A5064348643- Fatty Acid Research and Health
- Prostate Cancer Treatment and Research
- Bacterial Identification and Susceptibility Testing
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Antibiotic Resistance in Bacteria
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Antimicrobial Resistance in Staphylococcus
- Biochemical Analysis and Sensing Techniques
- Parkinson's Disease Mechanisms and Treatments
- Prostate Cancer Diagnosis and Treatment
- Sleep and Wakefulness Research
- Streptococcal Infections and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Diet, Metabolism, and Disease
- Antibiotics Pharmacokinetics and Efficacy
- Rabies epidemiology and control
- Iron Metabolism and Disorders
- Cholesterol and Lipid Metabolism
- Clostridium difficile and Clostridium perfringens research
- Neurological Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Microbial infections and disease research
Universidade Estadual de Maringá
2008-2021
Universidade de São Paulo
2021
Ente Ospedaliero Ospedali Galliera
2008-2020
Universidade Federal do Paraná
2013-2017
European Institute of Oncology
2009-2012
National Cancer Research Institute
2012
Cancer Institute (WIA)
2012
University of Genoa
2009
Antibiotic (Bulgaria)
2009
Portland VA Medical Center
2004-2007
Objective: Parkinson's disease (PD) is characterized by deterioration of the nigrostriatal system and associated with chronic neuroinflammation. Glial activation has been regulating survival dopaminergic neurons thought to contribute PD through release proinflammatory neurotoxic factors, such as reactive nitric oxide (NO) that triggers or exacerbates neurodegeneration in PD. Polyunsaturated fatty acids (PUFAs) exert protective effects, including antiinflammatory, antiapoptotic, antioxidant...
Abstract Depression is increasingly present in the population, and its pathophysiology treatment have been investigated with several animal models, including olfactory bulbectomy ( O bx). Fish oil FO ) supplementation during prenatal postnatal periods decreases depression‐like anxiety‐like behaviors. The study evaluated effect of on bx‐induced depressive‐like behavior cognitive impairment. Female rats received habituation, mating, gestation, lactation, their pups were subjected to bx...
Abstract An ever‐increasing body of preclinical studies has shown the multifaceted neuroprotective profile cannabidiol (CBD) against impairments caused by cerebral ischemia. In this study, we have explored neuropharmacological mechanisms CBD action and its impact on functional recovery using a model transient global ischemia in mice. C57BL/6J mice were subjected to bilateral common carotid artery occlusion (BCCAO) for 20 min received vehicle or (10 mg/Kg) 0.5 hr before 3, 24, 48 after...
Both high fat diet (HFD) and carbohydrate (HCD) modulate brain fatty acids (FA) composition. Notwithstanding, there is a lack of information on time sequence FA deposition either for HFD or HCD. The changes in composition mice fed with HCD 7, 14, 28, 56 days were compared results 0 (before starting given the diets). mRNA expressions allograft inflammatory factor 1 (Aif1), cyclooxygenase-2 (Cox 2), F4/80, inducible nitric oxide synthase (iNOS), integrin subunit alpha m (Itgam), interleukin...
Transient, global cerebral ischemia (TGCI) causes hippocampal/cortical damage and the persistent loss of welltrained, long-term memory (retrograde amnesia). Fish oil (FO), a rich source omega-3 polyunsaturated fatty acids, abolishes such amnesia in absence neurohistological protection. The present study investigated whether FO prevents ischemia-induced oxidative stress an action contributes to lasting effect on recovery. In first experiment, was administered for 4 days prior ischemia,...
Cannabidiol (CBD), a compound obtained from Cannabis sativa, has wide range of therapeutic properties, including mitigation diabetes and neurodegeneration. Cerebral ischemia consequent learning disabilities are aggravated in elderly diabetic subjects. However, there no studies showing the effect CBD treatment patients suffering cerebral ischemia. The present work tested hypothesis that improves metabolic dysfunctions middle-aged rats submitted to chronic hypoperfusion. In this work,...
Inflammation and oxidative stress play a crucial role in the development of colorectal cancer (CRC) interference with these mechanisms represents strategy CRC chemoprevention. Allopurinol, safe molecular scavenger largely used as antigout agent, has been shown to increase survival patients advanced reduce incidence long-term gout users epidemiologic studies. We conducted randomized, double-blind, placebo-controlled preoperative trial subjects adenomatous polyps assess activity allopurinol on...
Permanent, stepwise occlusion of the vertebral arteries (VAs) and internal carotid (ICAs) following sequence VA→ICA→ICA, with an interstage interval (ISI, →) 7 days, has been investigated as a four-vessel (4-VO)/ICA model chronic cerebral hypoperfusion. This advantage not causing retinal damage. In young rats, however, 4-VO/ICA ISI days fails to cause behavioral sequelae. We hypothesized that such long would allow brain efficiently compensate for hypoperfusion, preventing occurrence...
Erysipelothrix rhusiopathiae is a Gram-positive bacillus that infrequently responsible for infections in humans. Most human cases present as localized or generalized cutaneous infections. An invasive septic form, usually associated with endocarditis, has rarely been described. We report here an infection caused by E. without endocardium involvement. To our knowledge, this the first of intra-abdominal abscess due to pathogen.
The combination of marked hypersideremia, hypertransferrinemia, and monoclonal gammopathy underdetermined significance (MGUS) should alert clinicians to the possible presence an anti-transferrin immunoglobulin, uncommon acquired disorder also defined as transferrin-immune complex disease (TICD). authors have previously described a case TICD with 100% transferrin saturation liver iron overload. However, findings in few cases so far reported are heterogeneous, high overload is not universal....
Abstract Background: Men with elevated prostate-specific antigen (PSA) and negative prostate biopsies are at risk for cancer. The antiandrogen bicalutamide has a prolonged half-life, thus potentially allowing an intermittent administration to retain activity while reducing toxicity. We conducted phase I-II trial of weekly in men PSA >4 ng/mL biopsies. Methods: Eighty subjects were nonrandomly assigned three-arm either 50 mg/wk (n = 26) or 100 28) no treatment 6 months. Blood samples...
Background : To investigate the potential use of Artificial Neural Network (ANN) in evaluation serum protein electrophoresis, we set up a multicenter study involving six Italian laboratories. For this purpose, developed an algorithm named CASPER (Computer Assisted Serum Protein Electrophoresis Recognizer). Methods A total 59,516 samples from centers were divided into three groups. Training and validation sets used to develop neural network, whereas was test performance recognizing abnormal...
We describe a patient with an unusual combination of hypersideremia (700 microg/dL), hypertransferrinemia (570 mg/dL), hyperferritinemia (800 microg/L), and monoclonal gammopathy undetermined significance (MGUS), in which the immunoglobulin showed specific transferrin-binding activity. Liver histology revealed hepatic iron overload, prominent periportal hepatocytes, suggesting intestinal hyperabsorption. demonstrate that low urinary hepcidin, likely due to impaired delivery erythroid cells...