A5083152224- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Antibiotic Resistance in Bacteria
- Complementary and Alternative Medicine Studies
- Adenosine and Purinergic Signaling
- Click Chemistry and Applications
- Synthesis and Characterization of Pyrroles
- Bacteriophages and microbial interactions
- Echinoderm biology and ecology
- Cyclopropane Reaction Mechanisms
- Antibiotic Use and Resistance
- Clostridium difficile and Clostridium perfringens research
- Chemical Synthesis and Analysis
- Escherichia coli research studies
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Microbial Metabolites in Food Biotechnology
- Antimicrobial Resistance in Staphylococcus
- Seaweed-derived Bioactive Compounds
- Synthesis of heterocyclic compounds
Université de Nîmes
2019-2024
Université de Montpellier
2023
Institut des Biomolécules Max Mousseron
2023
Abstract Various series of 4,6‐biaryl‐2‐thiopyridine derivatives were synthesized and evaluated as potential ecto‐5′‐nucleotidase (CD73) inhibitors. Two synthetic routes explored the coupling 4,6‐disubstituted 3‐cyano‐2‐chloro‐pyridines with selected thiols allowed us to explore structural diversity. Somehow divergent results obtained in biological assays on CD73 inhibition using either purified recombinant protein or cell‐based assays, highlighting difficulty target protein‐protein...
Infections caused by drug-resistant bacteria are a serious threat to human and global public health. Moreover, in recent years, very few antibiotics have been discovered developed pharmaceutical companies. Therefore, there is an urgent need discover develop new antibacterial agents combat multidrug-resistant bacteria. In this study, two novel series of juglone/naphthazarin derivatives (43 compounds) were synthesized evaluated for their properties against various clinical reference...
Sargassum is a genus of brown algae that causes major impact to marine ecosystems. Although accumulation this invasive seaweed considered an environmental problem, can also be resource valuable molecules such as alginates. Alginates are polysaccharides extracted from the cell walls seaweeds with multiple applications in food, cosmetics, pharmaceuticals, and biotechnology. In study, we explored four different extraction protocols isolate alginates archipelago Guadeloupe. H-NMR, FTIR, SEM were...
An original and effective approach for achieving trifluoromethyl hydroxyalkylation of 5-phenylthiophen-2-amine using α-trifluoromethyl ketones is described. In the last few years, reaction Friedel-Crafts had been widely used to realize on heterocycles such as indoles or thiophenes by means Lewis acid catalyst. Additionally, amine functions are rarely free when carbonyl reagents because their tendency form imines. This first time that a site-selective electrophilic aromatic substitution C3...
In response to the antimicrobial resistance issue, World Health Organization developed and conducted a survey in 2015 dealing with habits, antibiotic use, awareness of appropriate use sensitization issue antibacterial resistance. France, we similar investigate antibiotics students’ perceptions risk. Our results indicated that are moderately taken (42% last six months), but mistakes remain practices knowledge. Many people still believe body develops 24% responded can be stopped before end...