A5061491137- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Advanced Radiotherapy Techniques
- Ovarian cancer diagnosis and treatment
- Management of metastatic bone disease
- MRI in cancer diagnosis
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Effects of Radiation Exposure
- AI in cancer detection
- Gastric Cancer Management and Outcomes
- PARP inhibition in cancer therapy
- Genetic factors in colorectal cancer
- Advances in Oncology and Radiotherapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Uterine Myomas and Treatments
- Nonmelanoma Skin Cancer Studies
- Colorectal Cancer Treatments and Studies
- Medical Imaging Techniques and Applications
- Endometriosis Research and Treatment
- Ocular Oncology and Treatments
- Brain Metastases and Treatment
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Beatson West of Scotland Cancer Centre
2019
Università Cattolica del Sacro Cuore
2015-2018
Advanced Radiation Therapy (United States)
2018
Institut Curie
2009-2016
Chalmers University of Technology
2015
Hospital Universitario Virgen del Rocío
2015
Specific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human DNA is thus tumour marker that can be detected in the blood patients for clinical monitoring. However, data concerning circulating cervical cancer has provided little value, due to insufficient sensitivity assays used detection small sized tumours. Here we took advantage sensitive droplet digital PCR method identify papillomavirus-associated A series...
Introduction In most cases of cervical cancers, HPV DNA is integrated into the genome carcinoma cells. This mutational insertion constitutes a highly specific molecular marker tumor for every patient. Circulating (ctDNA) an emerging dynamics which detection requires motif. To determine whether sequence cell-viral junction could be used in clinical practice as ctDNA, we analyzed series cancer patient serums. Methods and Findings Serum specimens 16 patients diagnosed with HPV16/18-associated...
Abstract Cancer treatment is facing major evolution since the advent of targeted therapies. Building genetic profiles could predict sensitivity or resistance to these therapies and highlight disease‐specific abnormalities, supporting personalized patient care. In context biomedical research clinical diagnosis, our laboratory has developed an oncogenic panel comprised 226 genes a dedicated bioinformatic pipeline explore somatic mutations in cervical carcinomas, using high‐throughput...
Magnetic resonance-guided radiotherapy (MRgRT) represents an innovative approach for personalized treatments and its applications are being explored in various anatomical sites to fully understand potential advantages. This study describes the first clinical experience of MRgRT application patients with locally advanced cervical cancer (LACC) undergoing neoadjuvant chemoradiotherapy. The feasibility technique is evaluated toxicity profile outcomes reported.Patients LACC (International...
Objective This retrospective, multicenter study analyzes the efficacy and safety of stereotactic body radiotherapy in a large cohort patients with oligometastatic/persistent/recurrent cervical cancer. Methods A standardized data collection from several centers that treated by between March 2006 February 2021 was set up. Clinical parameters were collected. response rate defined as composite complete partial response, while clinical benefit included objective plus stable disease. Radiation...
Background: Recent studies have highlighted the potentialities of a radiobiological parameter, early regression index (ERITCP), in treatment response prediction for rectal cancer patients treated with chemoradiotherapy followed by surgery. The aim this study is to evaluate performance parameter predicting pathological complete (pCR) context low field MR guided radiotherapy (MRgRT) cervical (CC). Methods: A total 16 affected CC were enrolled. All underwent MRgRT treatment, prescription 50.6...
To compare the survival and toxicity outcomes in patients with endometrial cancer treated either high-dose-rate (HDR) or low-dose-rate (LDR) vaginal brachytherapy (VBT) following external beam radiotherapy (EBRT).From January 2000 to December 2014, after radical hysterectomy with/without pelvic and/or para-aortic lymphadenectomy were adjuvant EBRT (45 Gy, 1.8 Gy/day whole pelvis) subsequent VBT boost (HDR dose of 7 Gy one fraction LDR 25 Gy). The was prescribed at 0.5 cm from surface...
Background: HAPPY (Humanity Assurance Protocol in Interventional Radiotherapy) reports the necessity for gynecological cancer patients to undergo interventional radiotherapy (IRT, also called brachytherapy). The present paper has evaluated how some precautions may improve psychological well-being of during IRT. Methods: Patients with undergoing IRT-HDR were analyzed. answered three questionnaires before IRT procedure (T0) and at end (T1): Distress Thermometer (DT), Numerical Rating Scale...