatic sensor based on carbon-microelectromechanical system (C-MEMS) is developed. The sensing platform of the biosensor, which photoresist-derived carbon (PDC) microelectrode, was synthesized by pyrolysis photo-patterned photoresist polymer in oxygen-free and high-temperature conditions. surfaces microelectrodes were functionalized oxygen-plasma pretreatment technique to form -COOH functional groups. lactate oxidase...

The developed cancer biomarker aptasensor based on bipolar exfoliated graphene electrodes has high potential for scale up and mass production due to the low cost efficiency of process affinity DNA aptamers.

We report on highly sensitive and flexible biosensors for noninvasive lactate monitoring in human sweat based zinc oxide (ZnO) nanostructures that do not require linker layer surface functionalization. Towards fabrication of the two-dimensional (2D) ZnO nanoflakes (NFs) were synthesized polyethylene terephthalate (PET) substrates by using single step sonochemical method. The cyclic voltammetry (CV) measurements concentration range 10 pM - 20 mM yielded sensitivity 11.76 μA/decade/cm <sup...

Continuous monitoring of alcohol detection is imperative for the prevention accidents, point care monitoring, and personal safety. The cutting-edge technologies are mostly focused to detect from breath (e.g. breathalyzer), which not compatible real-time monitoring. relationship between blood concentrations improvement techniques biomarkers sweat render an opportunity Due its prolonged existence in sweat, Ethylglucuronide (EtG) considered as one most promising detection. We report on...

A miniaturized potentiostat integrated with a three-electrode system to monitor different analytes is presented. The circuit has been designed have the feature of four-channel multiplexing operate electrochemical cells simultaneously. It Bluetooth-connected user-controlled mobile app through which wirelessly controlled and data acquired. personalized from analysis are displayed analyzed in app. comprised four units: digital analog converter (DAC), unit, control current voltage (CVC). run by...

We report a wearable, continuous and noninvasive monitoring of sweat pH platform. Recently there has been surge in research to develop highly stable sensitive sensors for several biochemical biological processes. is all dynamic parameter comprehensive range applications as provides information about the body’s metabolic activity, well physiological responses. With expansion nano technology, based on nanomaterials have investigated by researchers. Among numerous metal oxide-based...

We report on label free highly sensitive electrochemical immunosensor for monitoring alcohol consumption through the detection and quantification of ethyl glucuronide (EtG) -a metabolite ethanol-based two-dimensional (2D) zinc oxide (ZnO) nanoflakes (NFs), which were synthesized flexible Au-coated polyethylene terephthalate (PET) substrate using simple one step sonochemical approach. Highly EtG cyclic voltammetry (CV) is achieved by immobilizing antibody as-synthesized sensing electrodes ZnO...

Cancer biomarkers are substances found in the human fluid, tissue, and bone marrow that can indicate presence of cancer diseases body. In past decades, various have been discovered for early detection cancers risk assessment reoccurring cancers. Among biomarkers, platelet-derived growth factor-BB (PDGF-BB) is an essential biomarker diseases. This plays a significant role development multiple solid malignant tumors (e.g., breast, brain, pancreatic, prostate, ovarian) lymphatic metastasis. A...

Early detection of cancer can noticeably increase the survival chance many patients. Quantifying biomarkers detectable from blood is an efficient way for early diseases. Among various discovered biomarkers, platelet-derived growth factor-BB (PDGF-BB) essential biomarker and monitoring This plays a vital role in developing lymphatic metastasis solid malignant tumors such as brain, lung, breast, liver; which enlightens importance point-of-care (POC) biosensors PDGF-BB. In recent years,...

Commercialization of biosensors has been limited due to their accuracy and reliability. Creating intelligent automatically predict concentrations analytes based on some decision system would overcome this challenge. Many advanced machine learning algorithms for data processing are emerging becoming a hot topic research scientists worldwide, but application in biosensors, particularly wearable systems is still limited. Wearable lactate sensors an field continuous personal health monitoring....