A5059161145- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
- Diabetes and associated disorders
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Pharmaceutical and Antibiotic Environmental Impacts
- Alzheimer's disease research and treatments
- Biochemical effects in animals
- Antibiotic Resistance in Bacteria
- Nanoparticle-Based Drug Delivery
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
- Mangiferin and Mango Extracts
- Plant biochemistry and biosynthesis
- Phytochemistry and biological activities of Ficus species
- Phytochemistry and Biological Activities
- Cholinesterase and Neurodegenerative Diseases
- Antioxidant Activity and Oxidative Stress
- Algal biology and biofuel production
- Pharmacological Effects of Natural Compounds
- Enzyme Production and Characterization
- Diabetes Management and Research
University of Ha'il
2019-2025
Chandigarh University
2024
Integral University
2014-2023
King Hussein Cancer Center
2019-2022
The University of Agriculture, Peshawar
2021
King Saud University
2017
King George's Medical University
2016
Aligarh Muslim University
2011-2015
Federal University Dutse
2015
Universidad Complutense de Madrid
2015
Non-enzymatic glycation is the addition of free carbonyl group reducing sugar to amino groups proteins, resulting in formation a Schiff base and an Amadori product. Dihydroxyacetone (DHA) one species which reacts rapidly with proteins form advanced end products (AGEs). The highly reactive dihydroxyacetone phosphate derivative (DHA), product glycolysis, having potential glycating effects AGEs. AGEs results generation radicals play important role pathophysiology aging diabetic complications....
The present study on Phyllanthus virgatus, known traditionally for its remedial potential, the first time provides descriptions of antioxidant and inhibition α -amylase enzyme activity by in vitro analyses, followed a confirmatory silico to create stronger biochemical rationale. Our results illustrated that P. virgatus methanol extract exhibited strong oxidative DNA damage protective than other extracts, which was well correlated with total phenolic content. In addition, strongly inhibited...
Advanced glycation end products (AGEs) culminate from the non-enzymatic reaction between a free carbonyl group of reducing sugar and amino proteins. 3-deoxyglucosone (3-DG) is one dicarbonyl species that rapidly forms several protein-AGE complexes are believed to be involved in pathogenesis diseases, particularly diabetic complications. In this study, generation AGEs (Nε-carboxymethyl lysine pentosidine) by 3-DG H1 histone protein was characterized evaluating extent side chain modification...
This study initially aimed to depict the molecular rationale evolving role of lycopene in inhibiting enzymatic activity β-hydroxy-β-methylglutaryl-CoA (HMG-CoA) reductase via vitro and silico analysis. Our results illustrated that exhibited strong HMG-CoA inhibitory (IC50 value 36 ng/ml) quite better than pravastatin = 42 DPPH free radical scavenging 4.57 ± 0.23 μg/ml) as compared ascorbic acid 9.82 0.42 μg/ml). Moreover, Ki (36 depicted Dixon plot was well concurred with an IC50 1.8 ng/ml....
Abstract There are accumulating evidences suggesting that interaction between advanced glycation end products (AGEs) and their receptors (RAGEs) induces oxidative stress subsequently encourages inflammatory reactions, thereby resulting in progressive alteration renal architecture function. Interventions reduce the tissue burden of AGEs have yielded significant positive results inhibiting progression diabetic complications such as nephropathy. Lycopene, a carotenoid, plays an important role...
Advanced glycation end-products (AGEs) are heterogeneous group of compounds, known to be implicated in diabetic complications. One the consequences Maillard reaction is attributed production reactive intermediate products such as α-oxoaldehydes. 3-deoxyglucosone (3-DG), an α-oxoaldehyde has been found involved accelerating vascular damage during diabetes. In present study, calf thymus histone H3 was treated with investigate generation AGEs (Nε-carboxymethyllysine, pentosidine), by examining...
Advanced glycation end-products (AGEs) are known to be mutagenic, diabetogenic and vascular disease risk factors. Methylglyoxal (MG) is a dicarbonyl species that reacts with biological macromolecule (proteins, DNA lipids) give AGEs. Nonenzymatic of MG lysine (Lys) in the presence copper (Cu(2+)) reported generate reactive oxygen (ROS) capable causing damage. We show modification MG-Lys-Cu(2+) system results generation strand breaks, base modification, hyperchromicity increased fluorescence...
Abstract Advanced glycation end‐products comprise a complex and heterogeneous group of compounds that have been implicated in diabetes‐related complications. The importance the Maillard reaction is depicted by formation reactive intermediate products known as α‐oxoaldehydes, such 3‐deoxyglucosone (3‐DG). This product has found to be involved accelerated vascular damage diabetes. In present study, calf thymus histone H2A was reacted with 3‐DG, generation advanced end investigated determining...
The current perspective for the search of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor has been shifted towards a natural agent also having antioxidant property. Thus, this study was intended to isolate and identify bioactive compounds from methanolic extract Ficus virens bark (FVBM) evaluate their antioxidant, HMG-CoA inhibitory hypolipidemic activity. Bioactivity guided fractionation isolation compound FVBM done characterize potent (HMGR) with activity by using...